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Comparative methodologies for measuring metabolizable energy of various types of resistant high amylose corn starch

Tulley, R.T. (author), Appel, M.J. (author), Enos, T.G. (author), Hegsted, M. (author), Mccutcheon, K.L. (author), Zhou, J. (author), Raggio, A.M. (author), Jeffcoat, R. (author), Birkett, A. (author), Martin, R.J. (author), Keenan, M.J. (author), TNO Kwaliteit van Leven (author)

Energy values of high amylose corn starches high in resistant starch (RS) were determined in vivo by two different methodologies. In one study, energy values were determined according to growth relative to glucose-based diets in rats fed diets containing RS2, heat-treated RS2 (RS2-HT), RS3, and amylase predigested versions to isolate the RS...

article 2009

document

Within-animal variation as a minimal critical effect size for continuous toxicological parameters applicable in the Benchmark dose approach (Extended Abstract)

Dekkers, S. (author), Telman, J. (author), Rennen, M.A.J. (author), Appel, M.J. (author), Buist, H.E. (author), de Heer, C. (author)

article 2006

document

Within-animal variation as an indication of the minimal magnitude of the critical effect size for continuous toxicological parameters applicable in the benchmark dose approach

Dekkers, S. (author), Telman, J. (author), Rennen, M.A.J. (author), Appel, M.J. (author), de Heer, C. (author), TNO Industrie en Techniek TNO Kwaliteit van Leven (author)

In this study, the within-animal variation in routinely studied continuous toxicological parameters was estimated from temporal fluctuations in individual healthy nonexposed animals. Assuming that these fluctuations are nonadverse, this within-animal variation may be indicative of the minimal magnitude of the critical effect size (CES). The CES...

article 2006

document

Sub-chronic (13-week) oral toxicity study in rats with recombinant human lactoferrin produced in the milk of transgenic cows

Appel, M.J. (author), van Veen, H.A. (author), Vietsch, H. (author), Salaheddine, M. (author), Nuijens, J.H. (author), Ziere, B. (author), de Loos, F. (author), TNO Kwaliteit van Leven (author)

The oral toxicity of recombinant human lactoferrin (rhLF) produced in the milk of transgenic cows was investigated in Wistar rats by daily administration via oral gavage for 13 consecutive weeks, 7 days per week. The study used four groups of 20 rats/sex/dose. The control group received physiological saline and the three test groups received...

article 2006

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Effects of a diet high in fish oil (MaxEPA) on the formation of micronucleated erythrocytes in blood and on the number of atypical acinar cell foci induced in rat pancreas by Azaserine

Appel, M.J. (author), Woutersen, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

The present study was performed to investigate the influence of fish oil on the genotoxic effects of azaserine, using the formation of micronucleated erythrocytes as a measure for the degree of initiating potency and the number and size of putative preneoplastic pancreatic atypical acinar cell foci (AACF) as a measure for the actual number of...

article 2004

document

Subacute (28-day) toxicity of furfural in Fischer 344 rats: A comparison of the oral and inhalation route

Arts, J.H.E. (author), Muijser, H. (author), Appel, M.J. (author), Kuper, C.F. (author), Bessems, J.G.M. (author), Woutersen, R.A. (author), TNO Voeding (author)

The subacute oral and inhalation toxicity of furfural vapour was studied in Fischer 344 rats to investigate whether route-to-route extrapolation could be employed to derive the limit value for inhalation exposure from oral toxicity data. Groups of 5 rats per sex were treated by gavage daily for 28 days at dose levels of 6-192 mg/kg bw/day, or...

article 2004

document

Disposition, accumulation and toxicity of iron fed as iron (II) sulfate or as sodium iron EDTA in rats

Appel, M.J. (author), Kuper, C.F. (author), Woutersen, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

A study was performed to provide data on the disposition, accumulation and toxicity of sodium iron EDTA in comparison with iron (II) sulfate in rats on administration via the diet for 31 and 61 days. Clinical signs, body weights, food consumption, food conversion efficiency, hematology, clinical chemistry and pathology of selected organs were...

article 2001

document

Dietary fat and carcinogenesis

Woutersen, R.A. (author), Appel, M.J. (author), van Garderen-Hoetmer, A. (author), Wijnands, M.V.W. (author), TNO Voeding (author)

Epidemiologic investigations have suggested a relationship between dietary fat intake and various types of cancer incidences. Furthermore, epidemiologic studies as well as studies with animal models have demonstrated that not only the amount but also the type of fat consumed is important. At present, the mechanism by which dietary fat modulates...

