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Rubbens, M.P. (author), Mol, A. (author), Boerboom, R.A. (author), Bank, R.A. (author), Baaijens, F.P.T. (author), Bouten, C.V.C. (author), TNO Industrie en Techniek TNO Kwaliteit van Leven (author)
Tissue-engineered heart valves lack sufficient amounts of functionally organized structures and consequently do not meet in vivo mechanical demands. To optimize tissue architecture and hence improve mechanical properties, various in vitro mechanical conditioning protocols have been proposed, of which intermittent straining is most promising in...
article 2009
document
Hissink, A.M. (author), Krüse, J. (author), Kulig, B.M. (author), Verwei, M. (author), Muijser, H. (author), Salmon, F. (author), Leenheers, L.H. (author), Owen, D.E. (author), Lammers, J.H.C.M. (author), Freidig, A.P. (author), McKee, R.H. (author), TNO Kwaliteit van Leven (author)
As part of a project designed to develop a framework for extrapolating acute central nervous system (CNS) effects of hydrocarbon solvents in animals to humans, experimental studies were conducted in rats and human volunteers in which acute CNS effects were measured and toxicokinetic data were collected. A complex hydrocarbon solvent, white...
article 2007
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Lewis, D.F.V. (author), Lake, B.G. (author), TNO Voeding (author)
article 2002
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Havenith, G. (author), Luttikholt, V.G.M. (author), Vrijkotte, T.G.M. (author)
The present study was designed to determine the relative importance of individual characteristics such as maximal oxygen uptake (V_O2 max), adiposity, DuBois body surface area (AD), surface to mass ratio (AD:mass) and body mass, for the individ-ual's reaction to humid heat stress. For this purpose 27 subjects (19 men, 8 women),eterogeneous...
article 1995
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Bol, J. (author), Huis in 't Veld, J.H.J. (author), Centraal instituut voor voedingsonderzoek TNO (author)
Fermentatieve processen worden reeds eeuwenlang gebruikt in de voedings- en genotmiddelenindustrie. Reeds 3000 jaar voor Christus werden door Chinezen uit rijstprodukten langs fermentatieve weg bereid. De Assyriërs hadden reeds 2000 jaar voor Christus een bloeiende wijncultuur. De kennis van deze processen werd empirisch van generatie op...
article 1986
document
Kuper, C.F. (author), Bosland, M.C. (author)
article 2019
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ter Beek, A. (author), Keijser, B.J.F. (author), Boorsma, A. (author), Zakrzewska, A. (author), Orij, R. (author), Smits, G.J. (author), Brul, S. (author), TNO Kwaliteit van Leven (author)
The weak organic acid sorbic acid is a commonly used food preservative, as it inhibits the growth of bacteria, yeasts, and molds. We have used genome-wide transcriptional profiling of Bacillus subtilis cells during mild sorbic acid stress to reveal the growth-inhibitory activity of this preservative and to identify potential resistance...
article 2008
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Coulier, L. (author), Bradley, E.L. (author), Bas, R.C. (author), Verhoeckx, K.C.M. (author), Driffield, M. (author), Harmer, N. (author), Castle, L. (author), TNO Kwaliteit van Leven (author)
Bisphenol A diglycidyl ether (BADGE) is an epoxide that is used as a starting substance in the manufacture of can coatings for food-contact applications. Following migration from the can coating into food, BADGE levels decay and new reaction products are formed by reaction with food ingredients. The significant decay of BADGE was demonstrated by...
article 2010
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Brocades Zaalberg, O. (author), Medisch Biologisch Laboratorium TNO (author)
article 1966
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van Duuren, J.B.J.H. (author), Wijte, D. (author), Leprince, A. (author), Karge, B. (author), Puchalka, J. (author), Wery, J. (author), Dos Santos, V.A.P.M. (author), Eggink, G. (author), Mars, A.E. (author)
Pseudomonas putida KT2440-JD1 was derived from P. putida KT2440 after N-methyl-N'-nitro-N-nitrosoguanidine (NTG)-mutagenesis and exposure to 3-fluorobenzoate (3-FB). The mutant was no longer able to grow using benzoate as a sole carbon source, but co-metabolized benzoate to cis, cis-muconate during growth on glucose, which accumulated in the...
