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Ceridono, M. (author), Tellner, P. (author), Bauer, D. (author), Barroso, J. (author), Alépée, N. (author), Corvi, R. (author), de Smedt, A. (author), Fellows, M.D. (author), Gibbs, N.K. (author), Heisler, E. (author), Jacobs, A. (author), Jirova, D. (author), Jones, D. (author), Kandárová, H. (author), Kasper, P. (author), Akunda, J.K. (author), Krul, C. (author), Learn, D. (author), Liebsch, M. (author), Lynch, A.M. (author), Muster, W. (author), Nakamura, K. (author), Nash, J.F. (author), Pfannenbecker, U. (author), Phillips, G. (author), Robles, C. (author), Rogiers, V. (author), van de Water, F. (author), Liminga, U.W. (author), Vohr, H.W. (author), Wattrelos, O. (author), Woods, J. (author), Zuang, V. (author), Kreysa, J. (author), Wilcox, P. (author)This is the report from the “ECVAM–EFPIA workshop on 3T3 NRU Phototoxicity Test: Practical Experience and Implications for Phototoxicity Testing”, jointly organized by ECVAM and EFPIA and held on the 25–27 October 2010 in Somma Lombardo, Italy. The European Centre for the Validation of Alternative Methods (ECVAM) was established in 1991 within...article 2012
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Genkinger, J.M. (author), Li, R. (author), Spiegelman, D. (author), Anderson, K.E. (author), Albanes, D. (author), Bergkvist, L. (author), Bernstein, L. (author), Black, A. (author), van den Brandt, P.A. (author), English, D.R. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Giles, G.G. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Horn-Ross, P.L. (author), Jacobs, E.J. (author), Koushik, A. (author), Männisö, S. (author), Marshall, J.R. (author), Miller, A.B. (author), Patel, A.V. (author), Robien, K. (author), Rohan, T.E. (author), Schairer, C. (author), Stolzenberg-Solomon, R. (author), Wolk, A. (author), Ziegler, R.G. (author), Smith-Warner, S.A. (author)Background: Coffee has been hypothesized to have pro- and anticarcinogenic properties, whereas tea may contain anticarcinogenic compounds. Studies assessing coffee intake and pancreatic cancer risk have yielded mixed results, whereas findings for tea intake have mostly been null. Sugar-sweetened carbonated soft drink (SSB) intake has been...article 2012
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Jacobs, J.H. (author), Fuertes, E. (author), Krop, E.J.M. (author), Spithoven, J. (author), Tromp, P. (author), Heederik, D.J.J. (author)Objectives: To describe associations among swimming, respiratory health, allergen sensitisation and Clara cell protein 16 (CC16) levels in Dutch schoolchildren. Trichloramine levels in swimming pool air were determined to assess potential exposure levels. Methods: Respiratory health and pool attendance information was collected from 2359...article 2012
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Szymańska, E. (author), Bouwman, J. (author), Strassburg, K. (author), Vervoort, J. (author), Kangas, A.J. (author), Soininen, P. (author), Ala-Korpela, M. (author), Westerhuis, J. (author), van Duynhoven, J.P.M. (author), Mela, D.J. (author), MacDonald, I.A. (author), Vreeken, R.J. (author), Smilde, A.K. (author), Jacobs, D.M. (author)Obesity is a risk factor for cardiovascular diseases and type 2 diabetes especially when the fat is accumulated to central depots. Novel biomarkers are crucial to develop diagnostics for obesity and related metabolic disorders. We evaluated the associations between metabolite profiles (136 lipid components, 12 lipoprotein subclasses, 17 low...article 2012
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Erkens, S. (author), van Dommelen, A. (author), van Vliet, D. (author), Leegwater, G.A. (author), Jacobs, M. (author)In de shift-factor van 4 die wordt gebruikt in de Ontwerp Specificaties van Rijkswaterstaat zit onder andere het effect van de zelf-healing capaciteit van asfalt ten gevolge van rustperioden in de belasting die in de praktijk wel en in laboratorium proeven voor vermoeiing niet aanwezig zijn. De grootte van deze factor is bepaald aan de hand van...conference paper 2012
