Searched for: author%3A%22Berends%2C+F.%22
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Mientjes, E.J. (author), Luiten-Schuite, A. (author), van der Wolf, E. (author), Borsboom, Y. (author), Bergmans, A. (author), Berends, F. (author), Lohman, P.H.M. (author), Baan, R.A. (author), van Delft, J.H.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
To investigate tissue-specific relations between DNA adducts and mutagenesis in vivo, λlacZ transgenic mice were treated i.p. with N-ethyl-N-nitrosourea (ENU), diethylnitrosamine (DEN), and ethyl methanesulphonate (EMS). In liver, bone marrow, and brain DNA from mice sacrificed at several time points after treatment O6-ethylguanine (O6-EtG) and...
article 1998
document
Blommaert, F.A. (author), Floot, B.G.J. (author), van Dijk-Knijnenburg, H.C.M. (author), Berends, F. (author), Baan, R.A. (author), Schornagel, J.H. (author), den Engelse, L. (author), Fichtinger-Schepman, A.M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
We have studied the formation and repair of cisplatin-DNA adducts in wild-type mouse leukemia L1210/0 cells and in the sublines L1210/2 and L1210/5, which differ in cisplatin sensitivity. In a colony-formation assay these sublines were 9- and 22-fold more resistant compared to L1210/0, respectively. Cisplatin-induced DNA modification was studied...
article 1998
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Mientjes, E.J. (author), Hochleitner, K. (author), Luiten-Schuite, A. (author), van Delft, J.H.M. (author), Thomale, J. (author), Berends, F. (author), Rajewsky, M.F. (author), Lohman, P.H.M. (author), Baan, R.A. (author), TNO Voeding (author)
LacZ transgenic mice are suitable for short-term mutagenicity studies in vivo. Mutagenicity in these mice is determined in the lacZ transgene. Since the lacZ gene is of bacterial origin the question has been raised whether DNA-adduct formation and repair in the transgene are comparable to those in total genomic DNA. Mice were treated with N...
article 1996
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Fichtinger-Schepman, A.M.J. (author), Welters, M.J.P. (author), van Dijk-Knijnenburg, H.C.M. (author), van der Sterre, M.L.T. (author), Tilby, M.J. (author), Berends, F. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In order to determine the nature of the cytotoxic lesion(s) formed by the antitumour drugs cisplatin and carboplatin, a comparative study was made of bifunctional DNA-adduct formation by these drugs. The kinetics of bifunctional cisplatin adduct formation were studied with DNA in vitro and in cultured Chinese hamster ovary (CHO) cells. Prior to...
bookPart 1996
document
Fichtinger-Schepman, A.M.J. (author), van Dijk-Knijnenburg, H.C.M. (author), van der Velde-Visser, S.D. (author), Berends, F. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1995
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Blommaert, F.A. (author), van Dijk-Knijnenburg, H.C.M. (author), Dijt, F.J. (author), den Engelse, L. (author), Baan, R.A. (author), Berends, F. (author), Fichtinger-Schepman, A.M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1995
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Fichtinger-Schepman, A.M.J. (author), van Dijk-Knijnenburg, H.C.M. (author), Dijt, F.J. (author), van der Velde-Visser, S.D. (author), Berends, F. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Cisplatin reacts with DNA by forming mainly bifunctional adducts via reactive monofunctional intermediates. When freshly platinated DNA was postincubated with thiourea (10 mM, at 23 or 37°C) for periods of up to 24 h, followed by determination of mono- and diadducts, a rapid initial decrease was seen in the fraction of diadducts, followed by a...
article 1995
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Fichtinger-Schepman, A.M.J. (author), Velde van der - Visser, S.D. (author), Dijk van - Knijnenburg, H.C.M. (author), van Oosterom, A.T. (author), Baan, R.A. (author), Berends, F. (author), TNO Voeding Medisch biologisch laboratorium TNO (author)
During chemotherapy with a cisplatin-containing combination of drugs, 217 blood samples from 30 cancer patients were analyzed for the presence of the main cisplatin-DNA adduct cis-Pt(NH3)2d(pGpG) (Pt-GG). Cisplatin was administered during 3-h infusions on each of 5 consecutive days, resulting in increasing adduct levels which, on the average,...
article 1990
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Medisch Biologisch Laboratorium TNO (author), Mullaart, E. (author), Lohman, P.H.M. (author), Berends, F. (author), Vijg, J. (author)
As a result of permanent exposure to low levels of various endogenous and exogenous genotoxic agents, large numbers of lesions are continuously induced in the DNA of cells of living organisms. Such lesions could lead to dysfunction of cells and tissues, and they might well be the underlying cause of the age-related reduction of homeostatic...
