- document
-
Wijlhuizen, G.J. (author), Chorus, A.M.J. (author), Hopman-Rock, M. (author), TNO Kwaliteit van Leven (author)Background: In their letters to the editor, Lacherez et al. [Lacherez, P.F., Wood, J.M., Kerr, G.K., 2007. Does activity level mediate or suppress the association between fear of falling and falls? Prev. Med. 31; (Electronic publication ahead of print)] and Hafeman and Schwartz [Hafeman, D., Schwartz, S., 2007. Assessing mediation: The necessity...article 2008
- document
-
The Effect of Preconception Counselling on Lifestyle and Other Behaviour Before and During PregnancyElsinga, J. (author), de Jong-Potjer, L.C. (author), van der Pal-de Bruin, K.M. (author), le Cessie, S. (author), Assendelft, W.J.J. (author), Buitendijk, S.E. (author), TNO Kwaliteit van Leven (author)Background: Recent studies suggest that the basis for adverse pregnancy outcomes is often established early in pregnancy, during organogenesis. It is therefore important to take preventive action as early as possible, preferably before pregnancy. Because most adverse pregnancy outcomes occur in women who are unaware of being at risk, we...article 2008
- document
-
Smits, K.M. (author), Schouten, L.J. (author), van Dijk, B.A.C. (author), van Houwelingen, K. (author), van de Hulsbergen-Kaa, C.A. (author), Kiemeney, L.A.L.M. (author), van Houwelingen, K. (author), Goldbohm, R.A. (author), Oosterwijk, E. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Metabolic gene polymorphisms have previously been suggested as risk factors for renal cell carcinoma (RCC). These polymorphisms are involved in activation or detoxification of carcinogens in cigarette smoke which is another RCC risk factor. We evaluated gene-environment interactions between CYP1A1, GSTμ1 and smoking in a large population-based...article 2008
- document
-
Bongaerts, B.W.C. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), de Goeij, A.F.P.M. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. Analyses...article 2008
- document
-
Wiefferink, C.H. (author), Detmar, S.B. (author), Coumans, B. (author), Vogels, T. (author), Paulussen, T.G.W. (author), TNO Kwaliteit van Leven (author)The aim of this study is to identify the social psychological determinants of the use of performance-enhancing drugs by gym users who practice bodybuilding, fitness, powerlifting or combat sports. In this questionnaire-based study, 144 respondents answered questions on their actual use and intention to use such drugs and also on their background...article 2008
- document
-
Beulens, J.W.J. (author), de Zoete, E.C. (author), Kok, F.J. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)Objective: Moderate alcohol consumption is associated with a decreased risk of type II diabetes. This study investigates the effect of moderate alcohol consumption on adipokines and insulin sensitivity. Subjects: Twenty healthy, lean (body mass index (BMI) 18.5-25 kg/m2; n=11) or overweight (BMI>27 kg/m2; n=9) men (18-25 years). Methods: Three...article 2008
- document
-
de Vogel, S. (author), Dindore, V. (author), van Engeland, M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)Adequate intake of folate, methionine, riboflavin, and vitamin B-6 may prevent aberrant DNA methylation and thereby protect against colorectal cancer (CRC). However, previous epidemiological studies investigating associations between dietary intakes of these nutrients and CRC have been inconsistent. We investigated the associations between...article 2008
- document
-
Mitea, C. (author), Havenaar, R. (author), Wouter Drijfhout, J. (author), Edens, L. (author), Dekking, L. (author), Koning, F. (author), Dekking, E.H.A. (author), TNO Kwaliteit van Leven (author)Background: Coeliac disease is caused by an immune response to gluten. As gluten proteins are proline rich they are resistant to enzymatic digestion in the gastrointestinal tract, a property that probably contributes to the immunogenic nature of gluten. Aims: This study determined the efficiency of gluten degradation by a post-proline cutting...article 2008
- document
-
Martens, M.K. (author), van Assema, P. (author), Paulussen, T.G.W.M. (author), van Breukelen, G. (author), Brug, J. (author), TNO Kwaliteit van Leven (author)Objective: The aim of this study was to assess the behavioural effects of a school-based healthful diet promotion intervention implemented in lower vocational schools. Design: A cluster-randomised pre-test-post-test experimental design was used, and data were collected by means of written questionnaires. Setting: Students of 18 Dutch lower...article 2008
- document
-