article 1999

document

Effect of d-tagatose on liver weight and glycogen content of rats

Bär, A. (author), Lina, B.A.R. (author), de Groot, D.M.G. (author), de Bie, B. (author), Appel, M.J. (author)

article 1999

document

Safety evaluation of synthetic β-carotene

Woutersen, R.A. (author), Wolterbeek, A.P.M. (author), Appel, M.J. (author), van den Berg, H. (author), Goldbohm, R.A. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

The safety of β-carotene was reassessed by evaluating the relevant literature on the beneficial and adverse effects of β-carotene on cancer and, in particular, by evaluating the results of toxicity studies. β- Carotene appeared neither genotoxic nor reprotoxic or teratogenic, and no signs of organ toxicity have been found in subacute, subchronic...

article 1999

document

Modulation of pancreatic carcinogenesis by antioxidants

Woutersen, R.A. (author), Appel, M.J. (author), Garderen van -Hoetmer, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Previously performed short-term (4-month) studies demonstrated that vitamins C and E, β-carotene and selenium modulate growth of early putative preneoplastic acinar lesions induced in rat pancreas by azaserine. The present paper summarizes the results of long-term studies performed with azaserine-treated rats maintained on diets high in either β...

article 1999

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A comparison of the effects of dietary cellulose and fermentable galacto-oligosaccharide, in a rat model of colorectal carcinogenesis: Fermentable fibre confers greater protection than non-fermentable fibre in both high and low fat background

Wijnands, M.V.W. (author), Appel, M.J. (author), Hollanders, V.M.H. (author), Woutersen, R.A. (author), TNO Voeding (author)

The objective of this experiment was to compare the effects of diets with either a non-fermentable fibre source (cellulose) or a fermentable fibre source [galacto-oligosaccharide (GOS)], combined with different levels of dietary fat, on the development of colorectal cancer. Male Wistar rats were fed AIN76-based diets with either a low or high...

article 1999

document

Effect of D-tagatose on liver weight and glycogen content of rats

Bär, A. (author), Lina, B.A.R. (author), de Groot, D.M.G. (author), de Bie, B. (author), Appel, M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

D-Tagatose is an incompletely absorbed ketohexose (stereoisomer of D-fructose) which has potential as an energy-reduced alternative sweetener. In an earlier 90-day toxicity study, rats fed diets with 10, 15 and 20% D-tagatose exhibited increased liver weights, but no histopathological alterations. To determine whether there might be any...

article 1999

document

Modulation of pancreatic carcinogenesis by antioxidants

Woutersen, R.A. (author), Appel, M.J. (author), van Garderen-Hoetmer, A. (author)

article 1999

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Exocrine pancreatic cancer

Bueno-de-Mesquita, H.B. (author), van Kranen, H.J. (author), Appel, M.J. (author), Woutersen, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

bookPart 1998

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Health effects of dietary beta-carotene and selenium

Appel, M.J. (author), Woutersen, R.A. (author), TNO Voeding (author)

conference paper 1996

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Expression of receptors for gut peptides in pancreata of BOP-treated and control hamsters

Tang, C. (author), Biemond, I. (author), Appel, M.J. (author), Visser, C.J.T. (author), Woutersen, R.A. (author), Lamers, C.B.H.W. (author), TNO Voeding (author)

The growth of pancreatic cancers may be influenced by certain gut peptides. However, the alteration of gut peptide receptors in the progress of pancreatic carcinogenesis is largely unknown. With storage phosphor autoradiography, this study visualized and characterized receptors for cholecystokinin (CCK), somatostatin (SST), bombesin (BBS),...

article 1996

document

Cell proliferation and apoptosis in the exocrine pancreas of azaserine-treated rats and N-nitrosobis(2-oxopropyl)amine-treated hamsters: Effects of dietary fish oil

Appel, M.J. (author), Visser, C.J.T. (author), Woutersen, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

Altered cell proliferation is an important characteristic of neoplastic development, hence the quantitation of cell growth in normal and (pre)neoplastic pancreatic tissue will provide useful information on the process (and modulation) of pancreatic tumour promotion in experimental animals. Cell proliferation was estimated by means of BrdU...

article 1996

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Modulation of azaserine-induced pancreatic carcinogenesis in rats by beta-carotene and selenium: Poster paper

Appel, M.J. (author), Woutersen, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Chemicals/CAS: azaserine, 115-02-6; retinol, 68-26-8, 82445-97-4; selenium, 7782-49-2

article 1996

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Lack of inhibitory effects of beta-carotene, vitamin C, vitamin E and selenium on development of ductular adenocarcinomas in exocrine pancreas of hamsters

Appel, M.J. (author), van Garderen-Hoetmer, A. (author), Woutersen, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

The effects of vitamins E and E, β-carotene and selenium on development of N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic tumours in hamsters were investigated. Dietary supplementation of vitamin C, alone as well as in combination with β-carotene resulted in consistently lower numbers of advanced ductular lesions. The differences with...

article 1996