Searched for: author%3A%22Alkemade%2C+F.E.%22
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Alkemade, F.E. (author), van Vliet, P. (author), Henneman, P. (author), van Dijk, K.W. (author), Hierck, B.P. (author), van Munsteren, J.C. (author), Scheerman, J.A. (author), Goeman, J.J. (author), Havekes, L.M. (author), Gittenberger-de Groot, A.C. (author), van den Elsen, P.J. (author), de Ruiter, M.C. (author), TNO Kwaliteit van Leven (author)
We recently demonstrated that neointima formation of adult heterozygous apolipoprotein E (apoE+/-) offspring from hypercholesterolemic apoE-/- mothers was significantly increased as compared with genetically identical apoE+/- offspring from normocholesterolemic wild-type mothers. Since atherosclerosis is the consequence of a complex...
article 2010
de Ruiter, M.C. (author), Alkemade, F.E. (author), de Gittenberger - Groot, A.C. (author), Poelmann, R.E. (author), Havekes, L.M. (author), van Dijk, K.W. (author), TNO Kwaliteit van Leven (author)
In this review, we briefly summarize the possible signals crossing the placental barrier and discuss the molecular mechanisms of epigenetic programming in the developing fetus leading to increased athero-susceptibility of the vessel wall. © 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.
article 2008
TNO Kwaliteit van Leven (author), Alkemade, F.E. (author), de Gittenberger-Groot, A.C. (author), Schiel, A.E. (author), van Munsteren, J.C. (author), Hogers, B. (author), van Vliet, L.S.J. (author), Poelmann, R.E. (author), Havekes, L.M. (author), van Dijk, K.W. (author), de Ruiter, M.C. (author)
OBJECTIVE - Maternal hypercholesterolemia is associated with a higher incidence and faster progression of atherosclerotic lesions in neonatal offspring. We aimed to determine whether an in utero environment exposing a fetus to maternal hypercholesterolemia and associated risk factors can prime the murine vessel wall to accelerated development of...
article 2007