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Oostvogel, P.M. (author), van Conyn-Spaendonck, M.A.E. (author), Hirasing, R.A. (author), van Loon, A.M. (author), TNO Preventie en Gezondheid (author)
report 1996
document
Jonkman, E.J. (author), Mosmans, P.C.M. (author)
other 1977
document
Löwik, M.R.H. (author), Hulshof, K.F.A.M. (author), Brussaard, J.H. (author), Brants, H.A.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
conference paper 1996
document
Burgmeijer, R.J.F. (author), van Wieringen, J.C. (author)
bookPart 1998
document
van Dokkum, W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
bookPart 1998
document
Mooijaart, S.P. (author), van Vliet, P. (author), van Heemst, D. (author), Rensen, P.C.N. (author), Berbée, J.F.P. (author), Jolles, J. (author), de Craen, A.J.M. (author), Westendorp, R.G.J. (author), TNO Kwaliteit van Leven (author)
The relationship between structural variants of the apolipoprotein E gene, APOE ε2/ε3/ε4, and dementia is well established, whereas the relationship of plasma apoE levels with dementia is less clear. Plasma apoE levels are under tight genetic control but vary widely within the various genotypes indicating that the APOE ε2/ε3/ε4 locus explains...
bookPart 2007
document
van Vliet, P. (author), Mooijaart, S.P. (author), de Craen, A.J.M. (author), Rensen, P.C.N. (author), van Heemst, D. (author), Westendorp, R.G.J. (author), TNO Kwaliteit van Leven (author)
Recently, high plasma apoE levels have been shown to be related to increased cardiovascular mortality, independent of APOE genotype. Here we studied the association of plasma apoE levels with risk of stroke. Within the Leiden 85-plus Study, a prospective population-based study of 561 subjects aged 85 years, we measured plasma apoE level and...
bookPart 2007
document
Richardus, J.H. (author), Graafmans, W.C. (author), van der Pal-de Bruin, K.M. (author), Amelink-Verburg, M.P. (author), Verloove-Vanhorick, S.P. (author), Mackenbach, J.P. (author), TNO Preventie en Gezondheid (author)
In this paper the concepts, objectives, design, and data analysis procedures of the EuroNatal study are described. This sutdy started in 1996 and is a concerted action including 14 countries in Europe. The EuroNatal study aims at determining the validity of national perinatal mortality rates as an outcome indicator for the quality of antenatal...
article 1997
document
Virtanen, S.M. (author), van 't Veer, P. (author), Kok, F. (author), Kardinaal, A.F.M. (author), Aro, A. (author), EURAMIC Study Group (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To evaluate the levels of adipose tissue alpha-tocopherol, gamma-tocopherol, and toenail selenium and their determinants. Design: Control subjects from multicentre case-control study on antioxidants, myocardial infarction and cancer of the breast. Subjects and setting: 686 male and 339 female middle-aged and elderly subjects from...
article 1996
document
Männistö, S. (author), Yaun, S.S. (author), Hunter, D.J. (author), Spiegelman, D. (author), Adami, H.O. (author), Albanes, D. (author), van den Brandt, P.A. (author), Buring, J.E. (author), Cerhan, J.R. (author), Colditz, G.A. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Harnack, L. (author), Leitzmann, M. (author), McCullough, M.L. (author), Miller, A.B. (author), Rohan, T.E. (author), Schatzkin, A. (author), Virtamo, J. (author), Willett, W.C. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)
Dietary carotenoids have been hypothesized to protect against epithelial cancers. The authors analyzed the associations between intakes of specific carotenoids (alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein + zeaxanthin, and lycopene) and risk of colorectal cancer using the primary data from 11 cohort studies carried out in North...
article 2007
document
Schrama, J.W. (author), Bakker, G.C.M. (author)
Fermentable nonstarch polysaccharides (dietary fiber) affect energy retention in group-housed growing pigs by reducing physical activity. This study assessed the effects of fermentation and bulkiness of dietary carbohydrates on physical activity in relation to energy metabolism. Eight clusters of 14 pigs were fed one of four diets in a 2 × 2...
