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Ponec, M. (author), Gibbs, S. (author), GPilgram, G. (author), BoeIsma, E. (author), Koerten, H. (author), Bouwstra, J. (author), Mommaas, M. (author), TNO Voeding (author)
One of the prerequisitesforthe use of human skin equivalents for scientific and screening purposes is that their barrierfunction is similar to that of native skin. Using human epidermis reconstructed en de-epidermized dermis we demonstrated that the formation of the stratum corneum (SC) barrier in vitro proceeds similarly as in vivo as judged...
article 2001
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Retra, K. (author), van Riet, E. (author), Adegnika, A.A. (author), Everts, B. (author), van Geest, S. (author), Kremsner, P.G. (author), van Hellemond, J.J. (author), van der Kleij, D. (author), Tielens, A.G.M. (author), Yazdanbakhsh, M. (author), TNO Defensie en Veiligheid (author)
Schistosomes carry lipid moieties that interact with the immune system. To understand the consequence of interactions in terms of polarizing the cytokine profiles, the effect of two Toll-like receptor-2 (TLR2) activating schistosomal lipid fractions was studied on whole blood from Gabonese children living in a schistosomiasis endemic area. One...
article 2008
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Joosten, M.M. (author), Hendriks, H.F.J. (author)
article 2010
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Lanting, C.I. (author), van Wouwe, J.P. (author), van den Burg, I. (author), Segaar, D. (author), van der Pal-de Bruin, K.M. (author)
Doel. Het vaststellen van trends in de rookprevalentie onder zwangeren in de periode 2001-2010 en deze prevalentie relateren aan verschillen naar opleidingsniveau. Opzet. Beschrijvend; landelijke peilingen. Methode. In 2001, 2002, 2003, 2005, 2007 en 2010 werden via organisaties voor jeugdgezondheidszorg tijdens het periodiek...
article 2012
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Rose, R.J. (author), Thompson, N.J. (author), Van Duijn, E. (author), Damoc, E. (author), Denisov, E. (author), Makarov, A. (author), Heck, A.J.R. (author)
Monoclonal antibodies (mAbs) represent a major class of therapeutic biomolecules being developed by the biopharmaceutical industry, their popularity largely being a result of their high specificity towards targets. Therapeutic mAbs are being developed for various diseases, with a strong focus on cancer and immunological disorders.[1] All...
article 2012
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Berges, M. (author), Brouwer, D.H. (author), Hodson, L. (author), Asbach, C. (author), Bard, D. (author), Lynch, I. (author), Riediker, M. (author)
article 2012
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van Bilsen, J.H. (author), Knippels, L.M. (author), Penninks, A.H. (author), Nieuwenhuizen, W.F. (author), de Jongh, H.H. (author), Koppelman, S.J. (author)
It is not exactly known why certain food proteins are more likely to sensitize. One of the characteristics of most food allergens is that they are stable to the acidic and proteolytic conditions in the digestive tract. This property is thought to be a risk factor in allergic sensitization. The purpose of the present study was to investigate the...
article 2013
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Nieuwland, M. (author), Ruizendaal, L. (author), Brinkmann, A. (author), Kroon-Batenburg, L. (author), van Hest, J.C.M. (author), Lowik, D.W.P.M. (author)
article 2013
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Aranda, A. (author), Sequedo, L. (author), Tolosa, L. (author), Quintas, G. (author), Burello, E. (author), Castell, J.V. (author), Gombau, L. (author)
No consensus exists on how to address possible toxicity of nanomaterials as they interfere with most in vitro screening tests based on colorimetric and fluorimetric probes such as the dichloro-dihydrofluorescein diacetate (DCFH-DA) assay for detection of oxidative species. In the present research, nanomaterial interaction with DCFH-DA was...
