Association between beta-carotene and acute myocardial infarction depends on polyunsaturated fatty acid status: The EURAMIC study

Because antioxidants may play a role in the prevention of coronary heart disease by inhibiting the peroxidation of polyunsaturated fatty acids (PUFAs), the combined association of diet-derived antioxidants and PUFAs with acute myocardial infarction (MI) was investigated. This multicenter case- control study included 674 patients and 725 control...

Short-term moderate energy restriction does not affect indicators of oxidative stress and genotoxicity in humans

Restriction of energy intake (ER), without malnutrition of essential nutrients, has repeatedly been demonstrated to increase longevity in rodents. In the antioxidant theory of aging the lack of balance between the generation of free radicals and free radical scavenging was thought to be a main causal agent in the aging process. From this point...

Hepatocellular localisation of biosynthesis of vitronectin. Characterisation of the primary structure of rat vitronectin

To characterize the primary structure of rat Vn, a cDNA library constructed from freshly isolated rat hepatocytes, was screened with a human Vn cDNA probe. Comparison of the sequence of the obtained rat cDNA clone with the sequences of human, mouse and rabbit Vn cDNA's showed predominantly consensus in the somatomedin B domain, the RGD-sequence...

Resultaten van jeugdtandverzorging: een onderzoek naar mondgezondheid en mondhygiënisch gedrag bij deelnemers aan Regionale Instellingen [Results of youth dentistry: oral health and oral hygiene habits of children participating in regional institutions]

In order to evaluate the results of Regional Institutions (RI's) for Youth Dentistry, an epidemiological study was performed on caries experience and oral hygiene habits of 5-, 8- and 11-year-olds, getting dental treatment in these institutions. In the big cities participants of the RI's appeared to be mostly from the lower social levels of...

The effects of 4-aminopyridine on cognitive function in patients with multiple sclerose: A pilot study

4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could...

Decreased sensitivity to dexamethasone in lymphocytes from patients with Alzheimer's disease

Cortisol levels in patients with Alzheimer's disease (AD) are relatively unaffected by a challenge with dexamethasone (DEX) in vivo. The present study demonstrates that DEX is less inhibitory for phytohemagglutinin (PHA)-induced T cell proliferation in AD patients as compared to age-matched controls. Since no significant differences were found...

Tandcariës bij kinderen uit etnische groepen in Nederland: een overzicht vn de literatuur [Dental caries in children from ethnic groups in the Netherlands: a literature review]

This article reviews the literature on child dental caries in various ethnic groups in the Netherlands. Material from fifteen studies showed generally the dental health of five- to eleven-year-old children of parents born in Turkey or Morocco to be far worse than that of children of Dutch or Surinamese parents. The ethnic groups distinguished,...

Cariës bij kinderen uit etnische groepen: een onderzoek bij vijfjarige Amsterdamse kinderen en hun ouders naar risico-indicatoren en -factoren [Caries in children from ethnic groups: an investigation in five-year-old children in Amsterdam and their parents concerning risk indicators and factors]

A previous study has shown five-year-old children of parents originating from Turkey or Morocco to have twice as much dmfs as children of parents from The Netherlands, Surinam or various other countries. In the present study, other risk indicators and factors for the prevalence of caries amongst these children were studied by interviewing their...

Voedingsgewoonten van Turkse en Marokkaanse kinderen in Nederland [Dietary habits of Turkish and Moroccan children in the Netherlands]

Migration might have considerable implications for nutrition and consequently for health. Because of the higher demands of growth, children are especially vulnerable to changes in nutrition. In order to get an insight into the need for a special nutrition policy for Turkish ad Moroccan children, the dietary habits and food consumption of 8-year...

Etniciteit en het Besluit TJZ [Ethnicity and the TJZ decision]

The aim of this study was to assess differences in oral health and dental behaviour in a cohort of five-year-old children born in 1982 and a cohort of eleven-year-old children born in 1976, in different ethnic and socio-economic groups, in the period from 1987 to 1990. To this end a secondary analysis was performed on data collected in a study...

Tandheelkunde in Turkije en Marokko [Dentistry in Turkey and Morocco]

Some information is given on the number of dentists in Turkey and Morocco and the dental condition of the inhabitants. This information concerns prevention, caries, periodontic diseases as well as other dental diseases and diseases of the mouth.

Hereditary cerebral hemorrhage with amyloidosis - Dutch type: A study of fibrinolysis

In view of reported associations between increased bleeding tendency and systemically decreased alpha 2-antiplasmin in patients with systemic amyloid deposition we studied alpha 2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with...

In vivo and in vitro interaction of high and low molecular weight single-chain urokinase-type plasminogen activator with rat liver cells

The plasma clearance and the interaction of high (HMW) and low (LMW) molecular weight single-chain urokinase-type plasminogen activator (scu-PA) with rat liver cells was determined. 125I-Labeled HMW- and LMW-scu-PA were rapidly cleared from plasma with a half-life of 0.45 min and a maximal liver uptake of 55% of the injected dose. Liver uptake...

Forearm arterial pressure-volume relationships in man

Pressure-volume (p-V) relationships of a segment of the forearm circulation have been measured in nine male healthy subjects. Forearm volume was measured using electrical impedance plethysmography, arterial transmural pressure by subtracting mean arterial pressure measured contralaterally in a finger from the pressure in a cuff placed over the...