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Jacobs, P. (author)Dit artikel geeft de resultaten weer van een monitoringsonderzoek in 64 nieuwbouwwoningen. Uit dit onderzoek blijkt dat het raamgebruik sterk is gecorreleerd met de buitentemperatuur. De resultaten suggereren dat zelfs in het stookseizoen de temperatuur van de slaapkamers te hoog wordt ervaren. Met de huidige woning- en installatieconcepten...article 2012
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- Jacobs, P. (author), Voogt, M.H. (author), Vons, V.A. (author) report 2012
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Jacobs, P. (author), Broek, R. (author), Vons, V. (author)Voldoende frisse lucht in gebouwen is belangrfk. Professionals in de gezondheidszorg adviseren ventilatie om bijvoorbeeld luchtwegklachten te verminderen. Tevens is aangetoond dat productiviteit en welbevinden bevorderd worden naarmate ervoldoende frisse tucht aanwezig is. Maar zomaar buitenlucht direct naar binnen blazen om te ventileren kan in...article 2012
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- Moors, E.J. (author), Dolman, H. (author), Elbers, J. (author), Hensen, A. (author), Duyzer, J.H. (author), Kroon, P.S. (author), Veenendaal, E.M. (author), van Huissteden, J. (author), Bosveld, F. (author), Jacobs, C. (author), Jans, W. (author), Kuikman, P. (author), Nol, L. (author), van Beek, C. (author) report 2012
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Jacobs, P.L. (author), Ridder, L. (author), Ruijken, M. (author), Rosing, H. (author), Jager, N.G.L. (author), Beijnen, J.H. (author), Bas, R.R. (author), van Dongen, W.D. (author), TNO Triskelion BV (author)Background: Comprehensive identification of human drug metabolites in first-in-man studies is crucial to avoid delays in later stages of drug development. We developed an efficient workflow for systematic identification of human metabolites in plasma or serum that combines metabolite prediction, high-resolution accurate mass LC-MS and MS vendor...article 2013
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Martijn, L.L.M. (author), Jacobs, A.J.E. (author), Maassen, I.I.M. (author), Buitendijk, S.S.E. (author), Wensing, M.M. (author)Objective: to describe the incidence and characteristics of patient safety incidents in midwifery-led care for low-risk pregnant women. Design: multi-method study. Setting: 20 midwifery practices in the Netherlands; 1,000 patient records. Population: low-risk pregnant women. Methods: prospective incident reporting by midwives during 2 weeks;...article 2013
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Assessment of inflammatory resilience in healthy subjects using dietary lipid and glucose challengesWopereis, S. (author), Wolvers, D. (author), van Erk, M.J. (author), Gribnau, M. (author), Kremer, S.H.A. (author), van Dorsten, F.A. (author), Boelsma, E. (author), Garczarek, U. (author), Cnubben, N. (author), Frenken, L. (author), der Logt P, van (author), Hendriks, H.F. (author), Albers, R. (author), van Duynhoven, J. (author), van Ommen, B. (author), Jacobs, D.M. (author)Background: Resilience or the ability of our body to cope with daily-life challenges has been proposed as a new definition of health, with restoration of homeostasis as target resultant of various physiological stress responses. Challenge models may thus be a sensitive measure to study the body’s health. The objective of this study was to select...article 2013
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Santoro, A. (author), Pini, E. (author), Scurti, M. (author), Palmas, G. (author), Berendsen, A. (author), Brzozowska, A. (author), Pietruszka, B. (author), Szczecinska, A. (author), Cano, N. (author), Meunier, N. (author), de