Economic Evaluation of Different Screening Strategies for Severe Combined Immunodeficiency Based on Real-Life Data

Although several countries have adopted severe combined immunodeficiency (SCID) into their newborn screening (NBS) program, other countries are still in the decision process of adding this disorder in their program and finding the appropriate screening strategy. This decision may be influenced by the cost(-effectiveness) of these screening...

Expanding Neonatal Bloodspot Screening: A Multi-Stakeholder Perspective

Neonatal bloodspot screening (NBS) aims to detect treatable disorders in newborns. The number of conditions included in the screening is expanding through technological and therapeutic developments, which can result in health gain for more newborns. NBS expansion, however, also poses healthcare, ethical and societal challenges. This qualitative...

Exploring Evaluation Variables for Low-Cost Particulate Matter Monitors to Assess Occupational Exposure

Background: Small, lightweight, low-cost optical particulate matter (PM) monitors are becoming popular in the field of occupational exposure monitoring, because these devices allow for real-time static measurements to be collected at multiple locations throughout a work site as well as being used as wearables providing personal exposure...

Houtrook uit particuliere kachels: zoektocht naar indicatoren en verkenning van mogelijkheden voor reductie van overlast

Cost-effectiveness of newborn screening for severe combined immunodeficiency

Severe combined immunodeficiency (SCID) is a condition that often results in severe infections and death at young age. Early detection shortly after birth, followed by treatment before infections occur, largely increases the chances of survival. As the incidence of SCID is low, assessing cost-effectiveness of adding screening for SCID to the...

Defining the targets for the assessment of IgE-mediated allergenicity of new or modified food proteins

Many food innovations rely on the introduction and use of new or modified proteins. New or modified food proteins may lead to major health risks due to their inherent potential to cause food allergy. Currently, the pre-market allergenicity assessment for new or modified food proteins and protein sources relies on methods for identifying...

Introducing Newborn Screening for Severe Combined Immunodeficiency (SCID) in the Dutch Neonatal Screening Program

The implementation of newborn screening for severe combined immunodeficiency (SCID) in the Netherlands is a multifaceted process in which several parties are involved. The Dutch Ministry of Health adopted the advice of the Dutch Health Council to include SCID in the Dutch newborn screening program in 2015. As newborn screening for SCID is...

Aerosol source apportionment from 1-year measurements at the CESAR tower in Cabauw, the Netherlands

Intensive measurements of submicron aerosol particles and their chemical composition were performed with an Aerosol Chemical Speciation Monitor (ACSM) at the Cabauw Experimental Site for Atmospheric Research (CESAR) in Cabauw, the Netherlands, sampling at 5m height above ground. The campaign lasted nearly 1 year from July 2012 to June 2013 as...

Microfluidic standardization: Past, present and future

This paper addresses the issue of standardization in microfluidics. It contains the main points of an industry wide agreement about microfluidic port pitches and port nomenclature. It also addresses device classification and future steps.

Towards a food-allergy-free world

Food allergy is one of the most common health disorders in the western world. It affects about three per cent of the total population. Food allergy is potentially lethal, and its health impact is higher than that posed by all known chemicals and microbes in food. It is also higher than that of many other disorders and diseases. Additionally,...

Allergenen managen: Risico's beter schatten en duidelijk communíceren

Dankzij verzamelde patiëntgegevens en kwantitatieve richtlijnen voor de belangrijke allergenen gaat het risicomanagement van allergenen veranderen, De producent kan risico's van kruiscontaminatie beter schatten in relatie tot de beheersing van allergenen in de productie, Door daarover duidelijk te communiceren, kan de consument deze risico's...

New Developments in Food Safety Assessment: Innovations in Food Allergy and Toxicological Safety Assessment

Beter geïnformeerd op weg: Routekaart 2013 - 2023 : Hoofddocument

On 4 November governments, market players, stakeholders, knowledge institutions and research organisations presented a joint strategy to use innovative technology to tackle traffic jams. The ‘Better informed on route’ navigation map sets out the investment course for the parties involved, including TNO, in large-scale implementation of...

Functional requirements for assistive technology for people with cognitive impairments and dementia

The amount of technological aids on the market to support people in their everyday functioning is increasing. For example mobile telephone, electronic diary, skyping and domotics. Many of these aids are too complicated to operate for people with cognitive impairments, like dementia. For technology to be practicable and useful for them, it will...