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Brok, H.P.M. (author), Tekoppele, J.M. (author), Hakimi, J. (author), Kerwin, J.A. (author), Nijenhuist, E.M. (author), de Groot, C.W. (author), Bontrop, R.E. (author), Hart 't, B.A. (author), Gaubius Instituut (author)CIA in the rhesus monkey is an autoimmune-based polyarthritis with inflammation and erosion of synovial joints that shares various features with human rheumatoid arthritis (RA). The close phylogenetic relationship between man and rhesus monkey makes the model very suitable for preclinical safety and efficacy testing of new therapeutics with...article 2001
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- Brok, H.P.M. (author), TeKoppele, J.M. (author), Hakimi, J. (author), Kerwin, A. (author), Nijenhuis, E.M. (author), de Groot, C.W. (author), Bontrop, R.E. (author), 't Hart, B.A. (author), Gaubius Instituut (author) article 2001
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Primatencentrum TNO (author), Slierendregt, B.L. (author), Otting, N. (author), Kenter, M. (author), Bontrop, R.E. (author)Allelic diversity at the major histocompatibility complex class II DP locus of rhesus macaques was studied by sequencing exon 2 of Mamu-DPA1 and -DPB1 genes. The Mamu-DPA1 gene is apparently invariant, whereas the Mamu-DPB1 locus displays polymorphism. Here we report the characterization of 1 Mamu-DPA1 and 13 Mamu-DPB1 alleles which were...article 1995
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Primatencentrum TNO (author), Otting, N. (author), Bontrop, R.E. (author)The evolutionary relationships among Mhc-DPA1 alleles of various nonhuman primate species was studied by sequence analysis of exon 2. Here we report the nucleotide sequences of 15 Mhc-DPA1 alleles obtained from several great ape and Old and New World monkey species. Comparison with their human homologues reveals that alleles can be grouped into...article 1995
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Heeney, J.L. (author), van Els, C. (author), de Vries, P. (author), ten Haaft, P. (author), Otting, N. (author), Koornstra, W. (author), Boes, J. (author), Dubbes, R. (author), Niphuis, H. (author), Dings, M. (author), Cranage, M. (author), Norley, S. (author), Jonker, M. (author), Bontrop, R.E. (author), Osterhaus, A. (author)To evaluate the effectiveness of vaccine protection from infected cells from another individual of the same species, vaccinated rhesus macaques (Macaca mulatta) were challenged with peripheral blood mononuclear cells from another animal diagnosed with acquired immune deficiency syndrome (AIDS). Half of the simian immunodeficiency virus (SIV)...article 1994