- document
-
Barlow, S.M. (author), Boobis, A.R. (author), Bridges, J. (author), Cockburn, A. (author), Dekant, W. (author), Hepburn, P. (author), Houben, G.F. (author), König, J. (author), Nauta, M.J. (author), Schuermans, J. (author), Bánáti, D. (author)Background: Food legislation in the European Union and elsewhere includes both hazard- and risk-based approaches for ensuring safety. In hazard-based approaches, simply the presence of a potentially harmful agent at a detectable level in food is used as a basis for legislation and/or risk management action. Risk-based approaches allow...article 2015
- document
-
Koster, S. (author), Boobis, A.R. (author), Cubberley, R. (author), Hollnagel, H.M. (author), Richling, E. (author), Wildemann, T. (author), Würtzen, G. (author), Galli, C.L. (author)Unknown substances, not previously observed, are frequently detected in foods by quality control laboratories. In many cases, the assessment of these 'new' substances requires additional chemical analysis for their identification prior to assessing risk. This identification procedure can be time-consuming, expensive and in some instances...article 2011
- document
- Pelkonen, O. (author), Myllynen, P. (author), Taavitsainen, P. (author), Boobis, A.R. (author), Watts, P. (author), Lake, B.G. (author), Price, R.J. (author), Renwick, A.B. (author), Gómez-Lechón, M.J. (author), Castell, J.V. (author), Ingelman-Sundberg, M. (author), Hidestrand, M. (author), Guillouzo, A. (author), Corcos, L. (author), Goldfarb, P.S. (author), Lewis, D.F.V. (author), TNO Voeding (author) article 2001
- document
- Andersson, T.B. (author), Sjöberg, H. (author), Hoffmann, K.J. (author), Boobis, A.R. (author), Watts, P. (author), Edwards, R.J. (author), Lake, B.G. (author), Price, R.J. (author), Renwick, A.B. (author), Gómez-Lechón, M.J. (author), Castell, J.V. (author), Ingelman-Sundberg, M. (author), Hidestrand, M. (author), Goldfarb, P.S. (author), Lewis, D.F.V. (author), Corcos, L. (author), Guillouzo, A. (author), Taavitsainen, P. (author), Pelkonen, O. (author), TNO Voeding (author) article 2001
- document
-
Renwick, A.B. (author), Watts, P.S. (author), Edwards, R.J. (author), Barton, P.T. (author), Guyonnet, I. (author), Price, R.J. (author), Tredger, J.M. (author), Pelkonen, O. (author), Boobis, A.R. (author), Lake, B.G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)The maintenance of the major hepatic cytochrome P450 (CYP) enzymes has been studied in precision-cut human liver slices cultured for up to 72 h in supplemented RPMI 1640 medium. The relative apoprotein levels of 11 CYP enzymes were determined using a panel of antipeptide antibodes. In addition, 7-ethoxyresorufin O-deethylase, tolbutamide...article 2000
- document
- Renwick, A.B. (author), Watts, P.S. (author), Edwards, R.J. (author), Barton, P.T. (author), Guyonnet, I. (author), Price, R.J. (author), Tredger, J.M. (author), Pelkonen, O. (author), Boobis, A.R. (author), Lake, B.G. (author) article 2000