Genetic modulation of coagulation factor VII plasma levels: Contribution of different polymorphisms and gender-related effects

We studied the relationships among different polymorphisms of FVII gene in determining FVII levels, in a sample of 335 male and female Italian volunteers. The hypervariable region 4 (HVR4), the promoter decanucleotide insertion (-323 0/10 bp) and the R353Q polymorphisms of FVII gene were evaluated. The association of HVR4 or -323 0/10 bp...

Bcl I polymorphism in the fibrinogen β-chain gene is associated with the risk of familial myocardial infarction by increasing plasma fibrinogen levels: A case-control study in a sample of GISSI-2 patients

The aim of this study was to investigate the association of the Bcl I β-chain fibrinogen polymorphism with the risk of acute myocardial infarction (AMI) and its relationship with fibrinogen levels in the Italian population. We studied 102 AMI patients, selected within the framework of the GISSI-2 trial, who had a familial history of arterial...

Alterations in urokinase levels and impairment in fibrinolytic system in non-insulin dependent diabetes mellitus (NIDDM) (abstract)

Alu-repeat polymorphism in the tissue-type plasminogen activator (t-PA) gene, t-PA levels and risk of familial myocardial infarction (MI)

Several authors have suggested that increased t-PA antigen levels were associated to thrombotic events in coronary, cerebral and peripheral arteries. Baseline and stimulated levels of t-PA in plasma appear highly heritable, therefore, it could be of interest to evaluate the role of genetic variations in the t-PA locus in determining its plasma...

T-PA and family history of thrombosis in AMI patients from GISSI-trial: Biochemical and genetic aspects

Abstract