Groot, C.P.G.M. (author), Feskens, E. (author), Fairweather-Tait, S. (author), Salvioli, S. (author), Capri, M. (author), Brigidi, P. (author), Franceschi, C. (author), Fabbri, C. (author), Bertarelli, C. (author), Izzi, M. (author), Mazzocchi, M. (author), Chardigny, J.M. (author), Morio, B. (author), Rossi, D. (author), Notarfonso, M. (author), O'Toole, P.W. (author), Cashman, K. (author), Carding, S.R. (author), Nicoletti, C. (author), Jacobs, D. (author), Xipsiti, M. (author), Fernandez, L. (author), Wills, J. (author), Irz, X. (author), Kuosmanen, N. (author), Gonos, E.S. (author), Voutetakis, K. (author), Salmon, M. (author), Toussaint, O. (author), Traill, B.W. (author), Nocella, G. (author), Caracciolo, B. (author), Xu, W. (author), Ikonen, M. (author), Tuure, T. (author), Brummer, R. (author), Kadi, F. (author), Breton, S. (author), Triomphe, M. (author), Magario, G. (author), Villani, F. (author), Pancrazio, A. (author), Teufner, B. (author), Stocker, J. (author), Echevarría, F.J. (author), Iglesias, J.R. (author), Smrž, F. (author), Krejcirova, L. (author), Koytsomitropoulou, E. (author), Georgakidis, K. (author), Yornuk, R. (author), Ucar, C. (author), van Ommen, B. (author), Bouwman, J. (author), Collino, S. (author), Jankovics, C. (author), Losó, A. (author), de Vos, W. (author), Fuentes, S. (author), Commelin, E. (author)The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale...article 2014
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Jacobs, P. (author)De Vereniging Leveranciers van Luchttechnische Apparaten (VLA) heeft samen met TNO een uniek meetprotocol ontwikkeld. Dit protocol geeft met behulp van optische deeltjes-tellers een schatting voor de jaargemiddelde fijnstofconcentratie in kantoorruimtes. Met de uitkomsten van zo'n meting kan worden afgewogen of filters en/of...article 2014
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Jacobs, P. (author)De aanpak van het binnenklimaat bij scholen beperkt zich meestal tot ventilatie en temperatuurbeheersing. Fijnstof krijgt - onterecht - weinig aandacht. De concentratie PM10 fijnstof is juist in scholen bijzonder hoog, veel hoger zelfs dan buiten. De ramen open zetten voor'frisse lucht' is niet altijd verstandig. Met de frisse lucht komen...article 2014
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Jacobs, P. (author), Voogt, M.H. (author)TNO heeft begin dit jaar samen met de VLA een meetprotocol voor de bepaling van fijnstof (PM2.5) ontwikkeld. Het protocol beschrijft hoe met optische deeltjestellers op basis van een week meten een schatting voor de jaargemiddelde fijnstofconcentratie in kantoorruimten kan worden gemaakt. Met de uitkomsten van zo'n meting is de afweging...article 2014
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Jacobs, P. (author), Phaff, J.C. (author), Voogt, M.H. (author)An intervention study with a decentral electrostatic filter has been carried out in a nursery. The field study shows that it is possible to reach a reduction up to 80% of ultra-fine (<0.1 μm) and up to 68% for the PM1 and PM2,5-PM1 fractions at a relatively low energy consumption. These particle fractions were mostly determined by the outdoor...conference paper 2014
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Jacobs, P. (author), Kornaat, W. (author)Mechanische ventilatie met warmteterugwinning (WTW) levert volgens de in deze studie gehanteerde uitgangspunten in bestaande schoolgebouwen een relatief kleine besparing op. Bij nieuwbouw kan WIW op scholen zelfs voor een verhoging van de energiekosten zorgen, afhankelijk van de benodigde ventilatorenergie. ln de steeds beter geïsoleerde scholen...article 2014
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Mihaleva, V.V. (author), van Schalkwijk, D.B. (author), de Graaf, A.A. (author), van Duynhoven, J. (author), van Dorsten, F.A. (author), Vervoort, J. (author), Smilde, A. (author), Westerhuis, J.A. (author), Jacobs, D.M. (author)A systematic approach is described for building validated PLS models that predict cholesterol and triglyceride concentrations in lipoprotein subclasses in fasting serum from a normolipidemic, healthy population. The PLS models were built on diffusion-edited 1H NMR spectra and calibrated on HPLC-derived lipoprotein subclasses. The PLS models were...article 2014
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Scholten, J.E. (author), Jacobs, P. (author), Goes, R. (author), Kamerbeek, S. (author)Gaswarmtepompen zorgen voor een efficiënt gebruik van fossiele energie en het ontlasten van het elektriciteitsnet. Dit artikel gaat in op de verschillende varianten van gaswarmtepompen en beschrijft kort een aantal praktijk cases. Vooral toepassingen waarbij het gehele jaar gelijktijdig wordt verwarmd en gekoeld, zoals in ziekenhuizen en in...article 2014