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CIVO-Toxicologie en Voeding TNO (author), Willems, M.I. (author), Blijleven, W.G.H. (author), Splinter, A. (author), Roelfzema, H. (author), Feron, V.J. (author)A system for classifying genotoxic carcinogens according to their estimated risk for humans in the occupational situation has been worked out. Three classes were defined qualifying carcinogens of low, intermediate and high potency, respectively. The developed system is based on the TD 50 - value combined with weighing factors, finally resulting...report 1990
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Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author), Blijleven, W.G.H. (author), Dreef-van der Meulen, H.C. (author), Kodter, H.B.W.M. (author), Strijkel, A. (author), Zielhuis, R.L. (author)Literatuuronderzoek is verricht naar mogelijke schadelijke invloeden op de voortplanting door chemische stoffen die in de arbeidssituatie gebruikt worden. Hierbij werd aandacht geschonken aan zowel de gevoeligheid van het mannelijk reproductiesysteem, als het vrouwelijk reproductiesysteem en de conceptus. Besproken worden de belangrijke...book 1989
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Instituut CIVO-Toxicologie en Voeding TNO (author), Koëter, H.B.W.M. (author), Blijleven, W.G.H. (author), Dreef-van der Meulen, H.C. (author), Stijkel, A. (author), Zielhuis, R.L. (author)According to a study in animals described by Schwetz et al. (1974), pentachlorophenol induces embryotoxic and teratogenic effects whereas Welsh et al. (1987) reported embryolethal effects. Further any animal and human data with respect to endocrine system, gonads and fertility are lacking. Data on offspring are inadequate for evaluation. It is...book 1989
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Instituut CIVO-Toxicologie en Voeding TNO (author), Koëter, H.B.W.M. (author), Blijleven, W.G.H. (author), Dreef-van der Meulen, H.C. (author), Stijkel, A. (author), Zielhuis, R.L. (author)From this literature survey it appeared that there is a considerable lack of information with respect to organic solvents both of human and laboratory animal fertility and reproduction: only xylene is reasonable studied in animals. Since human exposures to a number of organic solvents is widespread and there are at least indications from both...book 1989
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Instituut CIVO-Toxicologie en Voeding TNO (author), Koëter, H.B.W.M. (author), Blijleven, W.G.H. (author), Dreef-van der Meulen, H.C. (author), Stijkel, A. (author), Zielhuis, R.L. (author)Both available animal and human data are inadequate for the evaluation of risks with respect to the endocrine system, the reproductive organs and fertility. Limited studies in animals have shown that vinylchloride is not teratogenic or embryotoxic at otherwise non-toxic doses. There are insufficient data with respect to the assessment of a NEAL....book 1989
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Instituut CIVO-Toxicologie en Voeding TNO (author), Koëter, H.B.W.M. (author), Blijleven, W.G.H. (author), Dreef-van der Meulen, H.C. (author), Wibowo, A.E. (author), Zielhuis, R.L. (author)On the basis of both animal and human data the effects of inorganic lead to reproduction are evaluated, and the risks of exposure to lead are assessed.book 1989
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Instituut CIVO-Toxicologie en Voeding TNO (author), Koëter, H.B.W.M. (author), Blijleven, W.G.H. (author), Dreef-van der Meulen, H.C. (author), Stijkel, A. (author), Zielhuis, R.L. (author)It is concludes on the basis of animal studies that formamide is highly embryolethal and teratogenic. N,N-dimethylformamide is probably embryolethal but not teratogenic. Although at least in one study (Keller and Lewis, 1981) it was concluded that the current MAC of 10 ppm gives adequate protection, effects on reproductive parameters have also...book 1989
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Instituut CIVO-Toxicologie en Voeding TNO (author), Koëter, H.B.W.M. (author), Blijleven, W.G.H. (author), Dreef-van der Meulen, H.C. (author), Stijkel, A. (author), Zielhuis, R.L. (author)In two rat studies the NAEL was established at 1000 mg/kg/day, and in a mouse study on 750 mg/kg/day. Sufficient data is lacking to draw a well documented conclusion about the risks of exposure of female animals with respect to the gonads, endocrine system and fertility. Concerning the risks of female animals with respect to gestation and...book 1989