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Ponec, M. (author), Gibbs, S. (author), GPilgram, G. (author), BoeIsma, E. (author), Koerten, H. (author), Bouwstra, J. (author), Mommaas, M. (author), TNO Voeding (author)
One of the prerequisitesforthe use of human skin equivalents for scientific and screening purposes is that their barrierfunction is similar to that of native skin. Using human epidermis reconstructed en de-epidermized dermis we demonstrated that the formation of the stratum corneum (SC) barrier in vitro proceeds similarly as in vivo as judged...
article 2001
document
Notermans, S. (author), Powell, S.C. (author), Hoornstra, E. (author), TNO Kwaliteit van Leven (author)
bookPart 2005
document
Retra, K. (author), van Riet, E. (author), Adegnika, A.A. (author), Everts, B. (author), van Geest, S. (author), Kremsner, P.G. (author), van Hellemond, J.J. (author), van der Kleij, D. (author), Tielens, A.G.M. (author), Yazdanbakhsh, M. (author), TNO Defensie en Veiligheid (author)
Schistosomes carry lipid moieties that interact with the immune system. To understand the consequence of interactions in terms of polarizing the cytokine profiles, the effect of two Toll-like receptor-2 (TLR2) activating schistosomal lipid fractions was studied on whole blood from Gabonese children living in a schistosomiasis endemic area. One...
article 2008
document
Joosten, M.M. (author), Hendriks, H.F.J. (author)
article 2010
document
van Tol, E.A.F. (author), Russell, W.M. (author), Herz, U. (author), Renz, H. (author), Garn, H. (author), Braaksma, M. (author), van der Werf, M.J. (author), Overkamp, K.M. (author)
patent 2011
document
Kamphuis, M. (author), van Leerdam, F.J.M. (author), Wierenga-van der Hoeven, C.J. (author), Bulk-Bunschoten, A.W.W. (author), Deurloo, J.A. (author), Beltman, M. (author)
De JGZ kan voorlichting geven over zindelijkheid aan ouders en kinderen en zindelijkheidsproblemen signaleren en begeleiden. Doel van deze richtlijn is het uniform, tijdig en correct signaleren, verwijzen en begeleiden van kinderen met zindelijkheidsproblemen door de JGZ. Ook kan de JGZ een rol spelen in de voorlichting aan de omgeving van het...
report 2011
document
Lanting, C.I. (author), van Wouwe, J.P. (author), van den Burg, I. (author), Segaar, D. (author), van der Pal-de Bruin, K.M. (author)
Doel. Het vaststellen van trends in de rookprevalentie onder zwangeren in de periode 2001-2010 en deze prevalentie relateren aan verschillen naar opleidingsniveau. Opzet. Beschrijvend; landelijke peilingen. Methode. In 2001, 2002, 2003, 2005, 2007 en 2010 werden via organisaties voor jeugdgezondheidszorg tijdens het periodiek...
article 2012
document
Fleuren, M.A.H. (author), TNO Kwaliteit van Leven (author)
other 2012
document
Rose, R.J. (author), Thompson, N.J. (author), Van Duijn, E. (author), Damoc, E. (author), Denisov, E. (author), Makarov, A. (author), Heck, A.J.R. (author)
Monoclonal antibodies (mAbs) represent a major class of therapeutic biomolecules being developed by the biopharmaceutical industry, their popularity largely being a result of their high specificity towards targets. Therapeutic mAbs are being developed for various diseases, with a strong focus on cancer and immunological disorders.[1] All...
article 2012
document
Schokker, D.F. (author), Dusseldorp, E. (author), van Genugten, L. (author), Verheijden, M.W. (author), van Empelen, P. (author), TNO Kwaliteit van Leven (author)
Voldoende beweging en goede voeding zijn van belang voor de gezondheid. Om mensen te stimuleren tot een gezonde leefstijl worden interventies ingezet. Steeds vaker worden hierbij combinaties van methodieken gebruikt. TNO heeft een nieuwe analysetechniek ingezet om zicht te krijgen op succesvolle combinaties van methodieken. Met deze kennis...
