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Vos, J.J. (author), Walraven, P.L. (author), Instituut voor Zintuigfysiologie TNO (author)
To derive the fundamental response curves for the three colour mediating systems from the location of the dichromatic confusion centres, one must make certain assumptions on the nature of dichromatism. It is shown, however, that one can avoid to make specific quantitative assumptions by bringing into the picture other visual data, such as the...
article 1971
document
Medisch Biologisch Labortorium TNO (author), Kleijer, W.J. (author), Lohman, P.H.M. (author), Mulder, M.P. (author), Bootsma, D. (author)
Repair replication and rejoining of single-strand breaks after X-irradiation in human-skin fibroblasts from normal donors and several patients with xeroderma pigmentosum have been compared. The xeroderma strains showed different levels of repair replication following UV exposure. Repair replication and rejoining of breaks, which are considered...
article 1970
document
Centraal Instituut voor Voedingsonderzoek TNO (author), Janbroers, J.M. (author), Sanders, J.C. (author), Til, H.P. (author), Feron, V.J. (author), de Groot, A.P. (author)
Studies in rats on iocetamic acid show that the LD50 levels of this compound compare favorably with those of a number of other oral cholecystographic agents. Pathologic effects are not found in rats and cats in studies of the subacute toxicity. Incompatibility with an anesthetic or a tranquilizer is not found. The elimination pattern of...
article 1969
document
Bleichrodt, J.F. (author), van Abkoude, E.R. (author), Medisch Biologisch Laboratorium TNO (author)
If cells of the bacterium Escherichia coliC infected with bacteriophage φX174 are lysed artificially in the cold, the phage obtained is relatively heat resistant at temperatures around 65° and unable to adsorb to host cells at 4°. At 37° the phage particles become more thermolabile with respect to inactivation at 65° and, concomitantly, obtain...
article 1967
document
Walraven, P.L. (author), Instituut voor Zintuigfysiologie TNO (author)
THE Stiles–Crawford effect1,2, or the dependence of luminous efficiency on the eccentricity of the point of entry of the light in the pupil, is a function of the wavelength of the light. In Fig. 1 is given the inverse 1/ of the luminous efficiency as a function of wave-length at a distance of 3.5 mm from the point of maximum efficiency,...
article 1966
document
Medisch Biologisch Labortorium TNO (author), Galavazi, G. (author), Bootsma, D. (author)
Some aspects of the population dynamics before, during and after the double thymidine treatment synchronization procedure were analysed. The mitotic index in the synchronized populations rose from 0.0 per cent at 1 hr after the end of the second treatment to 20.8 per cent at 9.7 hr, dropped to 0.1 per cent at about 22 hr and increased again to a...
article 1966
document
Medisch Biologisch Labortorium TNO (author), Galavazi, G. (author), Schenk, H. (author), Bootsma, D. (author)
An optimal procedure to synchronize the life cycles of the individuals in a population of human cells, cultured in vitro, by repeated temporary inhibition of the DNA synthesis was elaborated. Cultures in the logarithmic growth phase were treated three times with 7.5 mM thymidine dissolved in medium. Each treatment was terminated after 24 hr by...
article 1966
document
Böttcher, C.J.F. (author), Klynstra, F.B. (author)
article 1963
document
de Haas, J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
article 1960
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de Haas, J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
An orientation of modern child care viewed in the light of the trend in Scandinavia and the Netherlands places the following concepts before us. Now that infant mortality has reached a level of twenty per thousand births, we have arrived at an important point in the development of child care. This fact forces us not only to form an impression of...
article 1958
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de Haas, J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)
The comparison between pediatrics in East and West and in neighbouring countries is called geographical pediatrics, iqaccordance with the term Geographical Pathology. Difference in place is actually rather a difference in time. Inevitably the study of child life in the tropics is still based on Western principles. Medical thinking based on...
article 1954
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Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author), de Haas, J.H. (author)
Bij de oprichting van de Gezondheidsorganisatie c'.N.O. in 1950 bestond in ons land de paradox van relatief goede resultaten op sociaal-hygienisch ge­bied en een beperkte wetenschappelijke basis van de sociale hygiene. Het is de taak van de Gezond­heidsorganisatie T.N.O .. deze basis te verbreden. Bij uitvoering van de onderzoekingen en...
article 1954
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