article 2013
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Perron, H. (author), Germi, R. (author), Bernard, C. (author), Garcia-Montojo, M. (author), Deluen, C. (author), Farinelli, L. (author), Faucard, R. (author), Veas, F. (author), Stefas, I. (author), Fabriek, B.O. (author), Van-Horssen, J. (author), Vander-Valk, P. (author), Gerdil, C. (author), Mancuso, R. (author), Saresella, M. (author), Clerici, M. (author), Marcel, S. (author), Creange, A. (author), Cavaretta, R. (author), Caputo, D. (author), Arru, G. (author), Morand, P. (author), Lang, A.B. (author), Sotgiu, S. (author), Ruprecht, K. (author), Rieckmann, P. (author), Villoslada, P. (author), Chofflon, M. (author), Boucraut, J. (author), Pelletier, J. (author), Hartung, H.P. (author)
article 2013
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Noort, D. (author), Langenberg, J.P. (author), van der Schans, M.J. (author)
Dr. Henk P. Benschop was born on September 19, 1939. He started his scientific career at TNO in May 1964, as an alternative for regular military duty. In 1972, he obtained his PhD on the Thesis entitled: Stereochemistry of optically active alkyl alkylphosphinates. Henk spent a postdoctoral year with Professor Halmann at the Weizmann Institute of...
article 2013
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Kruizinga, A.G. (author), Klein Entink, R.H. (author), Blom, W.M. (author), Houben, G.F. (author), van Bilsen, J.H.M. (author)
article 2013
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Blatchford, P. (author), Ansell, J. (author), de Godoy, M.R.C. (author), Fahey, G. (author), Garcia-Mazcorro, J.F. (author), Gibson, G.R. (author), Goh, Y.J. (author), Hotchkiss, A.T. (author), Hutkins, R. (author), LaCroix, C. (author), Rastall, R.A. (author), Reimer, R.A. (author), Schoterman, M. (author), Van Sinderen, D. (author), Venema, K. (author), Whelan, K. (author)
In October 2012, a group of scientists met at the 10th Meeting of the International Scientific Association of Probiotics and Prebiotics (ISAPP) in Cork, Ireland to discuss issues surrounding prebiotics and their development. This article summarises outputs from the meeting. Various prebiotic definitions were discussed and how the concept has...
article 2013
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Krishnan, S. (author), Kerkhoff, H.G. (author)
Stringent quality requirements on final electronic products are continuously forcing semiconductor industries, especially the automobile industry, to insert additional reliability tests in their production flow. The problem with linear regressions models for outlier identification in analog and RF devices is that they do not generally account...
article 2013
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Michelsen-Huisman, A.D. (author), van Os-Medendorp, H. (author), Versluis, A. (author), Kruizinga, A.G. (author), Castenmiller, J.J.M. (author), Noteborn, H.P.J.M. (author), Houben, G.F. (author), Knulst, A.C. (author)
Unexpected reactions occur in patients with food allergy, but frequency data are scare. This prospective study investigates the frequency, severity and causes of unexpected allergic reactions to food in adults with a doctor's diagnosed food allergy. Participants complete an online questionnaire after every unexpected reaction and send in the...
article 2013
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de Boer, P. (author), Bronkhof, J. (author), Duki, K. (author), Kerkman, R. (author), Touw, H. (author), van den Berg, M. (author), Offringa, R. (author)
The industrial production of β-lactam antibiotics by Penicillium chrysogenum has increased tremendously over the last decades, however, further optimization via classical strain and process improvement has reached its limits. The availability of the genome sequence provides new opportunities for directed strain improvement, but this requires the...
article 2013
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Blom, W.M. (author), Houben, G.F. (author)
The unintentional presence of allergens in prepacked foods caused by cross contact is a problem for food allergic patients and food producers. The labelling of products with a precautionary label such as ‘May contain traces of ...’ shows a poor correlation with the actual presence or absence of food allergens due to cross contact of products....
article 2013
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Remington, B.C. (author), Blom, W.M. (author), Houben, G.F. (author), Knulst, A.C. (author), Baumert, J.L. (author), Taylor, S.L. (author)
article 2013
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Berbée, J.F.P. (author), Wong, M.C. (author), Wang, Y. (author), van der Hoorn, J.W.A. (author), Khedoe, P.P.S.J. (author), van Klinken, J.B. (author), Mol, I.M. (author), Hiemstra, P.S. (author), Tsikas, D. (author), Romijn, J.A. (author), Havekes, L.M. (author), Princen, H.M.G. (author), Rensen, P.C.N. (author)
Resveratrol is a major constituent of traditional Asian medicinal herbs and red wine and is suggested to be a potential antiatherosclerotic drug due to its proposed hypolipidemic, anti-inflammatory and antioxidative properties. The aim of this study was to evaluate whether resveratrol protects against atherosclerosis development in APOE*. 3...
article 2013
document
Heeres, H.L. (author)
article 2013
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