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Su, L.C.J. (author), Bui, M. (author), Kardinaal, A. (author), Gomez-Aracena, J. (author), Martin-Moreno, J. (author), Martin, B. (author), Thamm, M. (author), Simonsen, N. (author), van 't Veer, P. (author), Kok, F. (author), Strain, S. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Biomarkers of dietary exposure or nutritional status are sought actively to overcome limitations of traditional dietary methodology. We compared plasma and adipose tissue biomarkers for carotenoids and tocopherols. The data consisted of samples from 91 men and 122 women, ages 45-70 years, from the control group of the European Community...article 1998
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Goldbohm, R.A. (author), Brants, H.A.M. (author), Hulshof, K.F.A.M. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This study presents data on dietary intake of specific carotenoids in the Netherlands, based on a recently developed food composition database for carotenoids. Regularly eaten vegetables, the main dietary source of carotenoids, were sampled comprehensively and analysed with modern analytic methods. The database was complemented with data from...article 1998
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Korst, A.E.C. (author), van der Sterre, M.L.T. (author), Gall, H.E. (author), Fichtinger-Schepman, A.M.J. (author), Vermorken, J.B. (author), van der Vijgh, W.J.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The pharmacokinetics of cisplatin was investigated in 13 patients receiving 18 courses of cisplatin alone or in combination with amifostine to investigate the influence of amifostine (WR 2721; Ethyol) on the pharmacokinetics of cisplatin. Cisplatin was administered as a 1-h i.v. infusion, whereas amifostine was given i.v. over 15 min just before...article 1998
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Klipstein-Grobusch, K. (author), den Breeijen, J.H. (author), Goldbohm, R.A. (author), Geleijnse, J.M. (author), Hofman, A. (author), Grobbee, D.E. (author), Witteman, J.C.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: The study was conducted to assess the relative validity of a 170-item semiquantitative food frequency questionnaire (SFFQ) adapted for use in the elderly. Design and subjects: The study was carried out in a sample of 80 men and women aged 55-75 y participating in a community based prospective cohort study in Rotterdam, The Netherlands...article 1998
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Simonsen, N. (author), van 't Veer, P. (author), Strain, J.J. (author), Martin-Moreno, J.M. (author), Huttunen, J.K. (author), Navajas, J.F.-C. (author), Martin, B.C. (author), Thamm, M. (author), Kardinaal, A.F.M. (author), Kok, F.J. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The fatty acid content of adipose tissue in postmenopausal breast cancer cases and controls from five European countries in the European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Cancer (EURAMIC) breast cancer study (1991-1992) was used to explore the hypothesis that fatty acids of the omega-3 family inhibit breast...article 1998
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van de Vijver, L.P.L. (author), Kardinaal, A.F.M. (author), van Duyvenvoorde, W. (author), Kruijssen, D.A.C.M. (author), Grobbee, D.E. (author), van Poppel, G. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)Accumulated evidence indicates that oxidative modification of LDL plays an important role in the atherogenic process. Therefore, we investigated the relation between coronary atherosclerosis and susceptibility of LDL to oxidation in a case-control study in men between 45 and 80 years of age. Case subjects and hospital control subjects were...article 1998
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Löwik, M.R.H. (author), Hulshof, K.F.A.M. (author), van der Heijden, L.J.M. (author), Brussaard, J.H. (author), Burema, J. (author), Kistemaker, C. (author), de Vries, P.J.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)From April 1987-March 1988, the first Dutch National Food Consumption Survey (DNFCS) was carried out among 2203 households comprising 5898 subjects, aged 1-85. In 1992 (January-December) the second DNFCS was conducted among 6218 subjects, aged 1-92 belonging to 2475 households. In both surveys, among other things, information on individual food...article 1998
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van Poppel, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Chemicals/CAS: Fatty Acidsarticle 1998
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van Ruseler- Embden, J.G.H. (author), van Lieshout, L.M.C. (author), Binnema, D.J. (author), Hazenberg, M.P. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)1. An earlier study by our group revealed that the viscosity of faeces from patients with Crohn's disease is significantly lower than that of healthy subjects. This is due to low concentrations of a high-molecular-mass carbohydrate, probably of bacterial origin. The cause of this phenomenon might be the impaired barrier function of the gut...article 1998
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Gizdulich, P. (author), Prentza, A. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)Objective: To model the pulse wave distortion and pressure decrement occurring between brachial and finger arteries. Distortion reversion and decrement correction were also our aims. Methods: Brachial artery pressure was recorded intra-arterially and finger pressure was recorded non-invasively by the Finapres technique in 53 adult human subjects...article 1997
