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Hiemstra, P. (author), Pasman, K.H.W. (author), van Rijn, M. (author), Willigen, W.H. (author)
Er komt een tijd dat al onze spullen aan het internet hangen en zelf kunnen zien, horen, voelen en meten en zelfs actief taken kunnen uitvoeren. Maar zelfs dan is nog lang niet alles geregeld. Om alle genetwerkte sensorsystemen optimaal te laten samenwerken, onder steeds veranderende omstandigheden en doelen, is er een nieuwe ontwerpbenadering...
article 2013
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van der Does, A.M. (author), Amatngalim, G.D. (author), Keijser, B.J.F. (author), Hiemstra, P.S. (author), Villenave, R. (author)
The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of...
article 2018
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Zarcone, M.C. (author), Duistermaat, E. (author), Alblas, M.J. (author), van Schadewijk, A. (author), Ninaber, D.K. (author), Clarijs, V. (author), Moerman, M.M. (author), Vaessen, D. (author), Hiemstra, P.S. (author), Kooter, I.M. (author)
Harmful effects of diesel emissions can be investigated via exposures of human epithelial cells, but most of previous studies have largely focused on the use of diesel particles or emission sources that are poorly representative of engines used in current traffic. We studied the cellular response of primary bronchial epithelial cells (PBECs) at...
article 2018
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Hiemstra, P.S. (author), Grootaers, G.G. (author), van der Does, A.M. (author), Krul, C.A.M. (author), Kooter, I.M. (author)
The epithelium that covers the conducting airways and alveoli is a primary target for inhaled toxic substances, and therefore a focus in inhalation toxicology. The increasing concern about the use of animal models has stimulated the development of in vitro cell culture models for analysis of the biological effects of inhaled toxicants. However,...
article 2018
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Verberne, S. (author), Sappelli, M. (author), Hiemstra, D. (author), Kraaij, W. (author)
We evaluate five term scoring methods for automatic term extraction on four different types of text collections: personal document collections, news articles, scientific articles and medical discharge summaries. Each collection has its own use case: author profiling, boolean query term suggestion, personalized query suggestion and patient query...
article 2016
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Zarcone, M.C. (author), Duistermaat, E. (author), van Schadewijk, A. (author), Jedynksa, A.D. (author), Hiemstra, P.S. (author), Kooter, I.M. (author)
Cellular response of mucociliary differentiated primary bronchial epithelial cells to diesel exhaust. Am J Physiol Lung Cell Mol Physiol 311: L111–L123, 2016. First published May 17, 2016; doi:10.1152/ajplung.00064.2016.—Diesel emissions are the main source of air pollution in urban areas, and diesel exposure is linked with substantial adverse...
article 2016
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LaCroix, G. (author), Koch, W. (author), Ritter, D. (author), Gutleb, A.C. (author), Larsen, S.T. (author), Loret, T. (author), Zanetti, F. (author), Constant, S. (author), Chortarea, S. (author), Rothen-Rutishauser, B. (author), Hiemstra, P.S. (author), Frejafan, E. (author), Hubert, P. (author), Gribaldo, L. (author), Kearns, P. (author), Aublant, J.M. (author), Diabaté, S. (author), Weiss, C. (author), de Groot, A. (author), Kooter, I.M. (author)
In vitro air–liquid interface (ALI) cell culture models can potentially be used to assess inhalation toxicology endpoints and are usually considered, in terms of relevancy, between classic (i.e., submerged) in vitro models and animal-based models. In some situations that need to be clearly defined, ALI methods may represent a complement or an...
article 2018
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Bos, R. (author), van Leuven, C.J.M. (author), Stolk, J. (author), Hiemstra, P.S. (author), Ronday, H.K. (author), Dijkman, J.H. (author), Nieuwenhuizen, W. (author), TNO Preventie en Gezondheid (author)
In response to inflammatory mediators, polymorphonuclear leukocytes (PMN) are activated and release potent serine proteases, i.e. elastase, cathepsin G and proteinase 3. The aim of this study was to develop an assay to determine PMNmediated fibrinogenolysis in plasma, as a biochemical marker for activated PMN in vivo. On the basis of a special...
article 1996
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Bos, R. (author), van Leuven, C.J.M. (author), Stolk, J. (author), Hiemstra, P.S. (author), Ronday, H.K. (author), Nieuwenhuizen, W. (author), TNO Preventie en Gezondheid (author)
Upon stimulation, polymorphonuclear leucocytes (PMNs) release potent serine proteases, i.e. elastase, cathepsin C and proteinase 3, which contribute to the degradation of tissue and plasma components. Here, we describe the development of a plasma test to assess PMN-mediated fibrinogenolysis as a biochemical marker for actual PMN-derived...
article 1997
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Berbée, J.F.P. (author), Wong, M.C. (author), Wang, Y. (author), van der Hoorn, J.W.A. (author), Khedoe, P.P.S.J. (author), van Klinken, J.B. (author), Mol, I.M. (author), Hiemstra, P.S. (author), Tsikas, D. (author), Romijn, J.A. (author), Havekes, L.M. (author), Princen, H.M.G. (author), Rensen, P.C.N. (author)
Resveratrol is a major constituent of traditional Asian medicinal herbs and red wine and is suggested to be a potential antiatherosclerotic drug due to its proposed hypolipidemic, anti-inflammatory and antioxidative properties. The aim of this study was to evaluate whether resveratrol protects against atherosclerosis development in APOE*. 3...
