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Joustra, S.D. (author), van der Plas, E.M. (author), Goede, J. (author), Oostdijk, W. (author), Delemarre-van de Waal, H.A. (author), Hack, W.W.M. (author), van Buuren, S. (author), Wit, J.M. (author)Aim Accurate calculations of testicular volume standard deviation (SD) scores are not currently available. We constructed LMS-smoothed age-reference charts for testicular volume in healthy boys. Methods The LMS method was used to calculate reference data, based on testicular volumes from ultrasonography and Prader orchidometer of 769 healthy...article 2015
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de Beer, F. (author), van Dijk, K.W. (author), Jong, M.C. (author), van Vark, L.C. (author), van der Zee, A. (author), Hofker, M.H. (author), Fallaux, F.J. (author), Hoeben, R.C. (author), Smelt, A.H.M. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)The apolipoprotein E2 (Lys146→Gln) variant is associated with a dominant form of familial dysbetalipoproteinemia. Heterozygous carriers of this variant have elevated levels of plasma triglycerides, cholesterol, and apolipoprotein E (apoE). It was hypothesized that the high amounts of triglycerides in the very low density lipoprotein (VLDL)...article 2000
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Dagnelie, P.C. (author), Schuurman, A.G. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding (author)We reviewed 37 prospective cohort and four intervention studies on potential dietary risk factors for prostate cancer, published between 1966 and September 2003. Some studies were limited by small size, crude measurement of dietary exposure and limited control for confounders. Intervention and prospective cohort studies support a protective role...article 2004
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Hooisma, J. (author), Twisk, D.A.M. (author), Platalla, S. (author), Muijser, H. (author), Kulig, B.M. (author), Medisch Biologisch Laboratorium TNO (author)The performance characteristics of 4 computerized psychological tests were studied using alcohol as a model compound. Subjects received alcohol (0.5 ml/kg) or placebo in a cross-over design and performance was assessed using the Simple Reaction Time test, the Switching Attention test, the Hand/Eye Coordination test and the Color-Word Vigilance...article 1988
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van den Broeck, J. (author), Brand, R. (author), Massa, G. (author), Herngreen, W.P. (author), Wit, J.M. (author), TNO Preventie en Gezondheid (author)According to the ICP (infancy-childhood-puberty) growth model, statural growth can be divided into three partially superimposed components assumed to represent different physiologic mechanisms. This model predicts a sudden acceleration of length velocity (LV) at the onset of the childhood component around 9 months. The existence of such an...article 2000
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Kalanda, B.F. (author), van Buuren, S. (author), Verhoeff, F.H. (author), Brabin, B.J. (author), TNO Kwaliteit van Leven (author)The aim of this analysis was to construct cross-sectional gestational age specific percentile curves for birthweight, length, head and mid-arm circumference for Malawian babies, and to compare these percentiles with reference values for babies born to women with normal pregnancies, from a developed country. A cross-sectional study which enrolled...article 2005
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Hirasing, R.A. (author), van Leerdam, F. (author), Bolk-Bennink, L.B. (author), Bosch, J.D. (author)Objective: To assess the link between enuresis nocturna and the severity of behavioural and/or emotional problems in Dutch children and the course of these problems. Setting: West-Mine Region in the Netherlands: Subjects and methods: Prospective cohort study involving 66 of the 80 bedwetting children from all 1652 children born in 1983 in this...article 1997
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Appelman, L.M. (author), Hendriksen, C.F.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The subacute inhalation toxicity of ??-ethylacrolein was examined in rats by repeated exposure of 4 groups of 10 males and 10 females each to ??-ethylacrolein vapour at concentrations of 0, 2.0, 9.8 or 48.4 ppm, respectively, (6 h/day, 5 days/week) for a period of 13 weeks. The effects at 48.4 ppm were found to include growth retardation, focal...article 1981
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Reijneveld, S.A. (author), Brugman, E. (author), Verhulst, F.C. (author), Verloove-Vanhorick, S.P. (author)Objectives: To assess the degree to which preventive child health professionals (CHPs) identify and manage psychosocial problems among preschool children in the general population and to determine the association with parent-reported behavioral and emotional problems, sociodemographic factors, and mental health history of children. Design: The...article 2004
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Kalsbeek, H. (author), de Baat, C. (author), Kivit, M.M. (author), de Kleijn de-Vrankrijker, M.W. (author)In this study oral health of elderly persons as perceived by the subjects was evaluated. Phenomena often mentioned were problems with chewing and biting, dry mouth, retention of food particles between teeth or below the prosthesis, (in edentates) sensitivity of teeth for warm or cold foods and (in edentates) lack of retention of the lower...article 2001
