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Niks, I.M.W. (author), Gevers, J.M.P. (author), de Jonge, J. (author), Houtman, I.L.D. (author)Effective interventions to prevent work stress and to improve health, well-being, and performance of employees are of the utmost importance. This quasi-experimental intervention study presents a specific method for diagnosis of psychosocial risk factors at work and subsequent development and implementation of tailored work stress interventions,...article 2018
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Spriensma, A.S. (author), Eekhout, I. (author), de Boer, M.R. (author), Luime, J.J. (author), de Jong, P.H. (author), Bahçecitapar, M.K. (author), Heymans, M.W. (author), Twisk, J.W.R. (author)Background: Randomised controlled trials (RCTs) are the gold standard to estimate treatment effects. When patients receive effective treatment over time they may reach the limit of a certain measurement scale. This phenomenon is known as censoring and leads to skewed distributions of the outcome variable with an excess of either low (floor...article 2018
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Morrison, M.C. (author), Kleemann, R. (author), van Koppen, A. (author), Hanemaaijer, R. (author), Verschuren, L. (author)Introduction: It is generally accepted that metabolic inflammation in the liver is an important driver of disease progression in NASH and associated matrix remodeling/fibrosis. However, the exact molecular inflammatory mechanisms are poorly defined in human studies. Investigation of key pathogenic mechanisms requires the use of pre-clinical...article 2018
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van der Kleij, R. (author), Hueting, T.F. (author), Schraagen, J.M.C. (author)Dynamic Positioning (DP) is a computer-controlled process to automatically keep a floating vessel at a specific position or to follow a pre-defined path (tracking) by using its own propellers and thrusters. The human supervisory controller has no direct need to constantly know what the status is of all parts of the automation and the system it...article 2018
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Smith, L.K. (author), Hindori-Mohangoo, A.D. (author), Delnord, M. (author), Durox, M. (author), Szamotulska, K. (author), Macfarlane, A. (author), Barros, H. (author), Gissler, M. (author), Blondel, B. (author), Zeitlin, J. (author)Background. International comparisons of stillbirth allow assessment of variations in clinical practice to reduce mortality. Currently, such comparisons include only stillbirths from 28 or more completed weeks of gestational age, which underestimates the true burden of stillbirth. With increased registration of early stillbirths in high-income...article 2018
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Dhondt, S. (author), Oeij, P.R.A. (author), Schröder, A. (author)Human and financial resources as well as organisational capabilities are needed to overcome the manifold constraints social innovators are facing. To unlock the potential of social innovation for the whole society new (social) innovation friendly environments and new governance structures (ecosystems) have to be set-up to foster social...bookPart 2018
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Oeij, P.R.A. (author), Dhondt, S. (author), Ooms, M. (author)The Netherlands is catching up with social innovation. In the former century combating social problems was a task of public organisations and government, largely carried out top down. Today the responsibility to tackle social issues is partly shifting to public-private partnerships, social enterprises and communities.bookPart 2018
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Shankar, K. (author), Pivik, R.T. (author), Johnson, S.L. (author), van Ommen, B. (author), Demmer, E. (author), Murray, R. (author)Understanding health requires more than knowledge of the genome. Environmental factors regulate gene function through epigenetics. Collectively, environmental exposures have been called the "exposome." Caregivers are instrumental in shaping exposures in a child's initial years. Maternal dietary patterns, physical activity, degree of weight gain,...article 2018
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Tielman, M.L. (author), Neerincx, M.A. (author), van Meggelen, M. (author), Franken, I. (author), Brinkman, W.P. (author)BACKGROUND AND OBJECTIVE: With the rise of autonomous e-mental health applications, virtual agents can play a major role in improving trustworthiness, therapy outcome and adherence. In these applications, it is important that patients adhere in the sense that they perform the tasks, but also that they adhere to the specific recommendations on...article 2017
