Searched for: author%3A%22Beijnen%2C+J.H.%22
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Vlaming, M.L.H. (author), Teunissen, S.F. (author), van de Steeg, E. (author), van Esch, A. (author), Wagenaar, E. (author), Brunsveld, L. (author), de Greef, T.F.A. (author), Rosing, H. (author), Schellens, J.H.M. (author), Beijnen, J.H. (author), Schinkel, A.H. (author)
The multidrug transporters breast cancer resistance protein (BCRP), multidrug-resistance protein 1 (MDR1), and multidrugresistance‚Äďassociated protein (MRP) 2 and 3 eliminate toxic compounds from tissues and the body and affect the pharmacokinetics of many drugs and other potentially toxic compounds. The food-derived carcinogen PhIP (2-amino-1...
article 2014
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Jacobs, P.L. (author), Ridder, L. (author), Ruijken, M. (author), Rosing, H. (author), Jager, N.G.L. (author), Beijnen, J.H. (author), Bas, R.R. (author), van Dongen, W.D. (author), TNO Triskelion BV (author)
Background: Comprehensive identification of human drug metabolites in first-in-man studies is crucial to avoid delays in later stages of drug development. We developed an efficient workflow for systematic identification of human metabolites in plasma or serum that combines metabolite prediction, high-resolution accurate mass LC-MS and MS vendor...
article 2013