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de Vogel, S. (author), Dindore, V. (author), van Engeland, M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)
Adequate intake of folate, methionine, riboflavin, and vitamin B-6 may prevent aberrant DNA methylation and thereby protect against colorectal cancer (CRC). However, previous epidemiological studies investigating associations between dietary intakes of these nutrients and CRC have been inconsistent. We investigated the associations between...
article 2008
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van der Ploeg, C.P.B. (author), Lanting, C.I. (author), Verkerk, P.H. (author), TNO Kwaliteit van Leven (author)
article 2008
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Keijser, B.J.F. (author), Zaura, E. (author), Huse, S.M. (author), van der Vossen, J.M.B.M. (author), Schuren, F.H.J. (author), Montijn, R.C. (author), ten Gate, J.M. (author), Crielaard, W. (author), TNO Kwaliteit van Leven (author)
A good definition of commensal microflora and an understanding of its relation to health are essential in preventing and combating disease. We hypothesized that the species richness of human oral microflora is underestimated. Saliva and supragingival plaque were sampled from 71 and 98 healthy adults, respectively. Amplieons from the V6...
article 2008
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Martens, M.K. (author), van Assema, P. (author), Paulussen, T.G.W.M. (author), van Breukelen, G. (author), Brug, J. (author), TNO Kwaliteit van Leven (author)
Objective: The aim of this study was to assess the behavioural effects of a school-based healthful diet promotion intervention implemented in lower vocational schools. Design: A cluster-randomised pre-test-post-test experimental design was used, and data were collected by means of written questionnaires. Setting: Students of 18 Dutch lower...
article 2008
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Hogervorst, J.G.F. (author), Schouten, L.J. (author), Konings, E.J.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Acrylamide is a probable human carcinogen that was detected in several heat-treated foods, such as French fries and crisps, in 2002. Prospective studies are needed on acrylamide and human cancer risk. We prospectively investigated the association between acrylamide and gastrointestinal cancer risk. In 1986, 120,852 men and women (aged 55-69 y)...
article 2008
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Dekking, E.H.A. (author), van Veelen, P.A. (author), de Ru, A. (author), Kooy-Winkelaar, E.M.C. (author), Gröneveld, T. (author), Nieuwenhuizen, W.F. (author), Koning, F. (author), TNO Kwaliteit van Leven (author)
Celiac disease (CD) is a permanent intolerance to gluten. In CD patients, gluten peptides cause an inflammation in the small intestine leading to tissue damage. Tissue transglutaminase (tTG) is an enzyme involved in the repair of damaged tissue by crosslinking of extracellular matrix proteins. Under certain conditions, tTG can deamidate...
article 2008
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van Boxtel, E.L. (author), van den Broek, L.A.M. (author), Koppelman, S.J. (author), Gruppen, H. (author), TNO Kwaliteit van Leven (author)
Legumin proteins Ara h 3 from peanuts and glycinin from soybeans are increasingly described as important allergens. The stability of an allergen's IgE binding capacity towards heating and digestion is considered an important characteristic for food allergens. We investigated the effects of heating and digestion on the IgE binding of Ara h 3 and...
article 2008
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IJmker, S. (author), Mikkers, J. (author), Blatter, B.M. (author), van der Beek, A.J. (author), van Mechelen, W. (author), Bongers, P.M. (author), TNO Kwaliteit van Leven (author)
Introduction: "Ergonomic" questionnaires are widely used in epidemiological field studies to study the association between workstation characteristics, work posture and musculoskeletal disorders among office workers. Findings have been inconsistent regarding the putative adverse effect of work postures. Underestimation of the true association...
article 2008
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Eijkemans, M. (author), Mommers, M. (author), de Vries, S.I. (author), van Buuren, S. (author), Stafleu, A. (author), Bakker, I. (author), Thijs, C. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE. Prevalence of asthma and overweight has increased simultaneously during the past decades. Several studies have reported an association between these two health problems, but it is unclear whether this relation is causal. We hypothesize that children with asthmatic symptoms are less physically active, which may contribute to the...
article 2008
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Brenninkmeijer, V. (author), Houtman, I. (author), Blonk, R. (author), TNO Kwaliteit van Leven (author)
Background: The World Health Organization considers depression a major health problem and a leading cause of disability. Aim To identify factors which may help to reduce depressive symptoms in a sample of employees sick listed due to mental health problems. Methods: Longitudinal cohort study of employees sick listed for 12-20 weeks due to mental...
