Searched for: author:"Bobeldijk-Pastorova, I."
(1 - 11 of 11)
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Olga, L. (author), van Diepen, J.A. (author), Bobeldijk-Pastorova, I. (author), Gross, G. (author), Prentice, S.M. (author), Snowden, S.G. (author), Furse, S. (author), Kooistra, T. (author), Hughes, I.A. (author), Schoemaker, M.H. (author), van Tol, E.A.F. (author), van Duyvenvoorde, W. (author), Wielinga, P.Y. (author), Ong, K.K. (author), Dunger, D.B. (author), Kleemann, R. (author), Koulman, A. (author)
Background: Altered lipid metabolism in early life has been associated with subsequent weight gain and predicting this could aid in obesity prevention and risk management. Here, a lipidomic approach was used to identify circulating markers for future obesity risk in translational murine models and validate in a human infant cohort. Methods:...
article 2021
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de Jong, L. (author), Bobeldijk-Pastorova, I. (author), Erdmann, J. (author), Bijker-Schreurs, M. (author), Schunkert, H. (author), Kuivenhoven, J.A. (author), van Gool, A.J. (author)
Research consortia in Europe often compete with each other for skills, human and technical resources and, eventually, recognition of the scientific impact of their work. In response to the same EU Horizon2020 call, we received funding for our research project proposals to identify and validate novel drug targets for cardiovascular disease...
article 2020
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Salic, K. (author), Gart, E. (author), Verschuren, L. (author), van Duyvenvoorde, W. (author), Wong, K.E. (author), Keijer, J. (author), Bobeldijk-Pastorova, I. (author), Wielinga, P.Y. (author), Kleemann, R. (author)
Obesity characterized by adiposity and ectopic fat accumulation is associated with the development of non-alcoholic fatty liver disease (NAFLD). Treatments that stimulate lipid utilization may prevent the development of obesity and comorbidities. This study evaluated the potential anti-obesogenic hepatoprotective effects of combined treatment...
article 2019
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van Koppen, A. (author), Verschuren, L. (author), van den Hoek, A.M. (author), Verheij, J. (author), Morrison, M.C. (author), Li, K. (author), Nagabukuro, H. (author), Costessi, A. (author), Caspers, M.P.M. (author), van den Broek, T.J. (author), Sagartz, J. (author), Kluft, C. (author), Beysen, C. (author), Emson, C. (author), van Gool, A.J. (author), Goldschmeding, R. (author), Stoop, R. (author), Bobeldijk-Pastorova, I. (author), Turner, S.M. (author), Hanauer, G. (author), Hanemaaijer, R. (author)
Background & Aims: The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events leading to hepatic fibrosis are incompletely understood. The aim of this study was to gain insight into the dynamics of key molecular processes involved in NASH and to rank early markers for...
article 2017
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Yin, X. (author), Subramanian, S. (author), Willinger, C.M. (author), Chen, G. (author), Juhasz, P. (author), Courchesne, P. (author), Chen, B.H. (author), Li, X. (author), Hwang, S.J. (author), Fox, C.S. (author), O'Donnell, C.J. (author), Muntendam, P. (author), Fuster, V. (author), Bobeldijk-Pastorova, I. (author), Sookoian, S.C. (author), Pirola, C.J. (author), Gordon, N. (author), Adourian, A. (author), Larson, M.G. (author), Levy, D. (author)
Context: Metabolic dysregulation underlies key metabolic risk factors—obesity, dyslipidemia, and dysglycemia. Objective: To uncover mechanistic links between metabolomic dysregulation and metabolic risk by testing metabolite associations with risk factors cross-sectionally and with risk factor changes over time. Design: Cross-sectional—discovery...
article 2016
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Castiglione, F. (author), Tieri, P. (author), de Graaf, A.A. (author), Franceschi, C. (author), Liò, P. (author), van Ommen, B. (author), Mazzà, C. (author), Tuchel, A. (author), Bernaschi, M. (author), Samson, C. (author), Colombo, T. (author), Castellani, G.C. (author), Capri, M. (author), Garagnani, P. (author), Salvioli, S. (author), Nguyen, V.A. (author), Bobeldijk-Pastorova, I. (author), Krishnan, S. (author), Cappozzo, A. (author), Sacchetti, M. (author), Morettini, M. (author), Ernst, M. (author)
Background: Type 2 diabetes mellitus (T2D) is a common age-related disease, and is a major health concern, particularly in developed countries where the population is aging, including Europe. The multi-scale immune system simulator for the onset of type 2 diabetes (MISSION-T2D) is a European Union-funded project that aims to develop and validate...
article 2013
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Bobeldijk-Pastorova, I. (author), Muilwijk, B. (author), Kramer, J. (author), Hekman, M. (author), Tummers, P. (author), Boon, P. (author), Lith, A. (author), van Veen, J.J.F. (author)
conference paper 2011
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Draisma, H.H.M. (author), Reijmers, T.H. (author), van Kloet, F.D. (author), Bobeldijk-Pastorova, I. (author), Spies-Faber, E. (author), Vogels, J.T.W.E. (author), Meulman, J.J. (author), Boomsma, D.I. (author), van Greef, J.D. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Combination of data sets from different objects (for example, from two groups of healthy volunteers from the same population) that were measured on a common set of variables (for example, metabolites or peptides) is desirable for statistical analysis in "omics" studies because it increases power. However, this type of combination is not directly...
article 2010
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Kleemann, R. (author), van Erk, M. (author), Verschuren, L. (author), van den Hoek, A.M. (author), Koek, M. (author), Wielinga, P.Y. (author), Jie, A. (author), Pellis, L. (author), Bobeldijk-Pastorova, I. (author), Kelder, T. (author), Toet, K. (author), Wopereis, S. (author), Cnubben, N. (author), Evelo, C. (author), van Ommen, B. (author), Kooistra, T. (author), TNO Kwaliteit van Leven (author)
BACKGROUND: The sequence of events leading to the development of insulin resistance (IR) as well as the underlying pathophysiological mechanisms are incompletely understood. As reductionist approaches have been largely unsuccessful in providing an understanding of the pathogenesis of IR, there is a need for an integrative, time-resolved approach...
article 2010
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Draisma, H.H.M. (author), Reijmers, T.H. (author), Bobeldijk - Pastorova, I. (author), Meulman, J.J. (author), van Estourgie - Burk, G.F. (author), Bartels, M. (author), Ramaker, R. (author), van der Greef, J. (author), Boomsma, D.I. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Differences in genetic background and/or environmental exposure among individuals are expected to give rise to differences in measurable characteristics, or phenotypes. Consequently, genetic resemblance and similarities in environment should manifest as similarities in phenotypes. The metabolome reflects many of the system properties, and is...
article 2008
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Stolker, A.A.M. (author), van Schoonhoven, J. (author), de Vries, A.J. (author), Bobeldijk-Pastorova, I. (author), Vaes, W.H.J. (author), van den Berg, R. (author), TNO Voeding (author)
article 2004
Searched for: author:"Bobeldijk-Pastorova, I."
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