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de Maat, M.P.M. (author), Kodex, M. (author), Kastelein, J.J.P. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
Elevated plasma fibrinogen levels represent an increased risk for cardiac events. This has enhanced the interest in identifying agents that can normalize elevated plasma fibrinogen levels. Agents that have this capacity are the lipid lowering fibric acid derivatives (e.g. ciprofibrate) and the platelet aggregation inhibitor ticlopidine....
article 1996
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Kastelein, R.A. (author), Steen, N. (author), de Jong, C.A.F. (author), Wensveen, P.J. (author), Verboom, W.C. (author)
Naval sonar systems produce signals which may affect the behavior of harbor porpoises, though their effect may be reduced by ambient noise. To show how natural ambient noise influences the effect of sonar sweeps on porpoises, a porpoise in a pool was exposed to 1-s duration up-sweeps, similar in frequency range (6-7 kHz) to those of existing...
article 2011
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Kastelein, R.A. (author), Huijser, L.A.E. (author), Cornelisse, S. (author), Helder-Hoek, L. (author), Jennings, N. (author), de Jong, C.A.F. (author)
article 2019
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Hoffer, M.J.V. (author), Bredie, S.J.H. (author), Boomsma, D.I. (author), Reymer, P.W.A. (author), Kastelein, J.J.P. (author), de Knijff, P. (author), Demacker, P.N.M. (author), Stalenhoef, A.F.H. (author), Havekes, L.M. (author), Frants, R.R. (author), Gaubius Instituut TNO (author)
Familial combined hyperlipidaemia (FCHL) is one of the major genetic causes of coronary heart disease (CHD) and is characterised by elevated levels of plasma cholesterol and/or triglycerides in individuals within a single family. Decreased lipoprotein lipase (LPL) activity has been found in some cases of FCHL. A recent study revealed a common...
article 1996
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Jennings, N. (author), van der Veen, J. (author), de Haan, D. (author), Kastelein, R.A. (author), van der Heul, S. (author), Verboom, W.C. (author), TNO Defensie en Veiligheid (author)
World-wide, underwater background noise levels are increasing due to anthropogenic activities. Little is known about the effects of anthropogenic noise on marine fish, and information is needed to predict any negative effects. Behavioural startle response thresholds were determined for eight marine fish species, held in a large tank, to tones of...
article 2008
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Kastelein, J. (author), Severs, A.H. (author), Burggraaf, W.N.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1994
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Kastelein, R.A. (author), Hoek, L. (author), Gransier, R. (author), de Jong, C.A.F. (author)
Pile driving is presently the most common method used to attach wind turbines to the sea bed. To assess the impact of pile driving sounds on harbor porpoises, it is important to know at what distance these sounds can be detected. Using a psychophysical technique, a male porpoise’s hearing thresholds were obtained for series of five pile driving...
article 2013
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van Diermen, D.E. (author), Kastelein, J.J.P. (author), Gevers Leuven, J.A. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
The history of the components in oral contraceptives and their effects on lipoprotein metaholism is described in this article. Especially the different progestagens are discussed, and their ability to change the lipidprofile either favourably or unfavourably in regard with the effects on cardiovascular disease. Various possible mechanisms are...
article 1990
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Kastelein, R.A. (author), Helder-Hoek, L. (author), Cornelisse, S.A. (author), von Benda-Beckmann, A.M. (author), Lam, F.P.A. (author), de Jong, C.A.F. (author), Ketten, D.R. (author)
Noise-induced temporary hearing threshold shift (TTS) was studied in a harbor porpoise exposed to impulsive sounds of scaled-down airguns while both stationary and free-swimming for up to 90 min. In a previous study, ∼4 dB TTS was elicited in this porpoise, but despite 8 dB higher single-shot and cumulative exposure levels (up to 199 dB re 1...
article 2020
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Cnossen, H. (author), Kastelein, J. (author), Barendsz, T. (author), TNO Voeding (author)
article 2003
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Kastelein, R.A. (author), Helder-Hoek, L. (author), Gransier, R. (author), Terhune, J.M. (author), Jennings, N. (author), de Jong, C.A.F. (author)
Acoustic mitigation devices (AMDs) are used to deter marine mammals from construction sites to prevent hearing injury by offshore pile-driving noise. In order to quantify the distance at which AMDs designed as ‘seal scarers’ are detected by seals, the 50% hearing thresholds for playbacks of their sounds were determined. The broadband hearing...
