Searched for: +
(1 - 20 of 2,487)

Pages

document
Ponec, M. (author), Gibbs, S. (author), GPilgram, G. (author), BoeIsma, E. (author), Koerten, H. (author), Bouwstra, J. (author), Mommaas, M. (author), TNO Voeding (author)
One of the prerequisitesforthe use of human skin equivalents for scientific and screening purposes is that their barrierfunction is similar to that of native skin. Using human epidermis reconstructed en de-epidermized dermis we demonstrated that the formation of the stratum corneum (SC) barrier in vitro proceeds similarly as in vivo as judged...
article 2001
document
Notermans, S. (author), Powell, S.C. (author), Hoornstra, E. (author), TNO Kwaliteit van Leven (author)
bookPart 2005
document
Diaz, J.V. (author), Anthon, G.E. (author), Barrett, D.M. (author), TNO Kwaliteit van Leven (author)
article 2007
document
Retra, K. (author), van Riet, E. (author), Adegnika, A.A. (author), Everts, B. (author), van Geest, S. (author), Kremsner, P.G. (author), van Hellemond, J.J. (author), van der Kleij, D. (author), Tielens, A.G.M. (author), Yazdanbakhsh, M. (author), TNO Defensie en Veiligheid (author)
Schistosomes carry lipid moieties that interact with the immune system. To understand the consequence of interactions in terms of polarizing the cytokine profiles, the effect of two Toll-like receptor-2 (TLR2) activating schistosomal lipid fractions was studied on whole blood from Gabonese children living in a schistosomiasis endemic area. One...
article 2008
document
Bonsen, I.M. (author), Gaasbeek, R.C. (author), TNO Defensie en Veiligheid (author)
Current approaches in critical infrastructure protection use long lists of items that fail to give its user a structured answer to the state of protection of its object. The functionality approach uses different terrorist functions to structure the threat (which are to have intent, to scout, to transport, to attack and to have an effect). It...
conference paper 2009
document
Brunt, K. (author), Drost, W.C. (author), TNO Kwaliteit van Leven (author)
article 2010
document
van Eunen, K. (author), Dool, P. (author), Canelas, AB. (author), Kiewiet, J. (author), Bouwman, J. (author), van Gulik, W.M. (author), Westerhoff, H.V. (author), Bakker, B.M. (author)
In this study, the authors investigated how the glycolytic flux was regulated in time upon nitrogen starvation of cells with different growth histories. We have compared cells grown in glucose-limited chemostat cultures under respiratory conditions (low dilution rate of 0.1/h) to cells grown under respirofermentative conditions (high dilution...
article 2010
document
den Hartog, E.A. (author), TNO Defensie en Veiligheid (author)
article 2010
document
Krul, L. (author), van de Berg, C. (author), TNO Kwaliteit van Leven (author)
article 2010
document
Rose, D.J. (author), Venema, K. (author), Keshavarzian, A. (author), Hamaker, B.R. (author), TNO Kwaliteit van Leven (author), KvL (author)
article 2010
document
Rubingh, C. (author), Thissen, U. (author), van de Voort Maarschalk, K. (author), TNO Kwaliteit van Leven (author)
Statistics are often viewed as confusing and complicated, but multivariate data analysis (MVA) methods can be used to amass knowledge simply. MVA can increase the quality and yield of production processes by elucidating hidden knowledge and identifying opportunities for adaptation using historical or routine data. An application in...
article 2010
document
Miller, B.G. (author), Fransman, W. (author), Heederik, D. (author), Hurley, J.F. (author), Kromhout, H. (author), Fitzsimons, E. (author), TNO Kwaliteit van Leven (author)
Purpose Published case–control studies of risks of leukaemia following low exposures to benzene in the distribution of petroleum (gasoline) have not all identiWed the same level of risk, but the studies have had diVerences in cohort inclusion, case determination and availability of occupational and lifestyle data. We reviewed the quality and...
article 2010
document
Roeselers, G. (author), Newton, I.L.G. (author), Woyke, T. (author), Auchtung, T.A. (author), Dilly, G.F. (author), Dutton, R.J. (author), Fisher, M.C. (author), Fontanez, K.M. (author), Lau, E. (author), Stewart, F.J. (author), Richardson, P.M. (author), Barry, K.W. (author), Saunders, E. (author), Detter, J.C. (author), Wu, D. (author), Eisen, J.A. (author), Cavanaugh, C.M. (author), TNO Kwaliteit van Leven (author)
article 2010
document
van Schalkwijk, D.B. (author), van Bochove, K. (author), van Ommen, B. (author), Freidig, A.P. (author), van Someren, E.P. (author), van der Greef, J. (author), de Graaf, A.A. (author), TNO Kwaliteit van Leven (author)
This article provides methodological and technical considerations to researchers starting to develop computational model-based diagnostics using clinical chemistry data.These models are of increasing importance, since novel metabolomics and proteomics measuring technologies are able to produce large amounts of data that are difficult to...
article 2010
document
van Wijk, R. (author), van der Greef, J. (author), van Wijk, E. (author), TNO Kwaliteit van Leven (author)
The relationship between connective tissue and meridian function is discussed in terms of energy transmission. The network of hydrogen-bonded water molecules interspersed within the collagen fibrillar matrix is especially significant for both the sensitivity of connective tissue to weak signals of mechanical pressure, heat, or electricity and...
article 2010
document
Tsuji, F. (author), Murai, M. (author), Oki, K. (author), Seki, I. (author), Ueda, K. (author), Inoue, H. (author), Nagelkerken, L. (author), Sasano, M. (author), Aono, H. (author), TNO Kwaliteit van Leven (author)
We recently demonstrated that SA13353 [1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea], a novel transient receptor potential vanilloid 1 (TRPV1) agonist, inhibits TNF-α production through the activation of capsaicin-sensitive afferent neurons. In the present study, we investigated the effects of SA13353 on lipopolysaccharide (LPS)...
article 2010
document
Joosten, M.M. (author), Hendriks, H.F.J. (author)
article 2010
document
Braaksma, M. (author), van den Berg, R.A. (author), van der Werf, M.J. (author), Punt, P.J. (author), TNO Kwaliteit van Leven (author)
bookPart 2010
document
van der Schans, M.J. (author), Joosen, M.J.A. (author), van den Berg, R.M. (author), Chau, L.F. (author), Noort, D. (author), Langenberg, J.P. (author), TNO Defensie en Veiligheid (author)
conference paper 2010
document
Woutersen, R.A. (author), Slootweg, P.J. (author), Kuper, C.F. (author), TNO Kwaliteit van Leven (author)
Inhalation toxicity testing is becoming increasingly important, among other things because of the increasing number of drugs that are administered through the intranasal route to avoid enzymatic and acid breakdown and first pass metabolism in the gastrointestinal mucosa and the liver. The nature and site of damage to the nasal mucosa are...
conference paper 2010
Searched for: +
(1 - 20 of 2,487)

Pages