article 1999
document
Fabriek, B.O. (author), Møller, H.J. (author), Vloet, R.P.M. (author), van Winsen, L.M. (author), Hanemaaijer, R. (author), Teunissen, C.E. (author), Uitdehaag, B.M.J. (author), van den Berg, T.K. (author), Dijkstra, C.D. (author), TNO Kwaliteit van Leven (author)
The scavenger receptor CD163 is selectively expressed on tissue macrophages and human monocytes. CD163 has been implicated to play a role in the clearance of hemoglobin and in the regulation of cytokine production by macrophages. Membrane CD163 can be cleaved by matrix metalloproteinases (MMP) resulting in soluble CD163 (sCD163). In the present...
article 2007
document
Walraven, P.L. (author), Instituut voor Zintuigfysiologie TNO (author)
On the basis of new experimental data of tritanopic vision the convergence centre for tritanopia has been redetermined, and has turned out to bex' = 0.1747,y' = 0.0060 in the Judd 1951-chromaticity diagram. A consequence of this determination is that the blue system is more sensitive than was concluded from the Thomson-Wright (1953) study. The...
article 1974
document
Barth, P.G. (author), Hirasing, R.A. (author), TNO Preventie en Gezondheid (author)
The prevalence of the severe disease spina bifida is decreasing, but the present rate is still unacceptably high. Only one-third of women planning motherhood use the recommended folic acid, although compliance is increasing. Campaigns for the use of folic acid by these women should be intensified. This method, however, cannot completely prevent...
article 2000
document
Fransman, W. (author), Roeleveld, N. (author), Peelen, S. (author), de Kort, W. (author), Kromhout, H. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
BACKGROUND: Nurses and other hospital workers are exposed to antineoplastic drugs during daily activities. Previous studies suggest that antineoplastic drugs at occupational exposure levels may be toxic to reproduction, but these studies are not consistent or conclusive. METHODS: Self-administered questionnaires were completed by 4393 exposed...
article 2007
document
Reijneveld, S.A. (author), Harland, P. (author), Brugman, E. (author), Verhulst, F.C. (author), Verloove-Vanhorick, S.P. (author)
Background This study aims to examine a) the prevalence of psychosocial problems and b) the association between parent-reported problems and the identification by doctors and nurses (child health professionals, CHP) working in preventive child health care, among immigrant and non-immigrant children. Methods CHPs examined 4,098 children aged 5...
article 2005
document
Visser, J. (author), Lentjes, E. (author), Haspels, I. (author), Graffelman, W. (author), Blauw, B. (author), de Kloet, R. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
Background: In this study we tested the hypothesis that the increased sensitivity to glucocorticoids in chronic fatigue syndrome (CFS)-patients can be attributed to an altered functioning of their glucocorticoid receptors (GR). Methods: For this purpose, affinity and distribution of the GR were studied in purified, peripheral blood mononuclear...
article 2001
document
Nijhuis, E.W.P. (author), Oostervink, F. (author), Hinloopen, B. (author), Rozing, J. (author), Nagelkerken, L. (author), Gaubius Instituut TNO (author)
Peripheral blood mononuclear cells (PBMC) from 40 consecutive patients entering a screening program on cognitive impairment were studied in vitro with respect to their sensitivity to dexamethasone (DEX). Phytohemagglutinin-induced proliferation by PBMC from patients with senile dementia of the Alzheimer type (SDAT) was less sensitive to the...
article 1996
document
Hopman-Rock, M. (author), de Bock, G.H. (author), Bijlsma, J.W.J. (author), Springer, M.P. (author), Hofman, A. (author), Kraaimaat, F.W. (author), TNO Preventie en Gezondheid (author)
Objective: The aim of the study was to determine the pattern of health care utilization of people aged 55-74 years with arthritic pain in the knee or hip. Design: People with current pain were identified in a population- based study. A filter model was used to describe the pattern of health care utilization of people who presented as patients at...
article 1997
document
Proper, K.I. (author), Hildebrandt, V.H. (author), van der Beek, A.J. (author), Twisk, J.W.R. (author), van Mechelen, W. (author)
Background: Physical inactivity and obesity are major public health problems. Our objective was to investigate the effectiveness of an individual counseling intervention at the workplace on physical activity fitness and health. Counseling content derived from the Patient-centered Assessment and Counseling for Exercise and Nutrition (PACE)...
article 2003
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