Effects of alkali treated proteins: Feeding studies with free and protein bound lysinoalanine in rats and other animals

To find out whether alkali treated proteins possess nephrotoxic properties, feeding studies were conducted with drastically treated soybean protein and casein, and also with lysinoalanine (LAL), the amino acid known to be formed in proteins subjected to high pH at an elevated temperature. The feeding of synthesized LAL to rats at dietary levels...

Protein metabolism in the rat cerebral cortex in vivo and in vitro as affected by the acquisition enhancing drug piracetam

The effect of Piracetam on rat cerebral protein metabolism in vivo and in vitro was studied. It was found that the drug stimulates the uptake of labelled leucine by cerebral cortex slices, has no effect on the incorporation of leucine into cerebral protein, neither in slices nor in vivo, but inhibits the breakdown of newly formed protein in...

Radiosensitization of mammalian cells by diamide

The effect of diamide on the radiosensitivity of T cells was investigated under oxic and anoxic conditions. The compound was found to sensitize the cells under both conditions. Under oxic conditions, exposure for 10 min before and during irradiation to 0.1, 0.5 and 1.0 mM diamide produced dose modifying factors of 0.81, 0.60 and 0.55,...

The effect of ACTH analogues on motor behavior and visual evoked responses in rats

Averaged visual evoked responses (VER) in cortical area 17 were recorded one hour after the administration of 7-l-phe ACTH(4-10) or 7-d-phe ACTH(4-10) to artificially ventilated rats, paralysed with gallamine. In addition, the effects of these peptides on spontaneous motor behavior were analyzed. The results show that the latencies of all VER...

Enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection

In studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. In contrast the application of cytostatic drugs and...

Zitproblemen en de "vacuum-vormfixatie" (Sitting problems and the vacuum form fixation)

The merits of the 'vacuum form fixation' are discussed for the production of reliable body impressions of patients suffering from sitting problems. Impressions are taken with the patients seated in the desired posture. The first results are reported, obtained from 4 patients of different categories, fitted with individually moulded seats...

Nutritional effects of alkali treated soyprotein in rats

Alkali treated spun soy isolate was fed to rats at dietary levels of 5, 10, and 20% for a period of 90 days. The results failed to reveal any adverse effects on general appearance, growth, feeding efficiency, hematological indices, blood serum values, urine composition, kidney function, organ weights, and gross and microscopic pathology except...

Intra arterial infusion with methotrexate in the rat

Chemicals/CAS: folinate calcium, 1492-18-8, 51057-63-7; folinic acid, 58-05-9, 68538-85-2; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; Leucovorin, 58-05-9; Methotrexate, 59-05-2

The aetiology of caecal enlargement in the rat

The effect of hydroxypropyl starches (degree of substitution (DS) 0.025-0.106), lactose, raw potato starch, polyethylene glycol 1000 or magnesium sulphate on caecal size and some constituents of the caecal contents was studied in male rats of ages varying from 4 wk to 3 mth in experiments lasting from 10 days to 3 mth. All the test compounds...

Changes of lymphocyte kinetics in the normal rat, induced by the lymphocyte mobilizing agent polymethacrylic acid

The changes in lymphocyte kinetics induced by the lymphocyte mobilizing agent polymethacrylic acid (PMAA) were studied in the normal rat. Quantitative data are presented concerning the degree of lymphocyte mobilization in the spleen and in various lymph nodes at different times after PMAA administration. Data were also obtained regarding the...

Naturally occurring endocardial disease in the rat

Factors determining cell killing by chemotherapeutic agents In Vivo-II: Melphalan, chlorambucil and nitrogen mustard

The sensitivity of resting spleen colony-forming cells in normal mouse bone marrow and of rapidly-proliferating spleen colony-forming cells in repopulating mouse spleen to a number of bis-chloro-aethyl-amines was determined. The rapidly-growing cells were more sensitive to each of the agents than the resting cells. The equal degree of...

Early increase of amino acid transport in stimulated lymphocytes

Chemicals/CAS: 2 amino 2 methylpropionic acid, 62-57-7; carbon, 7440-44-0; thymidine, 50-89-5; tritium, 10028-17-8; Aminoisobutyric Acids; Carbon Isotopes; Lectins; Thymidine, 50-89-5; Tritium, 10028-17-8

Toxicologic and pharmacologic properties of iocetamic acid, a new oral cholecystographic agent

Studies in rats on iocetamic acid show that the LD50 levels of this compound compare favorably with those of a number of other oral cholecystographic agents. Pathologic effects are not found in rats and cats in studies of the subacute toxicity. Incompatibility with an anesthetic or a tranquilizer is not found. The elimination pattern of...

Toxicologic studies of iocetamic acid in rats and dogs

A new oral cholecystographic medium called iocetamicacid was submitted to a toxicologic study in rats and dogs. Dosages, which were equivalent to 200 and 1000 mg of the compound per kilogram of body weight per day and were 5 times and 25 times the human routine dose, were administered daily for 3 weeks in order to establish whether the substance...

The regulation of cell proliferation and differentiation in intestinal epithelium. II. A quantitative histochemical and autoradiographic study after low doses of X-irradiation

To investigate the biochemical mechanisms involved in the regulation of cell proliferation and differentiation the intestinal epithelium has been chosen because of the regular distribution of proliferative-, non-dividing maturing- and functional cells along the crypt and villus. The effect of low doses of irradiation (50-400 R) which selectively...

Cartilaginous focus at the base of the non-coronary semilunar valve of the aorta in rats of different ages

Cartilaginous tissue in the heart of rat has been described in literature by some as an ageing phenomenon, while others have observed it in young animals. Hearts of rats of different ages were studied for the occurence and localization of cartilaginous tissue. A cartilaginous focus has been regularly found in rats as young as 1 week old. This...

Maximum oxygen uptake in healthy nonathletic males

Maximum oxygen uptake ( {Mathematical expression} max), maximum heart rate (MHR), blood lactic acid (LA) and pH were measured during bicycle ergometer exercise in 52 men, 22 to 60 years old, engaged in clerical and light manual work (prison personnel and prisoners in the Netherlands). {Mathematical expression} max decreases with, age, but less...