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Fonseca, A.S. (author), Kuijpers, E. (author), Kling, K.I. (author), Levin, M. (author), Koivisto, A.J. (author), Nielsen, S.H. (author), Fransman, W. (author), Fedutik, Y. (author), Jensen, K.A. (author), Koponen, I.K. (author)
Fume hoods are one of the most common types of equipment applied to reduce the potential of particle exposure in laboratory environments. A number of previous studies have shown particle release during work with nanomaterials under fume hoods. Here, we assessed laboratory workers’ inhalation exposure during synthesis and handling of CuO, TiO2...
article 2018
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Viester, L. (author), Verhagen, E.A.L.M. (author), Bongers, P.M. (author), van der Beek, A.J. (author)
Purpose: To evaluate the effectiveness of an individually tailored intervention for improvement in lifestyle behavior, health indicators, and prevention and reduction of overweight among construction workers. Design: Randomized controlled trial. Setting: Various blue-collar departments of a large construction company in the Netherlands....
article 2018
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Ding, D. (author), Neerincx, M.A. (author), Brinkman, W.P. (author)
Introduction: Inner voice is estimated to occur at least a quarter of people’s conscious waking life. Much research work asserts that inner voice plays various important roles in cognitive functions, such as self-regulation, self-reflection, and so on. Virtual cognitions are a stream of simulated thoughts people can hear while emerged in a...
article 2018
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Notenboom, S. (author), Weigand, K.M. (author), Proost, J.H. (author), van Lipzig, M.M.H. (author), van de Steeg, E. (author), van den Broek, P.H.H. (author), Greupink, R. (author), Russel, F.G.M. (author), Groothuis, G.M.M. (author)
Drug-induced liver injury (DILI) is a common reason for drug withdrawal from the market. An important cause of DILI is drug-induced cholestasis. One of the major players involved in drug-induced cholestasis is the bile salt efflux pump (BSEP; ABCB11). Inhibition of BSEP by drugs potentially leads to cholestasis due to increased (toxic)...
article 2018
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Remington, B. (author), Broekman, H.C.H. (author), Blom, W.M. (author), Capt, A. (author), Crevel, R.W.R. (author), Dimitrov, I. (author), Faeste, C.K. (author), Fernandez-Canton, R. (author), Giavi, S. (author), Houben, G.F. (author), Glenn, K.C. (author), Madsen, C.B. (author), Kruizinga, A.K. (author), Constable, A. (author)
The development and introduction of new dietary protein sources has the potential to improve food supply sustainability. Understanding the potential allergenicity of these new or modified proteins is crucial to ensure protection of public health. Exposure to new proteins may result in de novo sensitization, with or without clinical allergy, or...
article 2018
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Blanson Henkemans, O.A. (author), Keij, M. (author), Grootjen, M. (author), Kamphuis, M. (author), Dijkshoorn, A. (author)
Background: The StartingTogether program (in Dutch SamenStarten) is a family-centred method for early identification of social-emotional and behavioural problems in young children. Nurses in preventive child health care find it challenging to: determine family issues and need for care; provide education; refer to social services; increase parent...
article 2018
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de Groot, J.F. (author), Damen, N. (author), de Loos, E. (author), Goorhuis, J. (author), Wagner, C. (author)
Background: Paediatric Early Warning Scores (PEWS) are increasingly being used for early identification and management of clinical deterioration in paediatric patients. A PEWS system includes scores, cut-off points and appropriate early intervention. In 2011, The Dutch Ministry of Health advised hospitals to implement a PEWS system in order to...
article 2018
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Koopmans, L. (author), Damen, N. (author), Wagner, C. (author)
Objectives Many European countries face challenges in long-term care for older people, such as the growing number of older people requiring care, the increasing complexity of their health care problems, and a decreasing workforce that is inadequately prepared. Optimizing the staff and skill mix of health care teams may offer part of the solution...
article 2018
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Fallaize, R. (author), Livingstone, K.M. (author), Celis-Morales, C. (author), Macready, A.L. (author), San-Cristobal, R. (author), Navas-Carretero, S. (author), Marsaux, C.F.M. (author), O’Donovan, C.B. (author), Kolossa, S. (author), Moschonis, G. (author), Walsh, M.C. (author), Gibney, E.R. (author), Brennan, L. (author), Bouwman, J. (author), Manios, Y. (author), Jarosz, M. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gundersen, T.E. (author), Drevon, C.A. (author), Gibney, M.J. (author), Mathers, J.C. (author), Lovegrove, J.A. (author)
Diet-quality scores (DQS), which are developed across the globe, are used to define adherence to specific eating patterns and have been associated with risk of coronary heart disease and type-II diabetes. We explored the association between five diet-quality scores (Healthy Eating Index, HEI; Alternate Healthy Eating Index, AHEI; MedDietScore,...