other 2012
document
Berges, M. (author), Brouwer, D.H. (author), Hodson, L. (author), Asbach, C. (author), Bard, D. (author), Lynch, I. (author), Riediker, M. (author)
article 2012
document
van Bilsen, J.H. (author), Knippels, L.M. (author), Penninks, A.H. (author), Nieuwenhuizen, W.F. (author), de Jongh, H.H. (author), Koppelman, S.J. (author)
It is not exactly known why certain food proteins are more likely to sensitize. One of the characteristics of most food allergens is that they are stable to the acidic and proteolytic conditions in the digestive tract. This property is thought to be a risk factor in allergic sensitization. The purpose of the present study was to investigate the...
article 2013
document
van der Ploeg, C.P.B. (author), Schönbeck, Y. (author), Hirschberg, H. (author)
In deze rapportage worden de belangrijkste resultaten beschreven van het bevolkingsonderzoek PSIE voor 2012 in vergelijking met voorgaande jaren. De monitor omvat de gegevens van zwangeren met een bloedafnamedatum van het eerste bloedonderzoek voor de PSIE in 2012. Dit eerste onderzoek wordt voor of in zwangerschapsweek 12 gedaan. Vervolgstappen...
report 2013
document
Trip, H. (author), Niemcewicz, M. (author), Sellek, R. (author), Heng, J.M. (author), Mars-Groenendijk, R.H. (author), de Jong, A.L. (author), Majchrzykiewicz, J.A. (author), Olsen, J.S. (author), Tsivtsivadze, E. (author), Paauw, A. (author)
conference paper 2013
document
Majchrzykiewicz-Koehorst, J.A. (author), Coenjaerts, F. (author), Trip, H. (author), Jong, A.L. (author), Hulst, A.G. (author), Heikens, E. (author), Paauw, A. (author)
conference paper 2013
document
Kuper, C.F. (author), Ruehl-Fehlert, C. (author), Elmore, S.A. (author), Parker, G.A. (author)
Cells of the immune system are found in every organ, from the classic lymphoid organs to tissues such as liver, mucosae, and omental adipose tissue. Toxicity to the immune system may be from a direct or indirect injury to lymphoid organs. The morphological responses range from lymphocyte depletion to proliferation, and may result in an increased...
bookPart 2013
document
Nieuwland, M. (author), Ruizendaal, L. (author), Brinkmann, A. (author), Kroon-Batenburg, L. (author), van Hest, J.C.M. (author), Lowik, D.W.P.M. (author)
article 2013
document
Aranda, A. (author), Sequedo, L. (author), Tolosa, L. (author), Quintas, G. (author), Burello, E. (author), Castell, J.V. (author), Gombau, L. (author)
No consensus exists on how to address possible toxicity of nanomaterials as they interfere with most in vitro screening tests based on colorimetric and fluorimetric probes such as the dichloro-dihydrofluorescein diacetate (DCFH-DA) assay for detection of oxidative species. In the present research, nanomaterial interaction with DCFH-DA was...
article 2013
document
Perron, H. (author), Germi, R. (author), Bernard, C. (author), Garcia-Montojo, M. (author), Deluen, C. (author), Farinelli, L. (author), Faucard, R. (author), Veas, F. (author), Stefas, I. (author), Fabriek, B.O. (author), Van-Horssen, J. (author), Vander-Valk, P. (author), Gerdil, C. (author), Mancuso, R. (author), Saresella, M. (author), Clerici, M. (author), Marcel, S. (author), Creange, A. (author), Cavaretta, R. (author), Caputo, D. (author), Arru, G. (author), Morand, P. (author), Lang, A.B. (author), Sotgiu, S. (author), Ruprecht, K. (author), Rieckmann, P. (author), Villoslada, P. (author), Chofflon, M. (author), Boucraut, J. (author), Pelletier, J. (author), Hartung, H.P. (author)
article 2013
document
Crevel, R.W.R. (author), Ballmer-Weber, B.K. (author), Taylor, S.L. (author), Houben, G.F. (author), Mills, C. (author)
Thresholds for allergenic foods constitute a key element in characterizing the hazard and assessing the risk to allergic consumers from those foods. Threshold determination for key allergenic foods in Europe was identified as a major element and deliverable in the EuroPrevall work program. The value of this work was based on the twin foundations...
bookPart 2013
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