article 2015
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Kastelein, R.A. (author), van der Heul, S. (author), Terhune, J.M. (author), Verboom, W.C. (author), Triesscheijn, R.J.V. (author), TNO Defensie en Veiligheid (author)
The marine aquaculture industry suffers losses due to pinniped attacks which damage net enclosures and fish stocks. Acoustic harassment devices (AHDs) emit loud sounds which are intended to deter pinnipeds from approaching aquaculture enclosures. At present, many AHDs emit sounds in the 8-20 kHz frequency range. It is not known whether sounds of...
article 2006
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Agema, W.R.P. (author), de Maat, M.P.M. (author), Zwinderman, A.H. (author), Kastelein, J.J.P. (author), Rabelink, T.J. (author), van Boven, A.J. (author), Feskens, E.J.M. (author), Boer, J.M.A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), Gaubius Instituut TNO (author)
In the present study, we sought to evaluate the role of three polymorphisms in the ecNOS (endothelial constitutive nitric oxide synthase) gene in relation to the existence, severity and progression of CAD (coronary artery disease), MI (myocardial infarction) and the occurrence of ischaemia in a predominantly Caucasian population. Patients with...
article 2004
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Jensen, B.B.B. (author), Cnossen, H. (author), Kastelein, J. (author), Cocker, R. (author), TNO Kwaliteit van Leven (author)
article 2005
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Kastelein, R.A. (author), Steen, N. (author), Gransier, R. (author), Wensveen, P.J. (author), de Jong, C.A.F. (author)
Mid-frequency and low-frequency sonar systems produce frequency-modulated sweeps which may affect harbor porpoises. To study the effect of sweeps on behavioral responses (specifically startle responses, which we define as sudden changes in swimming speed and/or direction), a harbor porpoise in a large pool was exposed to three pairs of sweeps: a...
article 2012
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Henneman, P. (author), van der Sman-de Beer, F. (author), Moghaddam, P.H. (author), Huijts, P. (author), Stalenhoef, A.F.H. (author), Kastelein, J.J.P. (author), van Duijn, C.M. (author), Havekes, L.M. (author), Frants, R.R. (author), van Dijk, K.W. (author), Smelt, A.H.M. (author), TNO Kwaliteit van Leven (author)
Type III hyperlipoproteinemia (HLP) is mainly found in homozygous apolipoprotein (APO) E2 (R158C) carriers. Genetic factors contributing to the expression of type III HLP were investigated in 113 hyper- and 52 normolipidemic E2/2 subjects, by testing for polymorphisms in APOC3, APOA5, HL (hepatic lipase) and LPL (lipoprotein lipase) genes. In...
article 2009
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de Maat, M.P.M. (author), Knipscheer, H.C. (author), Kastelein, J.J.P. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)
An elevated plasma fibrinogen level is increasingly accepted as an independent risk indicator of cardiovascular disease. This has enhanced the interest in identifying agents that can normalize elevated plasma fibrinogen levels. One group of agents with this capacity are the fibric acid derivatives, e. g. ciprofibrate and gemfibrozil. We studied...
article 1997
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de Maat, M.P.M. (author), Kastelein, J.J.P. (author), Jukema, J.W. (author), Zwinderman, A.H. (author), Jansen, H. (author), Groenemeier, B. (author), Bruschke, A.V.G. (author), Kluft, C. (author), Gaubius instituut TNO (author)
Increased plasma fibrinogen levels have been identified as a risk indicator for myocardial infarction, stroke, and thrombosis. Both environmental and genetic factors make an important contribution to plasma fibrinogen levels in humans. In the present study we evaluated, in patients with serum cholesterol levels between 4 and 8 mmol/L, the...
article 1998
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van de Water, H.P.A. (author), Davidse, W. (author), Kastelein, M. (author), Bergsma, E.W. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
article 1992
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Kastelein, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1998
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