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Burgers, J.S. (author), Fleuren, M.A.H. (author), Lugtenberg, M. (author), Hulshof, C.T.J. (author)
Het is van belang te evalueren of een richtlijn daadwerkelijk wordt gebruikt en na te gaan of de beoogde effecten voor patiënten worden gerealiseerd. Bij de evaluatie is het zinvol ook naar determinanten van het gebruik te kijken, zodat interventies gericht kunnen worden ingezet om de toepassing te verbeteren. Zowel kwantitatieve als...
bookPart 2014
document
J. van der Wees, P. (author), Kamphuis, M. (author), Borgonjen, R.J. (author)
Bij de samenstelling van richtlijnwerkgroepen wordt gezocht naar een goede menging van ervaring en wetenschappelijk inzicht met betrekking tot het bewuste onderwerp. In de samenstelling van een werkgroep streeft men naar evenredige vertegenwoordiging van alle betrokken verenigingen en instanties. Speciale aandacht verdient de keuze van de...
bookPart 2014
document
Peters, P. (author), Kraan, K. (author), van Echtelt, P. (author)
We brengen in kaart wat de relatie is tussen Het Nieuwe Werken en emotionele uitputting. Voor dit onderdeel is samengewerkt met de Radboud Universiteit Nijmegen en TNO. De resultaten van deze twee analyses zijn deels eerder gepubliceerd in een themanummer van het Tijdschrift voor Arbeidsvraagstukken (2013, nr. 3).
bookPart 2014
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Stierum, R.H. (author)
This introduction outlines the need for tools and approaches for toxicogenomics data storage and interpretation needed towards development of alternatives to animal testing. Systems toxicology databases will be discussed in Chapter 6.2. Bioinformatics approaches, in particular text-mining, will be explained in Chapter 6.3. © 2014 Elsevier Inc....
bookPart 2014
document
Kleinknecht, A. (author), Naastepad, C.W.M. (author), Storm, S. (author), Vergeer, R. (author)
bookPart 2013
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Kuper, C.F. (author), Ruehl-Fehlert, C. (author), Elmore, S.A. (author), Parker, G.A. (author)
Cells of the immune system are found in every organ, from the classic lymphoid organs to tissues such as liver, mucosae, and omental adipose tissue. Toxicity to the immune system may be from a direct or indirect injury to lymphoid organs. The morphological responses range from lymphocyte depletion to proliferation, and may result in an increased...
bookPart 2013
document
Crevel, R.W.R. (author), Ballmer-Weber, B.K. (author), Taylor, S.L. (author), Houben, G.F. (author), Mills, C. (author)
Thresholds for allergenic foods constitute a key element in characterizing the hazard and assessing the risk to allergic consumers from those foods. Threshold determination for key allergenic foods in Europe was identified as a major element and deliverable in the EuroPrevall work program. The value of this work was based on the twin foundations...
bookPart 2013
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Madsen, C.B. (author), Houben, G. (author), Hattersley, S. (author), Crevel, R.W.R. (author), Remington, B.C. (author), Baumert, J.L. (author)
Regulatory thresholds for allergenic foods have not yet been developed. This means that public and industrial risk managers do not have regulatory thresholds to decide if a content or level of contamination is acceptable or not. For a long time, data have been inadequate to define safe thresholds for food allergens. More and more challenge data...
bookPart 2013
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Nelis, A. (author), Detmar, S. (author), van den Akker, E. (author)
Fictional portrayals of our possible future, such as the Hollywood film Gattaca, often conceive of a world where the genetic profile of each individual determines opportunity. Parents select the best sets of genes for their children to make sure they will be as successful, smart and healthy as possible. To what extent is such a scenario credible...
bookPart 2013
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Maas, J. (author), Sterkenburg, R.P. (author), de Vries, S.I. (author), Pierik, F. (author)
There has been an increasing focus on examining the relationship between neigh-bourhood built environment and health and health behaviours. This is mainly due to the potential of environmental interventions for having a sustained impact on entire population groups rather than a short-term impact on individuals (Giles-Corti et al. 2005). Moreover...
bookPart 2013
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Brouwer, D.H. (author)
bookPart 2013
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van Ginneken, V.J.T. (author), Verheij, E. (author), Hekman, M. (author), van der Greef, J. (author), Feskens, E.J.M. (author), Poelmann, R.E. (author)
We investigated with LC-MS techniques, measuring approximately 109 lipid compounds, in mouse brain and liver tissue after 48 hours of starvation and a High-Fat Diet if brain and liver lipid composition changed. We measured Cholesterolesters (ChE), Lysophosphatidyl-cholines (LPC), Phosphatidylcholine (PC), Sphingomyelin (SPM) and Triacylglycerols...
bookPart 2011
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Notermans, S. (author), Powell, S.C. (author), Hoornstra, E. (author), TNO Kwaliteit van Leven (author)
bookPart 2005
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