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Reproducibility of food challenge to cow's milk: Systematic review with individual participant data meta-analysis

Turner, P.J. (author), Patel, N. (author), Campbell, D.E. (author), Sampson, H.A. (author), Maeda, M. (author), Katsunuma, T. (author), Westerhout, J. (author), Blom, W.M. (author), Baumert, J.L. (author), Houben, G.F. (author), Remington, B.C. (author)

Background: Cow's milk (CM) is an increasingly common cause of severe allergic reactions, but there is uncertainty with respect to severity of reactions at low-level CM exposure, as well as the reproducibility of reaction thresholds. Objective: We undertook an individual participant data (IPD) meta-analysis of studies reporting double-blind,...

article 2022

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Updated full range of Eliciting Dose values for Cow's milk for use in food allergen risk assessment

Blom, W.M. (author), Westerhout, J. (author), Baumert, J.L. (author), Meima, M.Y. (author), Turner, P.J. (author), Ebisawa, M. (author), Yanagida, N. (author), Remington, B.C. (author), Houben, G.F. (author)

Access to Eliciting Doses (ED) for allergens enables advanced food allergen risk assessment. Previously, the full ED range for 14 allergenic foods, including milk, and recommendations for their use were provided (Houben et al., 2020). Additional food challenge studies with cow's milk-allergic patients added 247 data points to the original...

article 2022

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Too high, too low: The complexities of using thresholds in isolation to inform precautionary allergen ('may contain') labels: editorial

Turner, P.J. (author), Baumert, J.L. (author), Beyer, K. (author), Brooke-Taylor, S. (author), Comberiati, P. (author), Crevel, R.W.R. (author), Gerdts, J.D. (author), Hazel G.M., (author), Houben, G.F. (author), Hourihane, J.O'B (author), Konstantinou, G.N. (author), La Vieille, S. (author), Moya, B. (author), Muraro, A. (author), Mills, E.N.C. (author), Patel, N. (author), Podestà, M. (author), Popping, B. (author), Reese, I. (author), Roberts, G. (author), Said, M. (author), Santos, A.F. (author), Schnadt, S. (author), Taylor, S.L. (author), Vlieg-Boerstra, B. (author), Remington, B.C. (author)

article 2022

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Peanut Can Be Used as a Reference Allergen for Hazard Characterization in Food Allergen Risk Management: A Rapid Evidence Assessment and Meta-Analysis

Turner, P.J. (author), Patel, N. (author), Ballmer-Weber, B.K. (author), Baumert, J.L. (author), Blom, W.M. (author), Brooke-Taylor, S. (author), Brough, H. (author), Campbell, D.E. (author), Chen, H. (author), Chinthrajah, R.S. (author), Crevel, R.W.R. (author), Dubois, A.E.J. (author), Ebisawa, M. (author), Elizur, A. (author), Gerdts, J.D. (author), Gowland, M.H. (author), Houben, G.F. (author), Hourihane, J.O.B. (author), Knulst, A.C. (author), La Vieille, S. (author), López, M.C. (author), Mills, E.N.C. (author), Polenta, G.A. (author), Purington, N. (author), Said, M. (author), Sampson, H.A. (author), Schnadt, S. (author), Södergren E., (author), Taylor, S.L. (author), Remington, B.C. (author)

Regional and national legislation mandates the disclosure of “priority” allergens when present as an ingredient in foods, but this does not extend to the unintended presence of allergens due to shared production facilities. This has resulted in a proliferation of precautionary allergen (“may contain”) labels (PAL) that are frequently ignored by...

article 2022

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Methods to determine the risk of unintended allergen presence related to the dispersion of allergenic food particles in food production areas

Meima, M.Y. (author), Remington, B.C. (author), Blom, W.M. (author), Baumert, J.L. (author), Taylor, S.L. (author), Jeffery, B. (author), Robert, M.C. (author), Houben, G.F. (author), Lucas Luijckx, N.B. (author)

Allergenic food particles (typically ~0.5–5 mm) may unintentionally end up in food products during production and can pose a risk for the allergic consumer. A single particle can provoke allergic symptoms in an allergic consumer when the dose of allergenic protein exceeds minimal eliciting doses. However, there is a lack of fundamental knowledge...

article 2021

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Suitability of low-dose open food challenge data to supplement double-blind placebo-controlled data in generation of food allergen threshold dose distributions

Remington, B.C. (author), Westerhout, J. (author), Dubois, A.E.J. (author), Blom, W.M. (author), Kruizinga, A.G. (author), Taylor, S.L. (author), Houben, G.F. (author), Baumert, J.L. (author)

Food allergen threshold dose distributions are used in food allergen risk assessment to determine the level of risk within a food-allergic population to a defined exposure amount of allergenic food protein and to help inform allergen risk management decisions. There has been a long-standing interest in determining threshold dose distributions...

article 2021

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The population threshold for soy as an allergenic food – Why did the Reference Dose decrease in VITAL 3.0?

