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Portengen, L. (author), Preller, L. (author), Tielen, M. (author), Doekes, G. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Background: Recent studies have reported a low prevalence of atopic sensitization and respiratory allergy in children growing up on farms. Objectives: We sought to evaluate the dose-response relationship between endotoxin and atopic sensitization in adult farmers and to assess the effect on respiratory health outcomes. Methods: Data on endotoxin...
article 2005
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Fabriek, B.O. (author), Møller, H.J. (author), Vloet, R.P.M. (author), van Winsen, L.M. (author), Hanemaaijer, R. (author), Teunissen, C.E. (author), Uitdehaag, B.M.J. (author), van den Berg, T.K. (author), Dijkstra, C.D. (author), TNO Kwaliteit van Leven (author)
The scavenger receptor CD163 is selectively expressed on tissue macrophages and human monocytes. CD163 has been implicated to play a role in the clearance of hemoglobin and in the regulation of cytokine production by macrophages. Membrane CD163 can be cleaved by matrix metalloproteinases (MMP) resulting in soluble CD163 (sCD163). In the present...
article 2007
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Barth, P.G. (author), Hirasing, R.A. (author), TNO Preventie en Gezondheid (author)
The prevalence of the severe disease spina bifida is decreasing, but the present rate is still unacceptably high. Only one-third of women planning motherhood use the recommended folic acid, although compliance is increasing. Campaigns for the use of folic acid by these women should be intensified. This method, however, cannot completely prevent...
article 2000
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Fransman, W. (author), Roeleveld, N. (author), Peelen, S. (author), de Kort, W. (author), Kromhout, H. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
BACKGROUND: Nurses and other hospital workers are exposed to antineoplastic drugs during daily activities. Previous studies suggest that antineoplastic drugs at occupational exposure levels may be toxic to reproduction, but these studies are not consistent or conclusive. METHODS: Self-administered questionnaires were completed by 4393 exposed...
article 2007
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Visser, J. (author), Blauw, B. (author), Hinloopen, B. (author), Brommer, E. (author), Ronald De Kloet, E. (author), Kluft, C. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
A disturbed hypothalamus-pituitary-adrenal gland axis and alterations at the immune system level have been observed in patients with chronic fatigue syndrome (CFS). Glucocorticoids are known to modulate T cell responses; therefore, purified CD4 T cells from CFS patients were studied to determine whether they have an altered sensitivity to...
article 1998
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van Noort, J.M. (author), Bsibsi, M. (author), Gerritsen, W.H. (author), van der Valk, P. (author), Bajramovic, J.J. (author), Steinman, L. (author), Amor, S. (author), TNO Kwaliteit van Leven (author)
We present the first comparative analysis of serum immunoglobulinG reactivity profiles against the full spectrum of human myelin-associated proteins in multiple sclerosis patients and healthy control subjects. In both groups, serum antibodies display a consistent and prominent reaction to αB-crystallin (CRYAB) versus other myelin proteins. As an...
article 2010
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Visser, J. (author), Lentjes, E. (author), Haspels, I. (author), Graffelman, W. (author), Blauw, B. (author), de Kloet, R. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
Background: In this study we tested the hypothesis that the increased sensitivity to glucocorticoids in chronic fatigue syndrome (CFS)-patients can be attributed to an altered functioning of their glucocorticoid receptors (GR). Methods: For this purpose, affinity and distribution of the GR were studied in purified, peripheral blood mononuclear...
article 2001
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van Wendel de Joode, B. (author), Vermeulen, R. (author), Heederik, D. (author), van Ginkel, K. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)
We performed an exploratory study to evaluate 2 self-administered questionnaires assessing hand dermatitis and investigate a possible exposure-response relationship between dermal exposure to semi-synthetic metalworking fluids (SMWF) and dermatitis. In a cross-sectional survey on dermatitis, a symptom-based questionnaire and a picture-based skin...
article 2007
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van Strien, T. (author), Herman, C.P. (author), Verheijden, M.W. (author), TNO Kwaliteit van Leven (author)
This study examined which individuals in particular are susceptible or resistant to develop overweight in our current obesogenic environment. A cross-sectional study was conducted in a sample of 1342 people representative of the general population in the Netherlands. Overweight-level (normal body weight ≥ 17.5 BMI [weight in kilograms/height in...
article 2009
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Schuurman, A.G. (author), Goldbohm, R.A. (author), Dorant, E. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In the Netherlands Cohort Study, the authors investigated whether anthropometry is associated with prostate cancer risk. At baseline in 1986, 58,279 men aged 55-69 years completed a self- administered questionnaire on diet, anthropometry, and other risk factors for cancer. After 6.3 years of follow-up, 681 cases were available with complete data...
article 2000
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Proper, K.I. (author), Hildebrandt, V.H. (author), van der Beek, A.J. (author), Twisk, J.W.R. (author), van Mechelen, W. (author)
Background: Physical inactivity and obesity are major public health problems. Our objective was to investigate the effectiveness of an individual counseling intervention at the workplace on physical activity fitness and health. Counseling content derived from the Patient-centered Assessment and Counseling for Exercise and Nutrition (PACE)...
