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Clingen, P.H. (author), Arlett, C.F. (author), Cole, J. (author), Waugh, A.P.W. (author), Lowe, J.E. (author), Harcourt, S.A. (author), Hermanova, N. (author), Roza, L. (author), Mori, T. (author), Nikaido, O. (author), Green, M.H.L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1995
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Kluft, C. (author), Haverkate, F. (author), Koopman, J. (author), Vellenga, E. (author), Nieuwenhuis, K.N. (author), Boschman, T.A.C. (author), Jansen, J.W.C.M. (author), Gaubius Instituut TNO (author)
article 1983
document
Scott, L. (author), Eskes, C. (author), Hoffmann, S. (author), Adriaens, E. (author), Alepée, N. (author), Bufo, M. (author), Clothier, R. (author), Facchini, D. (author), Faller, C. (author), Guest, R. (author), Harbell, J. (author), Hartung, T. (author), Kamp, H. (author), Varlet, B.L. (author), Meloni, M. (author), McNamee, P. (author), Osborne, R. (author), Pape, W. (author), Pfannenbecker, U. (author), Prinsen, M. (author), Seaman, C. (author), Spielmann, H. (author), Stokes, W. (author), Trouba, K. (author), Berghe, C.V.d. (author), Goethem, F.V. (author), Vassallo, M. (author), Vinardell, P. (author), Zuang, V. (author), TNO Kwaliteit van Leven (author)
In spite of over 20 years of effort, no single in vitro assay has been developed and validated as a full regulatory replacement for the Draize Eye Irritation test. However, companies have been using in vitro methods to screen new formulations and in some cases as their primary assessment of eye irritation potential for many years. The present...
article 2010
document
Hueber-Becker, F. (author), Nohynek, G.J. (author), Meuling, W.J.A. (author), Benech-Kieffer, F. (author), Toutain, H. (author), TNO Voeding (author)
We investigated the absorption of a commercial [14C]-PPD- containing oxidative dark-shade hair dye in human volunteers as well as in vitro using human or pig ear skin. The hair of eight male volunteers was cut to a standard length, dyed, washed, dried, clipped and collected. Hair, washing water, materials used in the study and a 24-h scalp wash...
article 2004
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van der Meer, C. (author), Meeter, E. (author), Medisch Biologisch Laboratorium TNO (author)
article 1956
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Noltes, J.G. (author), Organisch chemisch instituut TNO (author)
article 1968
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Gusakov, A.V. (author), Sinitsyn, A.P. (author), Salanovich, T.N. (author), Bukhtojarov, F.E. (author), Markov, A.V. (author), Ustinov, B.B. (author), Zeijl, C.V. (author), Punt, P. (author), Burlingame, R. (author), TNO Kwaliteit van Leven (author)
Two forms of cellobiohydrolase I (CBH I, Cel7A) were purified from the culture ultrafiltrate of a mutant strain of the fungus Chrysosporium lucknowense, an industrial producer of cellulases and hemicellulases. The enzymes had different molecular masses (52 and 65 kDa, SDS-PAGE data) but the same pI (4.5). Peptide sequencing showed that a single...
article 2005
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Castro-Perez, J.M. (author), Kamphorst, J. (author), de Groot, J. (author), Lafeber, F. (author), Goshawk, J. (author), Yu, K. (author), Shockcor, J.P. (author), Vreeken, R.J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
A fast and robust method for lipid profiling utilizing liquid chromatography coupled with mass spectrometry has been demonstrated and validated for the analysis of human plasma. This method allowed quantification and identification of lipids in human plasma using parallel alternating low energy and high energy collision spectral acquisition...
article 2010
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de Lange, M. (author), de Geus, E.J.C. (author), Kluft, C. (author), Meijer, P. (author), van Doornen, L.J.P. (author), Boomsma, D.I. (author), Snieder, H. (author), TNO Kwaliteit van Leven (author)
Differences in genetic influence on death from CHD between males and females have been reported. Haemostatic factors have consistently been associated with risk for coronary heart disease (CHD), but sex differences in genetic architecture have not been studied. This study in middle-aged twins investigates whether there are sex differences in...
article 2006
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Wieringa, F.P. (author), Mastik, F. (author), Duncker, D.J.G.M. (author), Bogers, A.J.J.C. (author), van der Steen, A.F.W. (author), TNO Industrie en Techniek (author)
article 2006
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Franssen, G.C. (author)
article 2010
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Meeter, E. (author), Medisch Biologisch Laboratorium TNO (author)
article 1955
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Franken, A.C. (author), Christien Lokman, B. (author), Ram, A.F. (author), van den Hondel, C.A. (author), de Weert, S. (author), Punt, P.J. (author)
To increase knowledge on haem biosynthesis in filamentous fungi like Aspergillus niger, pathway-specific gene expression in response to haem and haem intermediates was analysed. This analysis showed that iron, 5′-aminolevulinic acid (ALA) and possibly haem control haem biosynthesis mostly via modulating expression of hemA [coding for 5′...
article 2012
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Besemer, A.C. (author), van Bekkum, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1994
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Schutte, J.B. (author), Pack, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1995
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Padró, T. (author), van den Hoogen, C.M. (author), Emeis, J.J. (author), Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
The aim of the present study was to investigate whether hypothyroidism would affect the components of the rat plasma fibrinolytic system. Hypothyroidism was induced by feeding rats a thiouracil-containing diet for 2 weeks. During this period, half of the animals received subcutaneous injections of L-thyroxine (20 μg/kg daily) to restore thyroid...
article 1993
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Zwart, A. (author), Arts, J.H.E. (author), ten Berge, W.F. (author), Appelman, L.M. (author)
A new design for acute inhalation toxicity testing was evaluated and compared with results obtained according to OECD guideline 403. The new design consists of a range-finding test, which is compatible with a conventional limit test, and can be followed by determination of a concentration-time-mortality relationship, enabling calculation of LC50...
article 1992
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Yuan, X.-L. (author), van der Kaaij, R.M. (author), van den Hondel, C.A.M.J.J. (author), Punt, P.J. (author), van der Maarel, M.J.E.C. (author), Dijkhuizen, L. (author), Ram, A.F.J. (author), TNO Kwaliteit van Leven (author)
The filamentous ascomycete Aspergillus niger is well known for its ability to produce a large variety of enzymes for the degradation of plant polysaccharide material. A major carbon and energy source for this soil fungus is starch, which can be degraded by the concerted action of α-amylase, glucoamylase and α-glucosidase enzymes, members of the...
article 2008
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Eikelboom, D.H. (author), Instituut voor Milieuhygiëne en Gezondheidstechniek TNO (author)
Approximately 1100 activated sludge samples, mostly derived from purification plants with bulking sludge, were investigated for the presence of filamentous organisms. Twenty six types were distinguished which are preliminarily classified into seven groups. The sheath forming Gram negative and Gram positive bacteria are classified into Groups I...
article 1975
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Reinhold, H.S. (author), Radiobiologisch Instituut TNO (author)
article 1981
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