article 2013
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Zarcone, M.C. (author), van Schadewijk, A. (author), Duistermaat, E. (author), Hiemstra, P.S. (author), Kooter, I.M. (author)
Background: Exacerbations constitute a major cause of morbidity and mortality in patients suffering from chronic obstructive pulmonary disease (COPD). Both bacterial infections, such as those with non-typeable Haemophilus influenzae (NTHi), and exposures to diesel engine emissions are known to contribute to exacerbations in COPD patients....
article 2017
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Berbeé, J.F.P. (author), Boon, M.R. (author), Khedoe, P.P.S.J. (author), Bartelt, A. (author), Schlein, C. (author), Worthmann, A. (author), Kooijman, S. (author), Hoeke, G. (author), Mol, I.M. (author), John, C. (author), Jung, C. (author), Vazirpanah, N. (author), Brouwers, L.P.J. (author), Gordts, P.L.S.M. (author), Esko, J.D. (author), Hiemstra, P.S. (author), Havekes, L.M. (author), Scheja, L. (author), Heeren, J. (author), Rensen, P.C.N. (author)
Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma triglyceride levels and reducing obesity. However, the precise role of BAT in plasma cholesterol metabolism and atherosclerosis development remains unclear. Here we show that BAT activation by b3-adrenergic receptor stimulation protects from atherosclerosis...
article 2015
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Wong, M.C. (author), van Diepen, J.A. (author), Hu, L. (author), Guigas, B. (author), de Boer, H.C. (author), van Puijvelde, G.H. (author), Kuiper, J. (author), van Zonneveld, A.J. (author), Shoelson, S.E. (author), Voshol, P.J. (author), Romijn, J.A. (author), Havekes, L.M. (author), Tamsma, J.T. (author), Rensen, P.C.N. (author), Hiemstra, P.S. (author), Berbée, J.F.P. (author)
Objective: The liver is the key organ involved in systemic inflammation, but the relation between hepatic inflammation and atherogenesis is poorly understood. Since nuclear factor-κB (NF-κB) is a central regulator of inflammatory processes, we hypothesized that chronically enhanced hepatic NF-κB activation, through hepatocyte-specific expression...
article 2012
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Khedoe, P.P.S.J. (author), Wong, M.C. (author), Wagenaar, G.T.M. (author), Plomp, J.J. (author), van Eck, M. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), Hiemstra, P.S. (author), Berbée, J.F.P. (author)
Background: Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary inflammation, airways obstruction and emphysema, and is a risk factor for cardiovascular disease (CVD). However, the contribution of these individual COPD components to this increased risk is unknown. Therefore, the aim of this study was to determine the...
article 2013
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de Jong, T. (author), Hiemstra, S. (author)
Deze goede praktijk is een initiatief van TNO, Stigas en Ministerie van Sociale Zaken en Werkgelegenheid.
book 2013
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Hiemstra, D. (author), Kraaij, W. (author), TNO Informatie- en Communicatietechnologie (author)
In this paper we present the language modeling approach to information retrieval as a toolbox to systematically combine information from different sources. Four TREC subtasks (Ad Hoc, Entry Page, Adaptive Filtering and Cross-language) are used to illustrate the application of language models to different information retrieval problems.
bookPart 2005
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Hiemstra, D. (author), Kraaij, W. (author), Pohlmann, R. (author), Westerveld, T. (author), Technisch Physische Dienst TNO - TH (author)
This paper describes the official runs of the Twenty-One group for the first CLEF workshop. The Twenty-One group participated in the monolingual, bilingual and multilingual tasks. The following new techniques are introduced in this paper. In the bilingual task we experimented with different methods to estimate translation probabilities. In the...
conference paper 2001
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Trieschnigg, D. (author), Hiemstra, D. (author), de Jong, F. (author), Kraaij, W. (author), TNO Informatie- en communicatietechnologie (author)
An important challenge for biomedical information retrieval (IR) is dealing with the complex, inconsistent and ambiguous biomedical terminology. Frequently, a concept-based representation defined in terms of a domain-specific terminological resource is employed to deal with this challenge. In this paper, we approach the incorporation of a...
conference paper 2010
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Hiemstra, P. (author), Benoist, K.W. (author), van den Broek, S.P. (author), van Iersel, M. (author), Kester, L.J.H.M. (author), Bergmans, J. (author), TNO Defensie en Veiligheid (author)
conference paper 2008
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Schutte, K. (author), Bomhof, F.W. (author), Burghouts, G.J. (author), van Diggelen, J. (author), Hiemstra, P. (author), van 't Hof, J. (author), Kraaij, W. (author), Pasman, K.H.W. (author), Smith, A.J.E. (author), Versloot, C.A. (author), de Wit, J.J. (author)
More and more sensors are getting Internet connected. Examples are cameras on cell phones, CCTV cameras for traffic control as well as dedicated security and defense sensor systems. Due to the steadily increasing data volume, human exploitation of all this sensor data is impossible for effective mission execution. Smart access to all sensor data...
conference paper 2013
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