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Bank, R.A. (author), Krikken, M. (author), Beekman, B. (author), Stoop, R. (author), Maroudas, A. (author), Lafeber, F.P.J.G. (author), TeKoppele, J.M. (author)
article 1997
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Vlasveld, M.C. (author), van der Feltz-Cornelis, C.M. (author), Bültmann, U. (author), Beekman, A.T.F. (author), van Mechelen, W. (author), Hoedeman, R. (author), Anema, J.R. (author)
article 2012
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Bank, R.A. (author), Jansen, E.J. (author), Beekman, B. (author), te Koppele, J.M. (author), Gaubius Instituut TNO (author)
article 1996
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van Wees, J.D. (author), van Bergen, F. (author), David, P. (author), Nepveu, M. (author), Beekman, F. (author), Cloetingh, S. (author), Bonté, D. (author), TNO Bouw en Ondergrond (author)
Tectonic modeling is often neglected in the basin modeling workflow and heat flow is most times considered a user input. Such heat flows can, therefore, result in erroneous basin modeling outcomes, resulting in false overoptimistic identification of prospective areas or failure to identify prospects. This is particularly true for areas with...
article 2009
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Beekman, M. (author), Heijmans, B.T. (author), Martin, N.G. (author), Whitfield, J.B. (author), Pedersen, N.L. (author), de Faire, U. (author), Snieder, H. (author), Lakenberg, N. (author), Suchiman, H.E.D. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Boomsma, D.I. (author), Slagboom, P.E. (author)
The genetic basis of cardiovascular disease (CVD) with its complex etiology is still largely elusive. Plasma levels of lipids and apolipoproteins are among the major quantitative risk factors for CVD and are well-established intermediate traits that may be more accessible to genetic dissection than clinical CVD end points. Chromosome 19 harbors...
article 2003
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Beekman, M. (author), Heijmans, B.T. (author), Martin, N.G. (author), Whitfield, J.B. (author), Pedersen, N.L. (author), de Faire, U. (author), Snieder, H. (author), Lakenberg, N. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Slagboom, P.E. (author), Boomsma, D.I. (author)
Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a...
article 2003
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Beekman, B. (author), Drijfhout, J.W. (author), Ronday, H.K. (author), TeKoppele, J.M. (author), Gaubius instituut TNO (author)
Elevated MMP activities are implicated in tissue degradation in, e.g., arthritis and cancer. The present study was designed to measure MMP enzyme activity in plasma. Free active MMP is unlikely to be present in plasma: upon entering the circulation, active MMP is expected to be captured by the proteinase inhibitor α2-macroglobulin (α2M)....
article 1999
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van Valburg, A.A. (author), Wenting, M.J.G. (author), Beekman, B. (author), TeKoppele, J.M. (author), Lafeber, F.P.G.J. (author), Bijlsma, J.W.J. (author)
article 1997
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Beekman, B. (author), Verzijl, N. (author), Bank, R.A. (author), Von Der Mark, K. (author), TeKoppele, J.M. (author), TNO Preventie en Gezondheid (author)
The extracellular matrix synthesized by articular chondrocytes cultured in alginate beads was investigated. Collagen levels increased sigmoidally with time and remained constant after 2 weeks of culture. The presence of cartilage-specific type II collagen was confirmed immunohistochemically. Predominantly type H collagen was present in the...
article 1997
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Guigas, B. (author), de Leeuw van Weenen, J.E. (author), van Leeuwen, N. (author), Simonis-Bik, A.M. (author), van Haeften, T.W. (author), Nijpels, G. (author), Houwing-Duistermaat, J.J. (author), Beekman, M. (author), Deelen, J. (author), Havekes, L.M. (author), Penninx, B.W.J.H. (author), Vogelzangs, N. (author), van 't Riet, E. (author), Dehghan, A. (author), Hofman, A. (author), Witteman, J.C. (author), Uitterlinden, A.G. (author), Grarup, N. (author), Jørgensen, T. (author), Witte, D.R. (author), Lauritzen, T. (author), Hansen, T. (author), Pedersen, O. (author), Hottenga, J. (author), Romijn, J.A. (author), Diamant, M. (author), Kramer, M.H.H. (author), Heine, R.J. (author), Willemsen, G. (author), Dekker, J.M. (author), Eekhoff, E.M. (author), Pijl, H. (author), de Geus, E.J. (author), Slagboom, P.E. (author), 't Hart, L.M. (author)
Aims: Modulation of dopamine receptor D2 (DRD2) activity affects insulin secretion in both rodents and isolated pancreatic β-cells. We hypothesized that single nucleotide polymorphisms in the DRD2/ANKK1 locus may affect susceptibility to Type 2 diabetes in humans. Methods: Four potentially functional variants in the coding region of the DRD2...
article 2014
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Bank, R.A. (author), Beekman, B. (author), Tenni, R. (author), Tekoppele, J.M. (author), Gaubius Instituut TNO (author)
Measurement of the glycosylated hydroxylysines galactosyl- and glucosylgalactosylhydroxylysine (GH and GGH) in combination with other amino acids has been based on ion-exchange chromatography followed by reaction with ninhydrin. Here, a rapid and sensitive high-performance liquid chromatographic method with fluorimetric detection has been...