Taylor, S.L. (author), Houben, G.F. (author), Blom, W.M. (author), Westerhout, J. (author), Remington, B.C. (author), Crevel, R.W.R. (author), Brooke-Taylor, S. (author), Baumert, J.L. (author)

Background. Soy is globally recognized as a commonly allergenic food. The VITAL (Voluntary Incidental Trace Allergen Labeling) Scientific Expert Panel (VSEP) of the Allergen Bureau of Australia & New Zealand used data on minimal reactive doses in low-dose clinical challenges of soy-allergic individuals to elaborate and propose the first...

article 2021

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Using data from food challenges to inform management of consumers with food allergy: A systematic review with individual participant data meta-analysis

Patel, N. (author), Adelman, D.C. (author), Anagnostou, K. (author), Baumert, J.L. (author), Blom, W.M. (author), Campbell, D.E. (author), Chinthrajah, R.S. (author), Mills, E.N.C. (author), Javed, B. (author), Purington, N. (author), Remington, B.C. (author), Sampson, H.A. (author), Smith, A.D. (author), Yarham, R.A.R. (author), Turner, P.J. (author)

Background Eliciting doses (EDs) (eg, ED01 or ED05 values, which are the amounts of allergen expected to cause objective symptoms in 1% and 5% of the population with an allergy, respectively) are increasingly being used to inform allergen labeling and clinical management. These values are generated from food challenge, but the frequency of...

article 2021

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Updated population minimal eliciting dose distributions for use in risk assessment of 14 priority food allergens

Remington, B.C. (author), Westerhout, J. (author), Meima, M.Y. (author), Blom, W.M. (author), Kruizinga, A.G. (author), Wheeler, M.W. (author), Taylor, S.L. (author), Houben, G.F. (author), Baumert, J.L. (author)

Food allergy and allergen management are important global public health issues. In 2011, the first iteration of our allergen threshold database (ATDB) was established based on individual NOAELs and LOAELs from oral food challenge in roughly 1750 allergic individuals. Population minimal eliciting dose (EDp) distributions based on this dataset...

article 2020

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Effect of heat treatment on the conformational stability of intact and cleaved forms of the peanut allergen Ara h 6 in relation to its IgE-binding potency

de Jongh, H.H.J. (author), de Jong, G.A.H. (author), Apostolovic, D. (author), Taylor, S.L. (author), Baumert, J.L. (author), Koppelman, S.J. (author)

This work reports on the effect of heat treatment on the protein conformational stability of intact and post-translationally cleaved peanut allergen Ara h 6 in relation to IgE-binding. Intact and post-translationally cleaved Ara h 6 are structurally similar and their strong resistance to denaturant-induced unfolding is comparable. Only upon...

article 2020

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Full range of population Eliciting Dose values for 14 priority allergenic foods and recommendations for use in risk characterization

Houben, G.F. (author), Baumert, J.L. (author), Blom, W.M. (author), Kruizinga, A.G. (author), Meima, M.Y. (author), Remington, B.C. (author), Wheeler, M.W. (author), Westerhout, J. (author), Taylor, S.L. (author)

Previously, we published selected Eliciting Dose (ED) values (i.e. ED01 and ED05 values) for 14 allergenic foods, predicted to elicit objective allergic symptoms in 1% and 5%, respectively, of the allergic population (Remington et al., 2020). These ED01 and ED05 values were specifically presented and discussed in the context of establishing...

article 2020

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Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens

Westerhout, J. (author), Baumert, J.L. (author), Blom, W.M. (author), Allen, K.J. (author), Ballmer-Weber, B. (author), Crevel, R.W.R. (author), Dubois, A.E.J. (author), Fernández-Rivas, M. (author), Greenhawt, M.J. (author), Hourihane, J.O. (author), Koplin, J.J. (author), Kruizinga, A.G. (author), Le, T.M. (author), Sampson, H.A. (author), Shreffler, W.G. (author), Turner, P.J. (author), Taylor, S.L. (author), Houben, G.F. (author), Remington, B.C. (author)

Background: Food allergies are a significant public health issue, and the only effective management option currently available is strict avoidance of all foods containing the allergen. In view of the practical impossibility of limiting risks to zero, quantitative allergen risk assessment and management strategies are needed. Objective: We sought...

article 2019

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Sensitivity analysis to derive a food consumption point estimate for deterministic food allergy risk assessment

