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Ponec, M. (author), Gibbs, S. (author), GPilgram, G. (author), BoeIsma, E. (author), Koerten, H. (author), Bouwstra, J. (author), Mommaas, M. (author), TNO Voeding (author)
One of the prerequisitesforthe use of human skin equivalents for scientific and screening purposes is that their barrierfunction is similar to that of native skin. Using human epidermis reconstructed en de-epidermized dermis we demonstrated that the formation of the stratum corneum (SC) barrier in vitro proceeds similarly as in vivo as judged...
article 2001
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Diaz, J.V. (author), Anthon, G.E. (author), Barrett, D.M. (author), TNO Kwaliteit van Leven (author)
article 2007
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Brunt, K. (author), Drost, W.C. (author), TNO Kwaliteit van Leven (author)
article 2010
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van Eunen, K. (author), Dool, P. (author), Canelas, AB. (author), Kiewiet, J. (author), Bouwman, J. (author), van Gulik, W.M. (author), Westerhoff, H.V. (author), Bakker, B.M. (author)
In this study, the authors investigated how the glycolytic flux was regulated in time upon nitrogen starvation of cells with different growth histories. We have compared cells grown in glucose-limited chemostat cultures under respiratory conditions (low dilution rate of 0.1/h) to cells grown under respirofermentative conditions (high dilution...
article 2010
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Krul, L. (author), van de Berg, C. (author), TNO Kwaliteit van Leven (author)
article 2010
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Rubingh, C. (author), Thissen, U. (author), van de Voort Maarschalk, K. (author), TNO Kwaliteit van Leven (author)
Statistics are often viewed as confusing and complicated, but multivariate data analysis (MVA) methods can be used to amass knowledge simply. MVA can increase the quality and yield of production processes by elucidating hidden knowledge and identifying opportunities for adaptation using historical or routine data. An application in...
article 2010
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Miller, B.G. (author), Fransman, W. (author), Heederik, D. (author), Hurley, J.F. (author), Kromhout, H. (author), Fitzsimons, E. (author), TNO Kwaliteit van Leven (author)
Purpose Published case–control studies of risks of leukaemia following low exposures to benzene in the distribution of petroleum (gasoline) have not all identiWed the same level of risk, but the studies have had diVerences in cohort inclusion, case determination and availability of occupational and lifestyle data. We reviewed the quality and...
article 2010
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Roeselers, G. (author), Newton, I.L.G. (author), Woyke, T. (author), Auchtung, T.A. (author), Dilly, G.F. (author), Dutton, R.J. (author), Fisher, M.C. (author), Fontanez, K.M. (author), Lau, E. (author), Stewart, F.J. (author), Richardson, P.M. (author), Barry, K.W. (author), Saunders, E. (author), Detter, J.C. (author), Wu, D. (author), Eisen, J.A. (author), Cavanaugh, C.M. (author), TNO Kwaliteit van Leven (author)
article 2010
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van Schalkwijk, D.B. (author), van Bochove, K. (author), van Ommen, B. (author), Freidig, A.P. (author), van Someren, E.P. (author), van der Greef, J. (author), de Graaf, A.A. (author), TNO Kwaliteit van Leven (author)
This article provides methodological and technical considerations to researchers starting to develop computational model-based diagnostics using clinical chemistry data.These models are of increasing importance, since novel metabolomics and proteomics measuring technologies are able to produce large amounts of data that are difficult to...
article 2010
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Braaksma, M. (author), van den Berg, R.A. (author), van der Werf, M.J. (author), Punt, P.J. (author), TNO Kwaliteit van Leven (author)
bookPart 2010
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Woutersen, R.A. (author), Slootweg, P.J. (author), Kuper, C.F. (author), TNO Kwaliteit van Leven (author)
Inhalation toxicity testing is becoming increasingly important, among other things because of the increasing number of drugs that are administered through the intranasal route to avoid enzymatic and acid breakdown and first pass metabolism in the gastrointestinal mucosa and the liver. The nature and site of damage to the nasal mucosa are...
conference paper 2010
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Venema, K. (author), TNO Kwaliteit van Leven (author)
article 2010
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Kuper, C.F. (author), Harleman, H. (author), Schuurman, H.J. (author), TNO Kwaliteit van Leven (author)
conference paper 2010
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Krul, L. (author), Rennen, M. (author), Leeman, W. (author), TNO Kwaliteit van Leven (author)
article 2010
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Blom, W.M. (author), Vlieg-Boerstra, B.J. (author), Spanjersberg, M.I.Q. (author), Kruizinga, A.G. (author), van der Heide, S. (author), Dubois, A.E.J. (author), Houben, G.F. (author), TNO Kwaliteit van Leven (author)
conference paper 2010
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Vermeire, Th. (author), van de Bovenkamp, M. (author), Bruinen de Bruin, Y. (author), Delmaar, Ch. (author), van Engelen, J. (author), Escher, S. (author), Marquart, H. (author), Meijster, T. (author), TNO Kwaliteit van Leven (author)
article 2010
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Boon, F. (author), Meneses, N. (author), Knorr, D. (author), TNO Kwaliteit van Leven (author)
article 2010
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Jacobs, J.F. (author), Punt, C.J. (author), Lesterhuis, W.J. (author), Sutmuller, R.P. (author), Brouwer, H.M. (author), Scharenborg, N.M. (author), Klasen, I.S. (author), Hilbrands, L.B. (author), Figdor, C.G. (author), de Vries, I.J. (author), Adema, G.J. (author), TNO Kwaliteit van Leven (author)
Purpose: The success of cancer immunotherapy depends on the balance between effector T cells and suppressive immune regulatory mechanisms within the tumor microenvironment. In this study we investigated whether transient monoclonal antibody–mediated depletion of CD25high regulatory T cells (Treg) is capable of enhancing the immunostimulatory...
article 2010
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van der Linden, W.J. (author), RKlein Entink, R.H. (author), Fox, J.-P. (author), TNO Kwaliteit van Leven (author)
Hierarchical modeling of responses and response times on test items facilitates the use of response times as collateral information in the estimation of the response parameters. In addition to the regular information in the response data, two sources of collateral information are identified: (a) the joint information in the responses and the...
article 2010
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van der Reijden, W.A. (author), Zaura, E. (author), Keijser, B.J.F. (author), Crielaard, W. (author), TNO Kwaliteit van Leven (author)
article 2010
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