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Hau, M.-F. (author), Smelt, A.H.M. (author), Bindels, A.J.G.H. (author), Sijbrands, E.J.G. (author), van der Laarse, A. (author), Onkenhout, W. (author), van Duyvenvoorde, W. (author), Princen, H.M.G. (author), Gaubius Instituut TNO (author)
In hypertriglyceridemic (HTG) patients the addition of fish oil to the diet causes a marked reduction in the concentration of triglyceride-rich lipoproteins in the serum. To investigate the effects of fish oil on the oxidation resistance of VLDL and LDL in HTG patients, nine male patients received 1 g/d fish oil (containing 55.7% n-3...
article 1996
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Groen, E. (author), de Graaf, B. (author), Bles, W. (author), Bos, J.E. (author), TNO Technische Menskunde (author)
To assess a possible otolith contribution to effects observed following prolonged expo-sure to hyper gravity, we used video-oculography to measure ocular torsion during static and dynamic conditions of lateral body tilt (roll) before and after one hour of centrifugation with a Gx-load of 3G. Static tilt (from 0 to 57 deg. to either side) showed...
article 1996
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Rompelberg, C.J.M. (author), Ploemen, J.H.T.M. (author), Jespersen, S. (author), van der Greef, J. (author), Verhagen, H. (author), van Bladeren, P.J. (author), TNO Voeding (author)
The irreversible and reversible inhibition of glutathione S-transferases (GSTs) by eugenol was studied in rat, mouse and man. Using liver cytosol of human, rat and mouse, species differences were found in the rate of irreversible inhibition of GSTs by eugenol in the presence of the enzyme tyrosinase. Tyrosinase was used to oxidize eugenol. No...
article 1996
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TNO Preventie en Gezondheid Gaubius Instituut TNO (author), Sier, C.F.M. (author), Kubben, F.J.G.M. (author), Ganesh, S. (author), Heerding, M.M. (author), Griffioen, G. (author), Hanemaaijer, R. (author), van Krieken, J.H.J.M. (author), Lamers, C.B.H.W. (author), Verspaget, H.W. (author)
Proteinases are involved in tumour invasion and metastasis. Several matrix metalloproteinases (MMPs) have been shown to be increased in various human carcinomas. We assessed the levels of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in 50 gastric carcinomas and corresponding mucosa using quantitative gelatin zymography. Both MMP levels were...
article 1996
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TNO Preventie en Gezondheid (author), Biasucci, L.M. (author), Liuzzo, G. (author), Caligiuri, G. (author), Quaranta, G. (author), Andreotti, F. (author), Sperti, G. (author), van de Greef, W. (author), Rebuzzi, A.G. (author), Kluft, C. (author), Maseri, A. (author)
Background: Although a major role of coronary thrombosis in the pathogenesis of unstable angina has been demonstrated, the results of a series of studies have suggested that activation of the hemostatic system may not be confined to ischemic episodes. The purpose of this study was to investigate the temporal relation between ischemic episodes...
article 1996
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Velthuis-te Wierik, E.J.M. (author), Meijer, P. (author), Kluft, C. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Impaired fibrinolytic activity has been reported in the elderly and is thought to play a role in the etiology of cardiovascular disease, one of the leading causes of death in most Western countries. Since restriction of energy intake has been demonstrated to act beneficially on the aging process in a variety of species, we studied the effect of...
article 1995
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van Vliet, T. (author), Schreurs, W.H.P. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Postprandial response curves of β-carotene and retinyl esters in a triglyceride-rich lipoprotein (TRL) fraction were evaluated as a potential measure of β-carotene uptake and cleavage. β-Carotene, retinyl ester, and triglyceride concentrations in the TRI, fraction (density < 1.006 kg/L) and plasma were measured in 10 men for 8 or 16 h after an...
article 1995
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de Rijke, Y.B. (author), Verwey, H.F. (author), Vogelezang, C.J.M. (author), van der Velde, E.A. (author), Princen, H.M.G. (author), van der Laarse, A. (author), Bruschke, A.V.G. (author), van Berkel, T.J.C. (author), Gaubius Instituut TNO (author)
Oxidation of low-density lipoprotein (LDL) may play a causal role in atherosclerosis. In this study we analyzed whether the severity of progression of coronary atherosclerosis is related to the susceptibility of LDL to oxidative modification. On the basis of repeated coronary angiography, 28 coronary bypass patients were divided into two groups:...
article 1995
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Haider, A.W. (author), Andreotti, F. (author), Hackett, D.R. (author), Tousoulis, D. (author), Kluft, C. (author), Maseri, A. (author), Davies, G.J. (author), Gaubius Instituut TNO (author)
Objectives. This study investigated the influence of early spontaneous intermittent reperfusion on the extent of myocardial damage and its relation to endogenous hemostatic activity, Background. In the early phase of acute myocardial infarction coronary occlusion is often intermittent, even before thrombolytic therapy is administered. The...