Blom, W.M. (author), Remington, B.C. (author), Baumert, J.L. (author), Bucchini, L. (author), Crépet, A. (author), Crevel, R.W.R. (author), Madsen, C.B. (author), Taylor, S.L. (author), Houben, G.F. (author), Kruizinga, A.G. (author)

One of the input parameters in food allergy risk assessment is the amount of a given food consumed at an eating occasion. There is no consensus on how to use food consumption data when assessing the risk from unintended allergen presence in food products. A sensitivity analysis was performed to establish the optimal food consumption estimate for...

article 2019

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Frequentist and Bayesian approaches for food allergen risk assessment: risk outcome and uncertainty comparisons

Birot, S. (author), Crépet, A. (author), Remington, B.C. (author), Madsen, C.B. (author), Kruizinga, A.G. (author), Baumert, J.L. (author), Brockhoff, P.B. (author)

Peer-reviewed probabilistic methods already predict the probability of an allergic reaction resulting from an accidental exposure to food allergens, however, the methods calculate it in different ways. The available methods utilize the same three major input parameters in the risk model: the risk is estimated from the amount of food consumed,...

article 2019

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The importance of reducing risk in peanut allergy: Current and future therapies

Shreffler, W.G. (author), Baumert, J.L. (author), Remington, B.C. (author), Koppelman, S.J. (author), Dinakar, C. (author), Fleischer, D.M. (author), Kim, E. (author), Tilles, S.A. (author), Spergel, J.M. (author)

article 2018

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Detection of peanut allergen in human blood after consumption of peanuts is skewed by endogenous immunoglobulins

Janssen-Duijghuijsen, L.M. (author), Wichers, H.J. (author), van Norren, K. (author), Keijer, J. (author), Baumert, J.L. (author), de Jong, G.A.H. (author), Witkamp, R.F. (author), Koppelman, S.J. (author)

Some studies have suggested that allergens may appear in the circulation after ingestion of allergenic food sources. The reported levels of allergen in serum, however, are low, and conclusions between studies differ. Here, we investigated factors that determine the detection of allergens in serum after consumption of peanuts. Ten healthy...

article 2017

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Specific IgE to Jug r 1 has no additional value compared with extract-based testing in diagnosing walnut allergy in adults

TNO Kwaliteit van Leven (author), Blankestijn, M.A. (author), Blom, W.M. (author), Otten, H.G. (author), Baumert, J.L. (author), Taylor, S.L. (author), Bruijnzeel-Koomen, C.A.F.M. (author), Houben, G.F. (author), Knulst, A.C. (author), Klemans, R.J.B. (author)

Chemicals / CAS immunoglobulin E, 37341-29-0; Allergens; Immunoglobulin E; Plant Extracts; Plant Proteins

article 2017

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Threshold Dose Distribution in Walnut Allergy

TNO Kwaliteit van Leven (author), Blankestijn, M.A. (author), Remington, B.C. (author), Houben, G.F. (author), Baumert, J.L. (author), Knulst, A.C. (author), Blom, W.M. (author), Klemans, R.J.B. (author), Taylor, S.L. (author)

Background In food allergy, eliciting doses (EDs) of foods on a population level can improve risk management and labeling strategies for the food industry and regulatory authorities. Previously, data available for walnut were unsuitable to determine EDs. Objective The objective of this study was to determine EDs for walnut allergic adults and to...

article 2017

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Conformational stability of digestion-resistant peptides of peanut conglutins reveals the molecular basis of their allergenicity

Danijela Apostolovic, D. (author), Dragana Stanic-Vucinic, D. (author), de Jongh, H.H.J. (author), de Jong, G.A.H. (author), Mihailovic, J. (author), Radosavljevic, J. (author), Radibratovic, M. (author), Nordlee, J.A. (author), Baumert, J.L. (author), Milcic, M. (author), Taylor, S.L. (author), Garrido Clua, N. (author), Cirkovic Velickovic, T. (author), Koppelman, S.J. (author)

Conglutins represent the major peanut allergens and are renowned for their resistance to gastro-intestinal digestion. Our aim was to characterize the digestion-resistant peptides (DRPs) of conglutins by biochemical and biophysical methods followed by a molecular dynamics simulation in order to better understand the molecular basis of food...

article 2016

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Sesame allergy threshold dose distribution

Dano, D. (author), Remington, B.C. (author), Astier, C. (author), Baumert, J.L. (author), Kruizinga, A.G. (author), Bihain, B.E. (author), Taylor, S.L. (author), Kanny, G. (author)

Background: Sesame is a relevant food allergen in France. Compared to other allergens there is a lack of food challenge data and more data could help sesame allergy risk management. The aim of this study is to collect more sesame challenge data and investigate the most efficient food challenge method for future studies. Method: Records of...

article 2015