Lysine-based cluster mannosides that inhibit ligand binding to the human mannose receptor at nanomolar concentration

In search of synthetic high affinity ligands for the mannose receptor, we synthesized a series of lysine-based oligomannosides containing two (M2L) to six (M6L5) terminal alpha-D-mannose groups that are connected with the backbone by flexible elongated spacers (16 Å). The synthesized cluster mannosides were all able to displace binding of...

Prolonged circulation of tissue-type plasminogen activator in vivo by blocking mannose receptor and low-density-lipoprotein receptor-related protein-mediated liver uptake;

Abstract

A monogalactosylated cholesterol derivative that specifically induces uptake of LDL by the liver