Hogervorst, J.G.F. (author), Schouten, L.J. (author), Konings, E.J.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Acrylamide is a probable human carcinogen that was detected in several heat-treated foods, such as French fries and crisps, in 2002. Prospective studies are needed on acrylamide and human cancer risk. We prospectively investigated the association between acrylamide and gastrointestinal cancer risk. In 1986, 120,852 men and women (aged 55-69 y)...article 2008
- document
-
Dekking, E.H.A. (author), van Veelen, P.A. (author), de Ru, A. (author), Kooy-Winkelaar, E.M.C. (author), Gröneveld, T. (author), Nieuwenhuizen, W.F. (author), Koning, F. (author), TNO Kwaliteit van Leven (author)Celiac disease (CD) is a permanent intolerance to gluten. In CD patients, gluten peptides cause an inflammation in the small intestine leading to tissue damage. Tissue transglutaminase (tTG) is an enzyme involved in the repair of damaged tissue by crosslinking of extracellular matrix proteins. Under certain conditions, tTG can deamidate...article 2008
- document
-
van Boxtel, E.L. (author), van den Broek, L.A.M. (author), Koppelman, S.J. (author), Gruppen, H. (author), TNO Kwaliteit van Leven (author)Legumin proteins Ara h 3 from peanuts and glycinin from soybeans are increasingly described as important allergens. The stability of an allergen's IgE binding capacity towards heating and digestion is considered an important characteristic for food allergens. We investigated the effects of heating and digestion on the IgE binding of Ara h 3 and...article 2008
- document
-
Eijkemans, M. (author), Mommers, M. (author), de Vries, S.I. (author), van Buuren, S. (author), Stafleu, A. (author), Bakker, I. (author), Thijs, C. (author), TNO Kwaliteit van Leven (author)OBJECTIVE. Prevalence of asthma and overweight has increased simultaneously during the past decades. Several studies have reported an association between these two health problems, but it is unclear whether this relation is causal. We hypothesize that children with asthmatic symptoms are less physically active, which may contribute to the...article 2008
- document
-
Hille, E.T.M. (author), Dorrepaal, C. (author), Perenboom, R. (author), Gravenhorst, J.B. (author), Brand, R. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)Objective: To assess social lifestyle, risk-taking behavior, and psychopathology in young adults born very preterm or with a very low birthweight. Study design: This study was part of the 19-year follow-up in a large ongoing collaborative study in the Netherlands (the POPS study) on the long-term outcome of prematurity and dysmaturity. 656...article 2008
- document
-
Kaptein, S. (author), Jansen, D.E.M.C. (author), Vogels, A.G.C. (author), Reijneveld, S.A. (author), TNO Kwaliteit van Leven (author)Background: The assessment of mental health problems in children with intellectual disability (ID) mostly occurs by filling out long questionnaires that are not always validated for children without ID. The aim of this study is to assess the differences in mental health problems between children with ID and without ID, using a short...article 2008
- document
- van Buuren, S. (author) article 2008
- document
-
Kocken, P.L. (author), Zwanenburg, E.J.-v. (author), de Hoop, T. (author), TNO Kwaliteit van Leven (author)Objective: : The effectiveness of use of migrant health educators in the general practitioners' care for female migrants with psychosomatic problems was evaluated to contribute to the improvement of the care for these patients. Methods: : A randomised controlled trial (RCT) design was used. A total of 104 patients (75%) agreed to take part in...article 2008
- document
-
Boomsma, D.I. (author), Willemsen, G. (author), Sullivan, P.F. (author), Heutink, P. (author), Meijer, P. (author), Sondervan, D. (author), Kluft, C. (author), Smit, G. (author), Nolen, W.A. (author), Zitman, F.G. (author), Smit, J.H. (author), Hoogendijk, W.J. (author), van Dyck, R. (author), de Geus, E.J.C. (author), Penninx, B.W.J.H. (author), TNO Kwaliteit van Leven (author)To identify the genomic regions that confer risk and protection for major depressive disorder (MDD) in humans, large-scale studies are needed. Such studies should collect multiple phenotypes, DNA, and ideally, biological material that allows gene expression analysis, transcriptomic, proteomic, and metabolomic studies. In this paper, we briefly...article 2008
- document
-
Vogels, A.G.C. (author), Jacobusse, G.W. (author), Hoekstra, F. (author), Brugman, E. (author), Crone, M. (author), Reijneveld, S.A. (author), TNO Kwaliteit van Leven (author)Objective: To assess whether differences between individual Preventive Child Health Care (PCH) professionals in the percentage of children they identify as having psychosocial problems are larger than expected based on chance and whether such differences can be explained by differences in parent-reported problems or risk indicators. Study Design...article 2008
- document
- van Herten, L. (author), TNO Kwaliteit van Leven (author) report 2008