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Ponec, M. (author), Gibbs, S. (author), GPilgram, G. (author), BoeIsma, E. (author), Koerten, H. (author), Bouwstra, J. (author), Mommaas, M. (author), TNO Voeding (author)
One of the prerequisitesforthe use of human skin equivalents for scientific and screening purposes is that their barrierfunction is similar to that of native skin. Using human epidermis reconstructed en de-epidermized dermis we demonstrated that the formation of the stratum corneum (SC) barrier in vitro proceeds similarly as in vivo as judged...
article 2001
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Diaz, J.V. (author), Anthon, G.E. (author), Barrett, D.M. (author), TNO Kwaliteit van Leven (author)
article 2007
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Retra, K. (author), van Riet, E. (author), Adegnika, A.A. (author), Everts, B. (author), van Geest, S. (author), Kremsner, P.G. (author), van Hellemond, J.J. (author), van der Kleij, D. (author), Tielens, A.G.M. (author), Yazdanbakhsh, M. (author), TNO Defensie en Veiligheid (author)
Schistosomes carry lipid moieties that interact with the immune system. To understand the consequence of interactions in terms of polarizing the cytokine profiles, the effect of two Toll-like receptor-2 (TLR2) activating schistosomal lipid fractions was studied on whole blood from Gabonese children living in a schistosomiasis endemic area. One...
article 2008
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Brunt, K. (author), Drost, W.C. (author), TNO Kwaliteit van Leven (author)
article 2010
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van Eunen, K. (author), Dool, P. (author), Canelas, AB. (author), Kiewiet, J. (author), Bouwman, J. (author), van Gulik, W.M. (author), Westerhoff, H.V. (author), Bakker, B.M. (author)
In this study, the authors investigated how the glycolytic flux was regulated in time upon nitrogen starvation of cells with different growth histories. We have compared cells grown in glucose-limited chemostat cultures under respiratory conditions (low dilution rate of 0.1/h) to cells grown under respirofermentative conditions (high dilution...
article 2010
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den Hartog, E.A. (author), TNO Defensie en Veiligheid (author)
article 2010
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Krul, L. (author), van de Berg, C. (author), TNO Kwaliteit van Leven (author)
article 2010
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Rose, D.J. (author), Venema, K. (author), Keshavarzian, A. (author), Hamaker, B.R. (author), TNO Kwaliteit van Leven (author), KvL (author)
article 2010
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Rubingh, C. (author), Thissen, U. (author), van de Voort Maarschalk, K. (author), TNO Kwaliteit van Leven (author)
Statistics are often viewed as confusing and complicated, but multivariate data analysis (MVA) methods can be used to amass knowledge simply. MVA can increase the quality and yield of production processes by elucidating hidden knowledge and identifying opportunities for adaptation using historical or routine data. An application in...
article 2010
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Miller, B.G. (author), Fransman, W. (author), Heederik, D. (author), Hurley, J.F. (author), Kromhout, H. (author), Fitzsimons, E. (author), TNO Kwaliteit van Leven (author)
Purpose Published case–control studies of risks of leukaemia following low exposures to benzene in the distribution of petroleum (gasoline) have not all identiWed the same level of risk, but the studies have had diVerences in cohort inclusion, case determination and availability of occupational and lifestyle data. We reviewed the quality and...
article 2010
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Roeselers, G. (author), Newton, I.L.G. (author), Woyke, T. (author), Auchtung, T.A. (author), Dilly, G.F. (author), Dutton, R.J. (author), Fisher, M.C. (author), Fontanez, K.M. (author), Lau, E. (author), Stewart, F.J. (author), Richardson, P.M. (author), Barry, K.W. (author), Saunders, E. (author), Detter, J.C. (author), Wu, D. (author), Eisen, J.A. (author), Cavanaugh, C.M. (author), TNO Kwaliteit van Leven (author)
article 2010
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van Schalkwijk, D.B. (author), van Bochove, K. (author), van Ommen, B. (author), Freidig, A.P. (author), van Someren, E.P. (author), van der Greef, J. (author), de Graaf, A.A. (author), TNO Kwaliteit van Leven (author)
This article provides methodological and technical considerations to researchers starting to develop computational model-based diagnostics using clinical chemistry data.These models are of increasing importance, since novel metabolomics and proteomics measuring technologies are able to produce large amounts of data that are difficult to...
article 2010
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van Wijk, R. (author), van der Greef, J. (author), van Wijk, E. (author), TNO Kwaliteit van Leven (author)
The relationship between connective tissue and meridian function is discussed in terms of energy transmission. The network of hydrogen-bonded water molecules interspersed within the collagen fibrillar matrix is especially significant for both the sensitivity of connective tissue to weak signals of mechanical pressure, heat, or electricity and...
article 2010
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Tsuji, F. (author), Murai, M. (author), Oki, K. (author), Seki, I. (author), Ueda, K. (author), Inoue, H. (author), Nagelkerken, L. (author), Sasano, M. (author), Aono, H. (author), TNO Kwaliteit van Leven (author)
We recently demonstrated that SA13353 [1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea], a novel transient receptor potential vanilloid 1 (TRPV1) agonist, inhibits TNF-α production through the activation of capsaicin-sensitive afferent neurons. In the present study, we investigated the effects of SA13353 on lipopolysaccharide (LPS)...
article 2010
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Joosten, M.M. (author), Hendriks, H.F.J. (author)
article 2010
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Venema, K. (author), TNO Kwaliteit van Leven (author)
article 2010
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Vlaanderen, J. (author), Fransman, W. (author), Miller, B. (author), Burstyn, I. (author), Heederik, D. (author), Hurley, F. (author), Vermeulen, R. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)
Introduction: In occupational epidemiology, differences in the temporal coverage of the exposure history by available exposure measurement data may affect the uncertainty of exposure estimates. In the reporting of results of studies, greater attention should be paid to the extent to which exposure assessments require extrapolation outside the...
article 2010
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Schoen, E.D. (author), TNO Industrie en techniek (author)
Designs with full estimation capacity permit estimation of all main effects and all two-factor interactions. By allowing correlation among the effects, the run size of such designs can be smaller than required for a resolution of 5. To construct a design, one can either use commercial software for designs with optimized D-efficiencies or a...
article 2010
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Krul, L. (author), Rennen, M. (author), Leeman, W. (author), TNO Kwaliteit van Leven (author)
article 2010
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Vermeire, Th. (author), van de Bovenkamp, M. (author), Bruinen de Bruin, Y. (author), Delmaar, Ch. (author), van Engelen, J. (author), Escher, S. (author), Marquart, H. (author), Meijster, T. (author), TNO Kwaliteit van Leven (author)
article 2010
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