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Leist, M. (author), Ghallab, A. (author), Graepel, R. (author), Marchan, R. (author), Hassan, R. (author), Bennekou, S.H. (author), Limonciel, A. (author), Vinken, M. (author), Schildknecht, S. (author), Waldmann, T. (author), Danen, E. (author), van Ravenzwaay, B. (author), Kamp, H. (author), Gardner, I. (author), Godoy, P. (author), Bois, F.Y. (author), Braeuning, A. (author), Reif, R. (author), Oesch, F. (author), Drasdo, D. (author), Höhme, S. (author), Schwarz, M. (author), Hartung, T. (author), Braunbeck, T. (author), Beltman, J. (author), Vrieling, H. (author), Sanz, F. (author), Forsby, A. (author), Gadaleta, D. (author), Fisher, C. (author), Kelm, J. (author), Fluri, D. (author), Ecker, G. (author), Zdrazil, B. (author), Terron, A. (author), Jennings, P. (author), van der Burg, B. (author), Dooley, S. (author), Meijer, A.H. (author), Willighagen, E. (author), Martens, M. (author), Evelo, C. (author), Mombelli, E. (author), Taboureau, O. (author), Mantovani, A. (author), Hardy, B. (author), Koch, B. (author), Escher, S. (author), van Thriel, C. (author), Cadenas, C. (author), Kroese, D. (author), van de Water, B. (author), Hengstler, J.G. (author)Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event...article 2017
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Brix, K.A. (author), Brody, D.L. (author), Grimes, J.B. (author), Yitzhak, A. (author), Agoston, D. (author), Aldag, M. (author), Armstrong, R. (author), Arun, P. (author), Audette, M. (author), Babcock, D. (author), Balaban, C. (author), Banton, R. (author), Bellgowan, P. (author), Borkholder, D. (author), Broglio, S. (author), Brokaw, E. (author), Cantu, R. (author), Carr, W. (author), Chapman, S. (author), Cmarik, J. (author), Colder, B. (author), Colombe, J. (author), Cook, D. (author), Cozzarelli, T. (author), Da Silva, U.O. (author), Daphalapurkar, N. (author), Dardzinski, B. (author), DeGraba, T. (author), DeMar, J. (author), DeWitt, D. (author), Dickstein, D. (author), Duckworth, J. (author), Elder, G. (author), Fazel-Rezai, R. (author), Fine, M. (author), Fiskum, G. (author), Fournier, A. (author), Ganpule, S. (author), Gill, J. (author), Glenn, J.F. (author), Greene, C. (author), Greig, N. (author), Haering, C. (author), Harrington, J. (author), Hein, A. (author), Helmick, K. (author), Hicks, R. (author), Hinds, S. (author), Hoffman, S. (author), Horkayne-Szakaly, I. (author), Iacono, D. (author), Ishii, E. (author), Jones, R.V. (author), Karami, G. (author), Krawczyk, D. (author), Labutta, R. (author), Latta, R. (author), Lattimore, T. (author), Leggieri, M. (author), Leonessa, F. (author), Lin, A. (author), Ling, G. (author), Long, M. (author), Lu, K.P. (author), Panker, S.M. (author), McCabe, J. (author), Merkle, A. (author), Montenigro, P. (author), Mueller, G.P. (author), Ng, L. (author), Nigam, S. (author), O'Donnell, J. (author), Okonkwo, D. (author), Pauli, I. (author), Perl, D. (author), Peskind, E. (author), Pfister, B. (author), Philippens, M. (author), Piehler, T. (author), Proctor, J. (author), Przekwas, A. (author), Qashu, F. (author), Raskind, M. (author), Razumovsky, A. (author), Reifman, J. (author), Reyes, P. (author), Rigby, P. (author), Risling, M. (author), Robinson, M. (author), Rooks, T. (author), Rosen, C. (author), Rosseau, G. (author), Sammons-Jackson, W. (author), Santago, A. (author), Shoge, R. (author), Sours, C. (author), Stone, J. (author), Templin, M. (author), Tepe, V. (author), Thielen, P. (author), Thomas, M. (author), Timmes, T. (author), Tortella, F. (author), Tucker, L. (author), Tweedie, D. (author), Hamm, D.V. (author), Christie Vu, B. (author), Wang, Y. (author), West, T. (author), Wilde, E. (author), Willis, A. (author), Wu, J. (author), Zai, L. (author), Zander, N. (author), Zheng, J. (author), Ziejewski, M. (author)The potential relationship between chronic traumatic encephalopathy (CTE) and head injuries such as blast-related traumatic brain injury (TBI) is an important area of study, particularly for military and contact sports populations, yet little is known about this relationship. To address this topic, the Department of Defense (DoD) Blast Injury...article 2017
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Kruisdijk, F. (author), Deenik, J. (author), Yenback, D. (author), Tak, E.C. (author), van Harten, P. (author), Hopman-Rock, M. (author), Hendriksen, I. (author)Sedentary behaviour and lack of physical activity threatens health. Research concerning these behaviours of inpatients with severe mental illness is limited but urgently needed to reveal prevalence and magnitude. In total, 184 inpatients (men n =108, women n =76, mean age 57,4, 20% first generation antipsychotics, 40% second generation...article 2017
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Kasiotis, K.M. (author), Tsakirakis, A.N. (author), Richard Glass, C. (author), Charistou, A.N. (author), Anastassiadou, P. (author), Gerritsen-Ebben, R. (author), Machera, K. (author)A dislodgeable foliar residue study was conducted in greenhouse pepper and tomato on the island of Crete, Greece, following the spray application of an SC insecticide (with active substance (a.s.) tebufenozide) and an EC fungicide (a.s. bupirimate). Furthermore, for the assessment of worker exposure to pesticides – as a result of re-entering the...article 2017