article 2011
document
Kuper, C.F. (author), van Zijverden, M. (author), Klaassen, C. (author), Tegelenbosch-Schouten, M. (author), Wolterbeek, A.P.M. (author), TNO Kwaliteit van Leven (author)
The effects of cyclosporin A (CY) and cyclophosphamide (CPS) on Peyer's patches (PP) were studied in Wistar rats, exposed in utero and neonatally or during adult age. In one study, pregnant dams received 5 or 15 mg/kg bw/day CY from gestation day 6 to day 21 of lactation. In two other studies, animals were exposed at young adult age: female rats...
article 2007
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van der Waaij, D. (author), van Bekkum, D.W. (author), Radiobiologisch Instituut (author)
article 1965
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van der Bom, J.G. (author), Bots, M.L. (author), Haverkate, F. (author), Meijer, P. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
Objective: We studied the association of plasma concentrations of tissuetype plasminogen activator (t-PA) and the, until now single documented polymorphism of the t-PA gene, with degree of atherosclerosis and the prevalence of myocardial infarction. Design: Cross-sectional, population-based case control study. Setting: A district of Rotterdam,...
article 1996
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Jenks, R.L. (author), Astrup, T. (author), Gaubius instituut TNO (author)
Treatment of human citrated plasma with glass has complex effects on the fibrinolytic system. While the spontaneous euglobulin activity is only slightly affected by the glass treatment, the activity precipitated in the presence of dextran sulphate diminishes rapidly with increasing amounts of glass. With common glass a minimum is reached, and...
article 1980
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van Vliet, A.K. (author), van Thiel, G.C.F. (author), Naaktgeboren, N. (author), Cohen, L.H. (author), Gaubius Instituut TNO (author)
Lovastatin and simvastatin are strong inhibitors of cholesterol synthesis in cultured human granulosa cells, as measured within 6 days after isolation, with IC50-values of respectively 27.0 and 18.2 nM obtained after 3.5 hours of incubation with the drugs. Pravastatin is a much weaker inhibitor of cholesterol synthesis (IC50-value of 977.8 nM)...
article 1996
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van Noort, J.M. (author), van Sechel, A.C. (author), Bajramovic, J.J. (author), El Quagmiri, M. (author), Polman, C.H. (author), Lassmann, H. (author), Ravid, R. (author), TNO Preventie en Gezondheid (author)
The identification of key antigens in human autoimmune diseases is a crucial step towards the development of specific intervention. The autoantigen(s) relevant to multiple sclerosis (MS) probably reside in myelin of the central nervous system, the target of the disease. Here we examine proliferative responses of human peripheral blood T cells to...
article 1995
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Cobb, Z. (author), de Vries, R. (author), Spooner, N. (author), Williams, S. (author), Staelens, L. (author), Doig, M. (author), Broadhurst, R. (author), Barfield, M. (author), van de Merbel, N. (author), Schmid, B. (author), Siethoff, C. (author), Ortiz, J. (author), Verheij, E. (author), van Baar, B. (author), White, S. (author), Timmerman, P. (author)
Background: At the start of their work, the European Bioanalysis Forum dried blood spots microsampling consortium did not form a dedicated team to investigate the spot homogeneity. However, two teams performed experiments that produced results relating to sample homogeneity. Results: The data, which were produced via two different approaches (a...
article 2013
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Rijken, D.C. (author), Groeneveld, E. (author), Barrett-Bergshoeff, M.M. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
BM 06.022 is a non-glycosylated mutant of human tissue-type plasminogen activator (t-PA) comprising only the kringle-2 and proteinase domains. The in vivo half-life of BM 06.022 antigen is 4- to 5-fold longer than that of t-PA antigen. The in vitro half-life of the activity of BM 06.022 at therapeutic concentrations in plasma is shorter than...
article 1994
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Binnema, D.J. (author), Dooijewaard, G. (author), van Iersel, J.J.L. (author), Turion, P.N.C. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
Apart from tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), a third PA appears to occur in human plasma. Its activity is initiated when appropriate triggers of the contact system are added, and the activation depends on the presence of factor XII and prekallikrein in plasma. The activity of this, so...
article 1990
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Haverkate, F. (author), Samama, M. (author), TNO Preventie en Gezondheid (author)
Approximately 250 cases of dysfibrinogenemia have been reported; 55% were asymptomatic (detected by chance), 25% had a tendency to bleeding, and 20% were reported to have a tendency to thrombosis. To establish a possible association between familial dysfibrinogenemia and thrombophilia, data on cases with both affections were collected in a study...
article 1995
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