Cost-effectiveness of pharmacogenomics in clinical practice: A case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe

Only a few studies have addressed the cost-effectiveness of pharmacogenetics interventions in healthcare. Lack of health economics data on aspects of pharmacogenetics is perceived as one of the barriers hindering its implementation for improving drug safety. Thus, a recent Institute for Prospective Technological Studies (IPTS) study, entitled ...

Cost-effectiveness of 4 neonatal screening strategies for cystic fibrosis

OBJECTIVES. The purpose of this work was to assess the costs of 4 neonatal screening strategies for cystic fibrosis in relation to health effects. In each strategy, the first test was the measurement of serum concentration of immunoreactive trypsin. The second step consisted of either a second immunoreactive trypsin test (strategy 1) or a...

Diagnostisch traject ADHD in regio Zuid-Holland Noord

Case studies and cost-benefit analysis of HER2 and TPMT in four EU member states: part two of an ESTO study on pharmacogenetics and pharmacogenomics: state of the art and social economic impacts

JPB

Cost-effectiveness of different treatment strategies with intrapartum antibiotic prophylaxis to prevent early-onset group B streptococcal disease

Objective: To estimate the costs and effects of different treatment strategies with intrapartum antibiotic prophylaxis to prevent early-onset group B streptococcal (GBS) disease in the Netherlands. The treatment strategies include a risk-based strategy, a screening-based strategy, a combined screening/risk-based strategy and the current Dutch...

Evaluation of cost of disease: Assessing the burden to society of asthma in children in the European Union

Costs associated with persistent allergic rhinitis are reduced by levocetirizine

Background: Allergic rhinitis was recently classified by the ARIA guidelines as persistent or intermittent. Levocetivizine was shown to improve symptoms and health-related quality of life of patients with persistent allergic rhinitis in the XPERT™ study, a 6-month randomized double blind placebo-controlled trial. Objective: To assess the total...

Health and health care for children aged 0-19

Mathematical modelling in evaluation of screening for breast and cervical cancer [Het gebruik van wiskundige modellen bij de evaluatie van bevolkingsonderzoek naar borst- en baarmoederhalskanker]