article 2003
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Rosendal, H. (author), Vondeling, H. (author), de Witte, L.P. (author), Hutubessy, R.C.W. (author), van Beekum, W.T. (author), Heine, R.J. (author)
Objective. Assessing whether the initiation of insulin therapy in patients with diabetes mellitus type 2 can be delivered as effectively in a structured transmural care model as in the more usual outpatients structure. Design. Retrospective comparative cohort study. Method. In 1997 data were collected from 52 patients with diabetes mellitus type...
article 2002
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Robitail, S. (author), Simeoni, M.-C. (author), Erhart, M. (author), Ravens-Sieberer, U. (author), Bruil, J. (author), Auquier, P. (author), TNO Preventie en Gezondheid (author)
Purpose: The KIDSCREEN project aims to develop a European cross-cultural generic self-administered Health-Related Quality of Life (HRQoL) instrument for children and adolescents. Proxy measures HRQoL should be a useful and practical alternative to assess children's HRQoL. The KIDSCREEN pilot study involved 3988 children and 2526 child-proxy...
article 2006
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van der Laan, W. (author), Molenaar, E. (author), Ronday, K. (author), Verheijen, J. (author), Breedveld, F. (author), Greenwald, R. (author), Dijkmans, B. (author), Tekoppele, J. (author), Gaubius instituut TNO (author)
Objective. To investigate the effects of doxycycline on disease activity and joint destruction in patients with rheumatoid arthritis (RA). Methods. A 36 week double blind, placebo controlled crossover trial was conducted. Patients (n = 66) received 50 mg doxycycline or placebo twice a day during 12, 24, or 36 weeks. Patient assessments were...
article 2001
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de Looze, M.P. (author), Steenhuizen, S. (author), Boeken-Kruger, M.C. (author), Baten, C.T.M. (author), Kingma, I. (author), van Dieën, J.H. (author)
People who know the actual mass of an object to be lifted normally prepare themselves before attempting a lift to control the movement and to minimize low back loading. In this study, the trunk muscular reactions and low back torque were investigated in the situation in which the individual did not know the actual mass but only had some idea of...
article 2000
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Crone, M.R. (author), Verlaan, M. (author), Willemsen, M.C. (author), van Soelen, P. (author), Reijneveld, S.A. (author), Sing, R.A.H. (author), Paulussen, T.G.W.M. (author), TNO Kwaliteit van Leven (author)
This study assessed the antecedents of continued use of an education program to prevent passive smoking in infants. It consists of a booklet for parents and a manual for health professionals describing a five-step procedure for discussing passive smoking. Aquestionnairewas sent to 67 managers, 670 nurses, and 335 physiciansworking in well-baby...
article 2006
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Tielman, M.L. (author), Neerincx, M.A. (author), van Meggelen, M. (author), Franken, I. (author), Brinkman, W.P. (author)
BACKGROUND AND OBJECTIVE: With the rise of autonomous e-mental health applications, virtual agents can play a major role in improving trustworthiness, therapy outcome and adherence. In these applications, it is important that patients adhere in the sense that they perform the tasks, but also that they adhere to the specific recommendations on...
article 2017
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Kennedy, S. (author), Jin, X. (author), Yu, H. (author), Zhong, S. (author), Magill, P. (author), van Vliet, T. (author), Kistemaker, C. (author), Voors, C. (author), Pasman, W. (author), TNO Kwaliteit van Leven (author)
A proof-of-concept study to assess the safety and efficacy of a traditional Chinese medicine formula as treatment for primary dysmenorrhea showed no statistically significant benefit over placebo. However, some efficacy parameters suggested possible superiority of the active treatment and so a larger study needs to be performed to determine...
article 2006
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van den Heuvel, E.G.H.M. (author), Wils, D. (author), Pasman, W.J. (author), Saniez, M.H. (author), Kardinaal, A.F.M. (author), TNO Kwaliteit van Leven (author)
Background: It is well documented that fermentation of carbohydrates that escape digestion exert several effects supposed to be beneficial for (colonic) health, including an increase in stool volume, a shorter intestinal transit time, production of short chain fatty acids and a decrease of colonic pH (Kritchevsky 1988). NUTRIOSE®FB is a dextrin...
article 2005
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van 't Veer, P. (author), van Leer, E.M. (author), Rietdijk, A. (author), Kok, F.J. (author), Schouten, E.G. (author), Hermus, R.J.J. (author), Sturmans, F. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Combinations of dietary factors were studied in relation to breast-cancer occurrence among 133 breast cancer cases and 289 population controls in The Netherlands. Dietary factors were classified according to their possible mechanism of action, i.e., relating either to the intestinal microflora (total fat, fiber, fermented milk products) or to...
article 1991
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