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Kater, A.P. (author), Heijboer, H. (author), Peters, M. (author), Vogels, T. (author), Prins, M.H. (author), Heymans, H.S.A. (author)Objective. To determine the differences in quality of life between children with sickle cell disease and healthy immigrant children. Design. Descriptive, comparative. Method. The quality of life of children with sickle cell disease between 5 and 15 years old being treated in the Emma Children's Hospital AMC in Amsterdam, the Netherlands, was...article 1999
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Stein, A.D. (author), Rundle, A. (author), Wada, N. (author), Goldbohm, R.A. (author), Lumey, L.H. (author), TNO Kwaliteit van Leven (author)Individuals exposed to the Dutch Famine of 1944-45 during gestation have increased adiposity, which might be due to changes in energy intake, physical activity, or metabolic efficiency.We studied 357 persons born between January 1945 and March 1946 whose mothers experienced famine during or immediately preceding pregnancy, 298 persons born in...article 2009
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Lina, B.A.R. (author), Bär, A. (author), TNO Voeding (author)The toxicity of α-cyclodextrin (α-CD), a cyclic polymer of six α-1,4-linked glucopyranosyl units with potential applications as a food ingredient, more specifically a water-soluble dietary fiber, was examined in a 4-week range finding study and a 13-week oral toxicity study in rats. In the 4-week study, the test substance was administered to...article 2004
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Hopman-Rock, M. (author), Westhoff, M.H. (author)In order to promote health in people of 65 years and older, TNO Prevention and Health developed, evaluated, and implemented "Healthy & Vital" (also known as "Ageing Well and Healthily"). Healthy & Vital consists of six sessions of health education and low-intensity exercises. This paper reports on the theoretical basis of the intervention, the...article 2002
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Eradication of Helicobacter pylori infection favourably affects altered gastric mucosal MMP-9 levelsKubben, F.J.G.M. (author), Sier, C.F.M. (author), Schram, M. (author), Witte, T.A.M.C. (author), Veenendaal, R.A. (author), van Duijn, W. (author), Verheijen, J.H. (author), Hanemaaijer, R. (author), Lamers, C.B.H.W. (author), Verspaget, H.W. (author), TNO Kwaliteit van Leven (author)Background: Helicobacter pylori gastritis is recognized as an important pathogenetic factor in peptic ulcer disease and gastric carcinogenesis, and is accompanied by strongly enhanced gastric mucosal matrix metalloproteinase-9 (MMP-9) levels. Aim: This study was performed to investigate whether H. pylori-affected gastric mucosal MMP-2 and MMP-9...article 2007
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Tuomainen, A. (author), Kangas, J.A. (author), Meuling, W.J.A. (author), Glass, R.C. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)Malathion was applied to roses in three Finnish greenhouses by hand held lance sprayers. The potential dermal exposure of applicators to this insecticide was measured. Total urine production of each applicator was also collected up to 24 h post application. In the urine samples the specific metabolite of malathion, malathion monocarboxylic acid ...article 2002
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Hildebrandt, V.H. (author), Bongers, P.M. (author), van Dijk, F.J.H. (author), Kemper, H.C.G. (author), Dul, J. (author), TNO Preventie en Gezondheid (author)An epidemiological study was carried out to explore the relationship between climatic factors and non-specific low-back and neck-shoulder symptoms in working populations. In a review of published literature, 27 studies were found which related climatic factors to musculoskeletal symptoms, but none of these studies specifically addressed the...article 2002
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Gevers Leuven, J.A. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)Lipoprotein metabolism is involved in atherogenesis. Female sex-hormones have substantial effects on both lipoprotein metabolism and the vessel wall. Cholesterol, one of the major lipids in lipoproteins, is both the substrate for, and the target of, the steroidal sex hormones.article 1994
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Lina, B.A.R. (author), Bär, A. (author), TNO Voeding (author)The oral toxicity of α-cyclodextrin (α-CD) was examined in a 13-week feeding study in which groups of Beagle dogs received α-CD in the diet at concentrations of 0 (control), 5, 10, or 20% (4dogs/sex/group). No treatment-related changes were noted in behavior or appearance of the dogs and no mortalities occurred. Diarrhea occurred in all α-CD...article 2004
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Jans, M.P. (author), Proper, K.I. (author), Hildebrandt, V.H. (author), TNO Kwaliteit van Leven (author)Background: Sedentary behavior is an independent risk factor for excess body weight and other health problems. There are no published data on sitting time at work, or how this is related to occupation and sector (branch of business). No published study has shown whether extended sitting at work is compensated for by sitting less during leisure...article 2007