article 2008
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Hille, E.T.M. (author), Dorrepaal, C. (author), Perenboom, R. (author), Gravenhorst, J.B. (author), Brand, R. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)
Objective: To assess social lifestyle, risk-taking behavior, and psychopathology in young adults born very preterm or with a very low birthweight. Study design: This study was part of the 19-year follow-up in a large ongoing collaborative study in the Netherlands (the POPS study) on the long-term outcome of prematurity and dysmaturity. 656...
article 2008
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Kaptein, S. (author), Jansen, D.E.M.C. (author), Vogels, A.G.C. (author), Reijneveld, S.A. (author), TNO Kwaliteit van Leven (author)
Background: The assessment of mental health problems in children with intellectual disability (ID) mostly occurs by filling out long questionnaires that are not always validated for children without ID. The aim of this study is to assess the differences in mental health problems between children with ID and without ID, using a short...
article 2008
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Dijkman, A. (author), TNO Kwaliteit van Leven (author)
Een gemiddeld ziekteverzuimpercentage tussen vier en vijf procent is niet meer de eerste aanleiding voor werkgevers om te investeren in gezondheid van medewerkers. Maar om in deze turbulente tijden productief en innovatief te blijven, zijn er veel redenen waarom werkgevers dat eigenlijk wél moeten doen!
article 2008
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van Buuren, S. (author)
article 2008
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Kocken, P.L. (author), Zwanenburg, E.J.-v. (author), de Hoop, T. (author), TNO Kwaliteit van Leven (author)
Objective: : The effectiveness of use of migrant health educators in the general practitioners' care for female migrants with psychosomatic problems was evaluated to contribute to the improvement of the care for these patients. Methods: : A randomised controlled trial (RCT) design was used. A total of 104 patients (75%) agreed to take part in...
article 2008
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Boomsma, D.I. (author), Willemsen, G. (author), Sullivan, P.F. (author), Heutink, P. (author), Meijer, P. (author), Sondervan, D. (author), Kluft, C. (author), Smit, G. (author), Nolen, W.A. (author), Zitman, F.G. (author), Smit, J.H. (author), Hoogendijk, W.J. (author), van Dyck, R. (author), de Geus, E.J.C. (author), Penninx, B.W.J.H. (author), TNO Kwaliteit van Leven (author)
To identify the genomic regions that confer risk and protection for major depressive disorder (MDD) in humans, large-scale studies are needed. Such studies should collect multiple phenotypes, DNA, and ideally, biological material that allows gene expression analysis, transcriptomic, proteomic, and metabolomic studies. In this paper, we briefly...
article 2008
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Shin, D. (author), Curits, M. (author), Huisingh, D. (author), Zwetsloot, G.I. (author), TNO Kwaliteit van Leven (author)
This paper is based upon the understanding that fundamental disciplines of human knowledge such as chemistry, ecology, sociology, geology, economics, engineering or politics, cannot, by themselves, provide the sufficient and necessary solutions to complex problems of sustainability. The paper, therefore, presents an integrated knowledge approach...
article 2008
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Vogels, A.G.C. (author), Jacobusse, G.W. (author), Hoekstra, F. (author), Brugman, E. (author), Crone, M. (author), Reijneveld, S.A. (author), TNO Kwaliteit van Leven (author)
Objective: To assess whether differences between individual Preventive Child Health Care (PCH) professionals in the percentage of children they identify as having psychosocial problems are larger than expected based on chance and whether such differences can be explained by differences in parent-reported problems or risk indicators. Study Design...
article 2008
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Ganzevles, R.A. (author), Fokkink, R. (author), van Vliet, T. (author), Cohen Stuart, M.A. (author), de Jongh, H.H.J. (author), TNO Kwaliteit van Leven (author)
Based on earlier reported surface rheological behaviour two factors appeared to be important for the functional behaviour of mixed protein/polysaccharide adsorbed layers at air/water interfaces: (1) protein/polysaccharide mixing ratio and (2) formation history of the layers. In this study complexes of β-lactoglobulin (positively charged at pH 4...
article 2008
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van Peppen, R.P.S. (author), Maissan, F.J.F. (author), van Genderen, F.R. (author), van Dolder, R. (author), van Meeteren, N.L.U. (author), TNO Kwaliteit van Leven (author)
Objective. To investigate physiotherapists' self-reported use of outcome measures as recommended in the Dutch Clinical Practice Guideline on Physiotherapy Management of Patients with Stroke (CPGPS) and to assess perceived barriers to and facilitators for the use of outcome measures in everyday practice. Method. A 41-item survey, including the...
article 2008
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