article 1997
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Beekman, M. (author), Posthuma, D. (author), Heijmans, B.T. (author), Lakenberg, N. (author), Suchiman, H.E.D. (author), Snieder, H. (author), de Knijff, P. (author), Frants, R.R. (author), van Ommen, G.J.B. (author), Kluft, C. (author), Vogler, G.P. (author), Slagboom, P.E. (author), Boomsma, D.I. (author)
Combined association and linkage analysis is a powerful tool for pinpointing functional quantitative traits (QTLs) responsible for regions of significant linkage identified in genome-wide scans. We applied this technique to apoE plasma levels and the APOEε2/ε3/ε4 polymorphism in two Dutch twin cohorts of different age ranges. Across chromosome...
article 2004
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Beekman, B. (author), van El, B. (author), Drijfhout, J.W. (author), TeKoppele, J.M. (author)
article 1999
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te Koppele, J.M. (author), Beekman, B. (author), Bloemhoff, W. (author), Drijfhout, J.W. (author), TNO Preventie en Gezondheid (author)
article 1995
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Cloetingh, S. (author), Cornu, T. (author), Ziegler, P.A. (author), Beekman, F. (author), Ustaszewski, K. (author), Schmid, S.M. (author), Dèzes, P. (author), Hinsch, R. (author), Decker, K. (author), Lopes Gardozo, G. (author), Granet, M. (author), Bertrand, G. (author), Behrmann, J. (author), van Balen, R. (author), Michon, L. (author), Pagnier, H. (author), Rozsa, S. (author), Heck, B. (author), Tesauro, M. (author), Kahle, H.G. (author), Dewez, T. (author), Carretier, S. (author), Winter, T. (author), Hardebol, N. (author), Bada, G. (author), Dost, B. (author), van Eck, T. (author), TNO Bouw en Ondergrond (author)
Research on neotectonics and related seismicity has hitherto been mostly focused on active plate boundaries that are characterized by generally high levels of earthquake activity. Current seismic hazard estimates for intraplate domains are mainly based on probabilistic analyses of historical and instrumental earthquake catalogues. The accuracy...
article 2006
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Bank, R.A. (author), Beekman, B. (author), Verzijl, N. (author), de Roos, J.A.D.M. (author), Nico Sakkee, A. (author), Tekoppele, J.M. (author), TNO Preventie en Gezondheid (author)
A high-performance liquid chromatographic assay was developed for pyridinium crosslinks and pentosidine in mature collagen of a wide variety of connective tissue hydrolysates by a simple two-step isocratic assay using a reversed-phase column. The crosslinks (including the internal standard pyridoxine) were optimally detected by their native...
article 1997
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Sagastizabal, R. (author), Bonet-Monroig, X. (author), Singh, M. (author), Rol, M.A. (author), Bultink, C.C. (author), Fu, X. (author), Price, C.H. (author), Ostroukh, V.P. (author), Muthusubramanian, N. (author), Bruno, A. (author), Beekman, M. (author), Haider, N. (author), O'Brien, T.E. (author), Dicarlo, L. (author)
article 2019
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Cloetingh, S. (author), van Wees, J.D. (author), Ziegler, P.A. (author), Lenkey, L. (author), Beekman, F. (author), Tesauro, M. (author), Förster, A. (author), Norden, B. (author), Kaban, M. (author), Hardebol, N. (author), Bonté, D. (author), Genter, A. (author), Guillou-Frottier, L. (author), ter Voorde, M. (author), Sokoutis, D. (author), Willingshofer, E. (author), Cornu, T. (author), Worum, G. (author), TNO Bouw en Ondergrond (author)
Knowledge of temperature at drillable depth is a prerequisite in site selection for geothermal exploration and development of enhanced geothermal systems (EGS). Equally important, the thermo-mechanical signature of the lithosphere and crust provides critical constraints for the crustal stress field and basement temperatures where borehole...
article 2010
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TeKoppele, J.M. (author), Beekman, B. (author), Verzijl, N. (author), Koopman, J.L. (author), de Groot, J. (author), Bank, R.A. (author), Gaubius Instituut TNO (author)
Doxycycline (DOX) profoundly inhibited collagen synthesis by differentiated articular chondrocytes. At 25 microM, the rate of collagen synthesis was suppressed by more than 50% without affecting cell proliferation (DNA levels) and general protein synthesis (35S-Met and 35S-Cys incorporation). Steady-state mRNA levels of type II collagen were...
article 1998
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Beekman, B. (author), Verzijl, N. (author), de Roos, J.A.D.M. (author), TeKoppele, J.M. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
Objective: To determine the role of interleukin-1β (IL-1β) in the degradation of proteoglycans and collagen by articular chondrocytes. Design: Chondrocytes were cultured in alginate beads for 2 weeks to produce extracellular matrix, followed by the addition of IL-1β for 1 or 2 days. Breakdown of extracellular matrix (with and without activation...
article 1998
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