InTESTine™ Intestinal absorption, metabolism and inflammatory responses: human intestinal absorption and metabolism

The TNO InTESTine™ system is developed to study the absorption and translocation of pharmaceutical, biological and nutritional compounds across the intestinal wall in a physiologically relevant model. In this medium-throughput system, fresh ex vivo intestinal tissue from human or animal origin is mounted into a two compartment model with an...

Drug transporters: kinetics and metabolism

Transporter proteins are embedded in plasma membranes and actively transport their substrates (drugs, food components or endogenous compounds) into or out of the cell. Transporters play a significant role in the absorption, distribution and excretion of drugs. Drug-transporter interactions can cause unwanted drug-drug or drug-food interactions...

Accelerate your clinical development: accelerator mass spectometer

The development of new medicines is a costly and time consuming process. One way to increase the effi ciency of drug development pipelines is by using microtracer dosing. Microtracing is an innovative technology in which very small quantities of substances are tested in humans at a very early stage of development. No more than 100 micrograms, or...

Quantitative protein abundance measurements: absolute quantification of plasma membrane measurements

Membrane embedded transporter proteins play an important role in the absorption, distribution and excretion of many drugs. A reliable prediction of human pharmacokinetics of (new) drugs based on PBPK modeling is highly dependent on accurate determination of the absolute protein expression levels of these transmembrane transporter proteins.