article 2018
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Niks, I.M.W. (author), Gevers, J.M.P. (author), de Jonge, J. (author), Houtman, I.L.D. (author)
Effective interventions to prevent work stress and to improve health, well-being, and performance of employees are of the utmost importance. This quasi-experimental intervention study presents a specific method for diagnosis of psychosocial risk factors at work and subsequent development and implementation of tailored work stress interventions,...
article 2018
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Spriensma, A.S. (author), Eekhout, I. (author), de Boer, M.R. (author), Luime, J.J. (author), de Jong, P.H. (author), Bahçecitapar, M.K. (author), Heymans, M.W. (author), Twisk, J.W.R. (author)
Background: Randomised controlled trials (RCTs) are the gold standard to estimate treatment effects. When patients receive effective treatment over time they may reach the limit of a certain measurement scale. This phenomenon is known as censoring and leads to skewed distributions of the outcome variable with an excess of either low (floor...
article 2018
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Morrison, M.C. (author), Kleemann, R. (author), van Koppen, A. (author), Hanemaaijer, R. (author), Verschuren, L. (author)
Introduction: It is generally accepted that metabolic inflammation in the liver is an important driver of disease progression in NASH and associated matrix remodeling/fibrosis. However, the exact molecular inflammatory mechanisms are poorly defined in human studies. Investigation of key pathogenic mechanisms requires the use of pre-clinical...
article 2018
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van der Kleij, R. (author), Hueting, T.F. (author), Schraagen, J.M.C. (author)
Dynamic Positioning (DP) is a computer-controlled process to automatically keep a floating vessel at a specific position or to follow a pre-defined path (tracking) by using its own propellers and thrusters. The human supervisory controller has no direct need to constantly know what the status is of all parts of the automation and the system it...
article 2018
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Smith, L.K. (author), Hindori-Mohangoo, A.D. (author), Delnord, M. (author), Durox, M. (author), Szamotulska, K. (author), Macfarlane, A. (author), Barros, H. (author), Gissler, M. (author), Blondel, B. (author), Zeitlin, J. (author)
Background. International comparisons of stillbirth allow assessment of variations in clinical practice to reduce mortality. Currently, such comparisons include only stillbirths from 28 or more completed weeks of gestational age, which underestimates the true burden of stillbirth. With increased registration of early stillbirths in high-income...
article 2018
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Shankar, K. (author), Pivik, R.T. (author), Johnson, S.L. (author), van Ommen, B. (author), Demmer, E. (author), Murray, R. (author)
Understanding health requires more than knowledge of the genome. Environmental factors regulate gene function through epigenetics. Collectively, environmental exposures have been called the "exposome." Caregivers are instrumental in shaping exposures in a child's initial years. Maternal dietary patterns, physical activity, degree of weight gain,...
article 2018
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Tielman, M.L. (author), Neerincx, M.A. (author), van Meggelen, M. (author), Franken, I. (author), Brinkman, W.P. (author)
BACKGROUND AND OBJECTIVE: With the rise of autonomous e-mental health applications, virtual agents can play a major role in improving trustworthiness, therapy outcome and adherence. In these applications, it is important that patients adhere in the sense that they perform the tasks, but also that they adhere to the specific recommendations on...
article 2017
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Leist, M. (author), Ghallab, A. (author), Graepel, R. (author), Marchan, R. (author), Hassan, R. (author), Bennekou, S.H. (author), Limonciel, A. (author), Vinken, M. (author), Schildknecht, S. (author), Waldmann, T. (author), Danen, E. (author), van Ravenzwaay, B. (author), Kamp, H. (author), Gardner, I. (author), Godoy, P. (author), Bois, F.Y. (author), Braeuning, A. (author), Reif, R. (author), Oesch, F. (author), Drasdo, D. (author), Höhme, S. (author), Schwarz, M. (author), Hartung, T. (author), Braunbeck, T. (author), Beltman, J. (author), Vrieling, H. (author), Sanz, F. (author), Forsby, A. (author), Gadaleta, D. (author), Fisher, C. (author), Kelm, J. (author), Fluri, D. (author), Ecker, G. (author), Zdrazil, B. (author), Terron, A. (author), Jennings, P. (author), van der Burg, B. (author), Dooley, S. (author), Meijer, A.H. (author), Willighagen, E. (author), Martens, M. (author), Evelo, C. (author), Mombelli, E. (author), Taboureau, O. (author), Mantovani, A. (author), Hardy, B. (author), Koch, B. (author), Escher, S. (author), van Thriel, C. (author), Cadenas, C. (author), Kroese, D. (author), van de Water, B. (author), Hengstler, J.G. (author)
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event...