article 1995
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Myrup, B. (author), Hansen, P.M. (author), Jensen, T. (author), Kofoed-Enevoldsen, A. (author), Feldt-Rasmussen, B. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Deckert, T. (author), Gaubius Instituut TNO (author)
We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low...
article 1995
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van Poppel, G. (author), Hospers, J. (author), Nieuwenhuizen, W. (author), Laterveer, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A high intake of β-carotene has been associated with a decreased risk for cardiovascular disease. To evaluate whether β-carotene may exert a protective effect through an impact on haemostasis a randomized, placebo-controlled trial was conducted in male smokers (n = 149) using 20 mg/day β-carotene for 14 weeks. For comparisons, haemostatic...
article 1995
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Hirasing, R.A. (author), Verrips, G.H. (author), Burgmeijer, R.J.F. (author), Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author)
Objective. To establish the participation in a number of effective prevention programmes for infants of Turkish, Maroccan, Chinese and Vietnamese inhabitants of the four major cities in the Netherlands. Design. Enquiry. Setting. Health centres in Amsterdam, Rotterdam, The Hague and Utrecht. Method. Health centre staff members in 1994 asked 194...
article 1995
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Kardinaal, A.F.M. (author), Aro, A. (author), Kark, J.D. (author), Riemersma, R.A. (author), van 't Veer, P. (author), Gomez-Aracena, J. (author), Kohlmeier, L. (author), Ringstad, J. (author), Martin, B.C. (author), Mazaev, V.P. (author), Delgado-Rodriguez, M. (author), Thamm, M. (author), Huttunen, J.K. (author), Martin-Moreno, J.M. (author), Kok, F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Because antioxidants may play a role in the prevention of coronary heart disease by inhibiting the peroxidation of polyunsaturated fatty acids (PUFAs), the combined association of diet-derived antioxidants and PUFAs with acute myocardial infarction (MI) was investigated. This multicenter case- control study included 674 patients and 725 control...
article 1995
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Velthuis-te Wierik, E.J.M. (author), van Leeuwen, R.E.W. (author), Hendriks, H.F.J. (author), Verhagen, H. (author), Loft, S. (author), Poulsen, H.E. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Restriction of energy intake (ER), without malnutrition of essential nutrients, has repeatedly been demonstrated to increase longevity in rodents. In the antioxidant theory of aging the lack of balance between the generation of free radicals and free radical scavenging was thought to be a main causal agent in the aging process. From this point...
article 1995
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Otter, M. (author), Kuiper, J. (author), Rijken, D. (author), van Zonneveld, A.-J. (author), TNO Preventie en Gezondheid (author)
To characterize the primary structure of rat Vn, a cDNA library constructed from freshly isolated rat hepatocytes, was screened with a human Vn cDNA probe. Comparison of the sequence of the obtained rat cDNA clone with the sequences of human, mouse and rabbit Vn cDNA's showed predominantly consensus in the somatomedin B domain, the RGD-sequence...
article 1995
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Kalsbeek, H. (author), van Tiel, J.P. (author), Verrips, G.H. (author), Poorterman, J.H. (author)
In order to evaluate the results of Regional Institutions (RI's) for Youth Dentistry, an epidemiological study was performed on caries experience and oral hygiene habits of 5-, 8- and 11-year-olds, getting dental treatment in these institutions. In the big cities participants of the RI's appeared to be mostly from the lower social levels of...
article 1994
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Smits, R.C.F. (author), Emmen, H.H. (author), Bertelmans, F.W. (author), Kulig, B.M. (author), van Loenen, A.C. (author), Polman, C.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could...
article 1994
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Nijhuis, E. (author), Hinloopen, B. (author), van Duijn, C. (author), Hofman, A. (author), Rozing, J. (author), Nagelkerken, L. (author), Section of Immunology, Inst. of Aging and Vascular Research, TNO, Leiden, Netherlands TNO Preventie en Gezondheid (author)
Cortisol levels in patients with Alzheimer's disease (AD) are relatively unaffected by a challenge with dexamethasone (DEX) in vivo. The present study demonstrates that DEX is less inhibitory for phytohemagglutinin (PHA)-induced T cell proliferation in AD patients as compared to age-matched controls. Since no significant differences were found...
article 1994
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Verrips, G.H. (author), Kalsbeek, H. (author)
This article reviews the literature on child dental caries in various ethnic groups in the Netherlands. Material from fifteen studies showed generally the dental health of five- to eleven-year-old children of parents born in Turkey or Morocco to be far worse than that of children of Dutch or Surinamese parents. The ethnic groups distinguished,...
article 1993
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Verrips, G.H. (author), Kalsbeek, H. (author), Frencken, J.E. (author), ter Horst, G. (author), Filedt Kok-Weimar, T.L. (author)
A previous study has shown five-year-old children of parents originating from Turkey or Morocco to have twice as much dmfs as children of parents from The Netherlands, Surinam or various other countries. In the present study, other risk indicators and factors for the prevalence of caries amongst these children were studied by interviewing their...
article 1993
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