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Hopman-Rock, M. (author), Odding, E. (author), Hofman, A. (author), Kraaimaat, F.W. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)Objective. To determine physical and psychosocial disability in subjects aged 55 to 74 years living in the community, in relation to pain in the hip and/or knee, and to explore the relationships between pain, physical and psychosocial disability, and selected background variables. Methods. A subsample from a community based study on pain,...article 1996
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Bots, M.L. (author), van der Bom, J.G. (author), Haverkate, F. (author), Meijer, P. (author), Hofman, A. (author), Grobbee, D.E. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)Background and objective. A low activated protein C (APC) response increases the risk of venous thrombosis, and possibly arterial disease. Apart from the factor V Leiden mutation, other factors may determine the level of APC response. In most studies on the association with arterial disease, cardiovascular risk factors were not appropriately...article 1996
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Hopman-Rock, M. (author), Kraaimaat, F.W. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)The relationship between the frequency (chronic, episodic, and sporadic) of arthritic pain in the hip and/or knee, other illness-related variables, physical disability, and a physically active lifestyle was analyzed in community-living subjects aged 55 to 74 years (N = 306). We tested the hypothesis that a physically active lifestyle is a...article 1996
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Biasucci, L.M. (author), de Maat, M.P.M. (author), Meo, A. (author), van der Greet, W. (author), Summaria, F. (author), Quaranta, G. (author), Liuzzo, G. (author), Kluft, C. (author), Maseri, A. (author), Gaubius Instituut TNO (author)In order to investigate the role of the hemostatic, fibrinolytic and inflammatory system in unstable angina, we assessed the levels of thrombin-antithrombin III (TAT), Prothrombin Fragment 1+2 (F1+2), plasmin-antiplasmin (PAP) and D-Dimer (DD) and of C-reactive protein (CRP) in 51 patients admitted to our CCU with severe unstable angina. Thirty...article 1996
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Heijmans, B.T. (author), Kluft, C. (author), Bots, M.L. (author), Lagaay, A.M. (author), Brand, A. (author), Grobbee, D.E. (author), Knook, D.L. (author), Slagboom, P.E. (author), Gaubius Instituut TNO (author)The genetic component of human longevity is estimated at 30%. Which genes are involved in determining human longevity, however, is largely unknown. Genes that may affect human survival are susceptibility loci for major age related pathologies. Many studies are being performed to identify such loci for cardiovascular disease, dementia and...article 1996
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Goldbohm, R.A. (author), van 't Veer, P. (author), van den Brandt, P.A. (author), van 't Hof, M.A. (author), Brants, H.A.M. (author), Sturmans, F. (author), Hermus, R.J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objectives: In studies on diet and cancer, diet assessment should address long-term intake. Therefore, the authors determined the 5-year reproducibility of a self-adminstered 150-item food frequency questionnaire (FFQ) used to assess dietary habits in the Netherlands Cohort Study on diet and cancer. Since the FFQ was repeated more than once, the...article 1995
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Kampman, E. (author), Verhoeven, D. (author), Sloots, L. (author), van 't Veer, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)To examine the relationship between colon cancer and food groups from vegetable or animal sources and their possible interactions with gender, we analyzed data from a Dutch case-control study. Dietary patterns were assessed for 232 colon cancer cases and 259 population controls. In multivariate analyses, the consumption of vegetables was...article 1995
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Davidse, W. (author), Perenboom, R.J.M. (author), TNO Preventie en Gezondheid (author)Objective. To increase the coverage of influenza vaccination by a programmatic approach in a large population, aimed at the general practitioners (GPs). Design. Intervention study (prospective). Setting. The region of central Brabant (Tilburg and some surrounding communities), the Netherlands. Method. The intervention was carried out in a...article 1995
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Grootenhuis, P.A. (author), Westenbrink, S. (author), Sie, C.M.T.L. (author), de Neeling, J.N.D. (author), Kok, F.J. (author), Bouter, L.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A self-administered semiquantitative food frequency questionnaire including 75 food items and providing information on the habitual intake of 31 nutritional parameters, based on the intake of protein, fat, carbohydrate, fiber and 11 vitamins and minerals, was developed for use in epidemiologic research on chronic disease among the elderly, such...article 1995
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Calculated iodine intake before and after simulated iodization (Dutch Nutrition Surveillance System)Brussaard, J.H. (author), Hulshof, K.F.A.M. (author), Löwik, M.R.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)To estimate the effect of possible goitre prophylactic measures on the intake of iodine among population groups, simulation studies, based on the first Dutch National Food Consumption Survey, were carried out. Iodine intake figures and prevalence of low intakes were calculated after fictively iodizing either bread, a combination of industrial...article 1995