article 2017
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Brix, K.A. (author), Brody, D.L. (author), Grimes, J.B. (author), Yitzhak, A. (author), Agoston, D. (author), Aldag, M. (author), Armstrong, R. (author), Arun, P. (author), Audette, M. (author), Babcock, D. (author), Balaban, C. (author), Banton, R. (author), Bellgowan, P. (author), Borkholder, D. (author), Broglio, S. (author), Brokaw, E. (author), Cantu, R. (author), Carr, W. (author), Chapman, S. (author), Cmarik, J. (author), Colder, B. (author), Colombe, J. (author), Cook, D. (author), Cozzarelli, T. (author), Da Silva, U.O. (author), Daphalapurkar, N. (author), Dardzinski, B. (author), DeGraba, T. (author), DeMar, J. (author), DeWitt, D. (author), Dickstein, D. (author), Duckworth, J. (author), Elder, G. (author), Fazel-Rezai, R. (author), Fine, M. (author), Fiskum, G. (author), Fournier, A. (author), Ganpule, S. (author), Gill, J. (author), Glenn, J.F. (author), Greene, C. (author), Greig, N. (author), Haering, C. (author), Harrington, J. (author), Hein, A. (author), Helmick, K. (author), Hicks, R. (author), Hinds, S. (author), Hoffman, S. (author), Horkayne-Szakaly, I. (author), Iacono, D. (author), Ishii, E. (author), Jones, R.V. (author), Karami, G. (author), Krawczyk, D. (author), Labutta, R. (author), Latta, R. (author), Lattimore, T. (author), Leggieri, M. (author), Leonessa, F. (author), Lin, A. (author), Ling, G. (author), Long, M. (author), Lu, K.P. (author), Panker, S.M. (author), McCabe, J. (author), Merkle, A. (author), Montenigro, P. (author), Mueller, G.P. (author), Ng, L. (author), Nigam, S. (author), O'Donnell, J. (author), Okonkwo, D. (author), Pauli, I. (author), Perl, D. (author), Peskind, E. (author), Pfister, B. (author), Philippens, M. (author), Piehler, T. (author), Proctor, J. (author), Przekwas, A. (author), Qashu, F. (author), Raskind, M. (author), Razumovsky, A. (author), Reifman, J. (author), Reyes, P. (author), Rigby, P. (author), Risling, M. (author), Robinson, M. (author), Rooks, T. (author), Rosen, C. (author), Rosseau, G. (author), Sammons-Jackson, W. (author), Santago, A. (author), Shoge, R. (author), Sours, C. (author), Stone, J. (author), Templin, M. (author), Tepe, V. (author), Thielen, P. (author), Thomas, M. (author), Timmes, T. (author), Tortella, F. (author), Tucker, L. (author), Tweedie, D. (author), Hamm, D.V. (author), Christie Vu, B. (author), Wang, Y. (author), West, T. (author), Wilde, E. (author), Willis, A. (author), Wu, J. (author), Zai, L. (author), Zander, N. (author), Zheng, J. (author), Ziejewski, M. (author)
The potential relationship between chronic traumatic encephalopathy (CTE) and head injuries such as blast-related traumatic brain injury (TBI) is an important area of study, particularly for military and contact sports populations, yet little is known about this relationship. To address this topic, the Department of Defense (DoD) Blast Injury...
article 2017
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Kruisdijk, F. (author), Deenik, J. (author), Yenback, D. (author), Tak, E.C. (author), van Harten, P. (author), Hopman-Rock, M. (author), Hendriksen, I. (author)
Sedentary behaviour and lack of physical activity threatens health. Research concerning these behaviours of inpatients with severe mental illness is limited but urgently needed to reveal prevalence and magnitude. In total, 184 inpatients (men n =108, women n =76, mean age 57,4, 20% first generation antipsychotics, 40% second generation...
article 2017
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Kasiotis, K.M. (author), Tsakirakis, A.N. (author), Richard Glass, C. (author), Charistou, A.N. (author), Anastassiadou, P. (author), Gerritsen-Ebben, R. (author), Machera, K. (author)
A dislodgeable foliar residue study was conducted in greenhouse pepper and tomato on the island of Crete, Greece, following the spray application of an SC insecticide (with active substance (a.s.) tebufenozide) and an EC fungicide (a.s. bupirimate). Furthermore, for the assessment of worker exposure to pesticides – as a result of re-entering the...
article 2017
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