article 1990
document
Lohman, P.H.M. (author), Berends, F. (author), Medisch Biologisch Laboratorium TNO (author)
bookPart 1986
document
Medisch Biologisch Laboratorium TNO (author), Jansen, J.D. (author), Lohman, P.H.M. (author), Berends, F. (author)
article 1986
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Medisch Biologisch Laboratorium TNO (author), Jansen, J.D. (author), Lohman, P.H.M. (author), Berends, F. (author)
Deze literatuurstudie biedt een overzicht van methoden, die nu reeds voorhanden of in ontwikkeling zijn, om blootstelling aan DNA beschadigende stoffen bij werknemers op te kunnen sporen. De blootstelling aan mutagene of carcinogene stoffen wordt d.m.v. biological monitoring nagegaan. Development of methods for estimating exposure to mutagenic...
book 1985
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Abbondandolo, A. (author), Dogliotti, E. (author), Lohman, P.H.M. (author), Berends, F. (author), Medisch Biologisch Laboratorium TNO (author)
Cultured Chinese hamster ovary cells were treated with ethylating agents. DNA lesions giving rise to single-strand breaks (ssb) or alkali-labile sites were measured by centrifugation in alkaline sucrose gradients after lysis in alkali. 4 agents with different tendencies to ethylate preferentially either at N or O atoms were compared, namely N...
article 1982
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Wade, D.R. (author), Lohman, P.H.M. (author), Mattern, I.E. (author), Berends, F. (author), Medisch Biologisch Laboratorium TNO (author)
A commercial sample of the tuberculostatic drug isoniazid (INH) was found to have a weak mutagenic activity towards Salmonella typhimurium strains TA100 and TA1535. The addition of a rat or mouse liver homogenate to the test system decreased the mutagenic effect of INH. Hydrazine, an impurity of the INH sample, was also weakly mutagenic in...
article 1981
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Benschop, H.P. (author), Berends, F. (author), de Jong, L.P.A. (author), Medisch Biologisch Laboratorium TNO (author)
Chemicals/CAS: soman, 96-64-0; Organophosphorus Compounds; Soman, 96-64-0
article 1981
document
Wolthuis, O.L. (author), Benschop, H.P. (author), Berends, F. (author), Medisch Biologisch Laboratorium TNO (author)
Anaesthetized, atropinized rats were posioned with 6x LD50 soman (1,2,2-trimethylpropyl methylphosphonofluoridate). Purified acetylcholinesterase, injected i.v. 75 min later, was rapidly inhibited, presumably by soman stored in a 'depot' from which it was gradually released. Existence of a depot is supported by the effect of a soman-simulator (...
article 1981
document
Zelle, B. (author), Berends, F. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)
The xeroderma pignemtosum fibroblast strains XP2RO, complementation group E, and XP23OS, group F were compared with normal human primary fibroblasts UV. regard to repair of damage induced by 254-nn UV> In XP2RO cells, repair DNA synthesis, measured by autoradiography (unscheduled DNA synthesis = UDS), was about 50% of the value found in normal...
article 1980
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Benschop, H.P. (author), van den Berg, G.R. (author), van Hooidonk, C. (author), de Jong, L.P.A. (author), Kientz, C.E. (author), Berends, F. (author), Kepner, L.A. (author), Meeter, E. (author), Visser, R.P.L.S. (author), Medisch Biologisch Laboratorium TNO (author)
Three new nonquaternary oximes have been evaluated with respect to their antidotal activities against organophosphate poisoning. The oximes 1,2,3-thiadiazole-5-carboxaldoxime (1, pKa = 7.6), 2-methyl-1,3,4-thiadiazole-5-carboxaldoxime (2, pKa = 8.4), and 3-methyl-1,2,4-thiadiazole-5-carboxaldoxime (3, pKa = 7.0) were prepared in yields of 56, 24...
article 1979
document
Cohen, J.A. (author), Oosterbaan, R.A. (author), Berends, F. (author), Medisch Biologisch Laboratorium TNO (author)
bookPart 1967
document
Berends, F. (author), Rorsch, A. (author), Stevens, W.F. (author), Medisch Biologisch Laboratorium TNO (author)
conference paper 1966
Searched for: author%3A%22Berends%2C+F.%22
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