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Stolte, E. (author), Hopman-Rock, M. (author), Aartsen, M.J. (author), van Tilburg, T.G. (author), Chorus, A. (author)The predictive value of the Theory of Planned Behavior (TPB) on intention and physical activity (PA) over time was examined. Data from the Aging Well and Healthily intervention program (targeting perceived behavioral control and attitude, not subjective norm) were analyzed, including pretest (T0), posttest (T1, except subjective norm) and 4-6...article 2017
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Siddiqui, A. (author), Cuttini, M. (author), Wood, R. (author), Velebil, P. (author), Delnord, M. (author), Zile, I. (author), Barros, H. (author), Gissler, M. (author), Hindori-Mohangoo, A.D. (author), Blondel, B. (author), Zeitlin, J. (author), Haidinger, G. (author), Alexander, S. (author), Pavlou, P. (author), Mortensen, L. (author), Sakkeus, L. (author), Lack, N. (author), Antsaklis, A. (author), Berbik, I. (author), Ólafsdóttir, H.S. (author), Bonham, S. (author), Misins, J. (author), Jaselioniene, J. (author), Wagener, Y. (author), Gatt, M. (author), Nijhuis, J. (author), Klungsøyr, K. (author), Szamotulska, K. (author), Horga, M. (author), Cap, J. (author), Mandić, N.T. (author), Bolúmar, F. (author), Gottvall, K. (author), Berrut, S. (author), Macfarlane, A. (author), Euro-Peristat Scientific Committee (author)Background: The Apgar score has been shown to be predictive of neonatal mortality in clinical and population studies, but has not been used for international comparisons. We examined population-level distributions in Apgar scores and associations with neonatal mortality in Europe. Methods: Aggregate data on the 5 minute Apgar score for live...article 2017
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Rubenstein, C.D. (author), den Hartog, E.A. (author), Deaton, A.S. (author), Bogerd, C.P. (author), de Kant, S. (author)A major concern for responders to hazardous materials (HazMat) incidents is the heat strain that is caused by fully encapsulated impermeable chemical protective suits. In a research project, funded by the US Department of Defense, the thermal strain experienced when wearing these suits was studied. One particular area of interest was the fluid...article 2017
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Bezem, J. (author), van der Ploeg, C. (author), Numans, M. (author), Buitendijk, S. (author), Kocken, P. (author), van der Akker, E. (author)Background. Triage in Preventive Child Health Care (PCH) assessments could further the efficient use of human resources and budgets and therefore make extra care possible for children with specific needs. We assessed the costs of routine PCH assessments with and without triage for children aged 5/6 years and 10/11 years. In a triage approach,...article 2017
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Boesveld, I.C. (author), Bruijnzeels, M.A. (author), Hitzert, M. (author), Hermus, M.A.A. (author), van der Pal-de Bruin, K.M. (author), van den Akker-van Marle, M.E. (author), Steegers, E.A.P. (author), Franx, A. (author), de Vries, R.G. (author), Wiegers, T.A. (author)Background: The goal of integrated care is to offer a continuum of care that crosses the boundaries of public health, primary, secondary, and tertiary care. Integrated care is increasingly promoted for people with complex needs and has also recently been promoted in maternity care systems to improve the quality of care. Especially when located...article 2017
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Boesveld, I.C. (author), Valentijn, P.P. (author), Hitzert, M. (author), Hermus, M.A.A. (author), Franx, A. (author), de Vries, R.G. (author), Wiegers, T.A. (author), Bruijnzeels, M.A. (author)Introduction: Integrated care is considered to be a means to reduce costs, improve the quality of care and generate better patient outcomes. At present, little is known about integrated care in maternity care systems. We developed questionnaires to examine integrated care in two different settings, using the taxonomy of the Rainbow Model of...article 2017
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Hermus, M.A.A. (author), Boesveld, I.C. (author), Hitzert, M. (author), Franx, A. (author), de Graaf, J.P. (author), Steegers, E.A.P. (author), Wiegers, T.A. (author), van der Pal-de Bruin, K.M. (author)Background: During the last decade, a rapid increase of birth locations for low-risk births, other than conventional obstetric units, has been seen in the Netherlands. Internationally some of such locations are called birth centres. The varying international definitions for birth centres are not directly applicable for use within the Dutch...article 2017