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Schuurman, A.G. (author), Goldbohm, R.A. (author), Dorant, E. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In the Netherlands Cohort Study, the authors investigated whether anthropometry is associated with prostate cancer risk. At baseline in 1986, 58,279 men aged 55-69 years completed a self- administered questionnaire on diet, anthropometry, and other risk factors for cancer. After 6.3 years of follow-up, 681 cases were available with complete data...article 2000
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Westhoff, M.H. (author), Stemmerik, L. (author), Boshuizen, H.C. (author), TNO Preventie en Gezondheid (author)This study's purpose was to investigate whether a 10-week low-intensity strength-training program could improve strength of the knee extensors and functional ability. Participants 65 years and older with low knee-extensor muscle strength were randomized into an exercise (n = 11) and a control group (n = 10). Knee-extensor strength and functional...article 2000
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Sprangers, M.A.G. (author), de Regt, E.B. (author), Andries, F. (author), van Agt, H.M.E. (author), Bijl, R.V. (author), de Boer, J.B. (author), Foets, M. (author), Hoeymans, N. (author), Jacobs, A.E. (author), Kempen, G.I.J.M. (author), Miedema, H.S. (author), Tijhuis, M.A.R. (author), de Haes, H.C.J.M. (author), NIA TNO (author)The objective of the present study is to compare the QL of a wide range of chronic disease patients. Secondary analysis of eight existing data sets, including over 15,000 patients, was performed. The studies were conducted between 1993 and 1996 and included population-based samples, referred samples, consecutive samples, and/or consecutive...article 2000
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Bemelmans, W.J.E. (author), Broer, J. (author), de Vries, J.H.M. (author), Hulshof, K.F.A.M. (author), May, J.F. (author), Meyboom-de Jong, B. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To investigate the impact of intensive group education on the Mediterranean diet on dietary intake and serum total cholesterol after 16 and 52 weeks, compared to a posted leaflet with the Dutch nutritional guidelines, in the context of primary prevention of cardiovascular disease (CVD). Design: Controlled comparison study of an...article 2000
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Botterweck, A.A.M. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)BACKGROUND. Numerous components of fruit and vegetables are considered to decrease the risk of gastric carcinoma. In the current prospective study, the authors examined the association between the intake of vitamins, carotenoids, and dietary fiber and vitamin supplement use and the incidence rate of gastric carcinoma. METHODS. The Netherlands...article 2000
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Botterweck, A.A.M. (author), Verhagen, H. (author), Goldbohm, R.A. (author), Kleinjans, J. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Both carcinogenic and anticarcinogenic properties have been reported for the synthetic antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). The association between dietary intake of BHA and BHT and stomach cancer risk was investigated in the Netherlands Cohort Study (NLCS) that started in 1986 among 120,852 men and...article 2000
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Bajramović, J.J. (author), Bsibsi, M. (author), Geutskens, S.B. (author), Hassankhan, R. (author), Verhulst, K.C. (author), Stege, G.J.J. (author), de Groot, C.J.A. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)Various lines of evidence suggest a close relationship between heat shock proteins (hsp) and several autoimmune diseases such as arthritis, diabetes and multiple sclerosis. While enhanced expression of hsp in autoimmune diseases is often regarded as a non-specific bystander effect of the inflammatory process, surprisingly little is known on hsp...article 2000
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Voorrips, L.E. (author), Goldbohm, R.A. (author), van Poppel, G. (author), Sturmans, F. (author), Hermus, R.J.J. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The relation between vegetable and fruit consumption and colorectal cancer risk was comprehensively assessed in the Netherlands Cohort Study on Diet and Cancer using a validated 150-item food frequency questionnaire. After 6.3 years of follow-up (1986-1992), over 1,000 incident cases of colorectal cancer were registered. Using case-cohort...article 2000
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van den Heuvel, E.G.H.M. (author), Schoterman, M.H.C. (author), Muijs, T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The aim of this study was to investigate whether a product rich in transgalactooligosaccharides (TOS, Elix'or) stimulates true Ca absorption in postmenopausal women. The study was a double-blind, randomized crossover study, consisting of two 9-d treatment periods separated by a 19-d washout period. During the treatment periods, 12 subjects drank...article 2000
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Kampman, E. (author), Voskuil, D.W. (author), van Kraats, A.A. (author), Balder, H.F. (author), van Muijen, G.N.P. (author), Goldbohm, R.A. (author), van 't Veer, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)K-ras gene mutations (codons 12 and 13) were determined by PCR-based mutant allele-specific amplification (MASA) in tumour tissue of 185 colon cancer patients: 36% harboured mutations, of which 82% were located in codon 12. High intakes of animal protein, calcium and poultry were differently associated with codon 12 and 13 mutations: odds ratios...article 2000
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van den Brandt, P.A. (author), Spiegelman, D. (author), Yaun, S-S. (author), Adami, H-O. (author), Beeson, L. (author), Folsom, A.R. (author), Fraser, G. (author), Goldbohm, R.A. (author), Graham, S. (author), Kushi, L. (author), Marshall, J.R. (author), Miller, A.B. (author), Rohan, T. (author), Smith-Warner, S.A. (author), Speizer, F.E. (author), Willett, W.C. (author), Wolk, A. (author), Hunter, D.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. In multivariate analyses controlling for reproductive, dietary, and other risk factors, the pooled...article 2000
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Department of Pharmacology (author), Langeveld-Wildschut, E.G. (author), Riedl, H. (author), Thepen, T. (author), Bihari, I.C. (author), Bruijnzeel, P.L.B. (author), Bruijnzeel-Koomen, C.A.F.M. (author)Background: Pharmacologic studies in atopic eczema (AE) are difficult to standardize. Patients with AE differ in the stage of their skin disease (acute, subacute, chronic). Objective: This study was designed to assess macroscopic and microscopic effects of pretreatment with topical glucocortico-steroids (GCSs) and tar on the atopy patch test ...article 2000
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Gaubius Instituut TNO (author), Verzijl, N. (author), de Groot, J. (author), Thorpe, S.R. (author), Bank, R.A. (author), Shaw, J.N. (author), Lyons, T.J. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), Baynes, J.W. (author), TeKoppele, J.M. (author)Collagen molecules in articular cartilage have an exceptionally long lifetime, which makes them susceptible to the accumulation of advanced glycation end products (AGEs). In fact, in comparison to other collagen-rich tissues, articular cartilage contains relatively high amounts of the AGE pentosidine. To test the hypothesis that this higher AGE...article 2000
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Voskuil, D.W. (author), Kampman, E. (author), van Kraats, A.A. (author), Balder, H.F. (author), van Muijen, G.N.P. (author), Goldbohm, R.A. (author), van 't Veer, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Epidemiological studies have suggested that dietary factors may differently affect p53-dependent and p53-independent pathways to colon cancer. Results of such studies may depend on the method used to assess p53 status. This case-control study of 185 colon-cancer cases and 259 controls examines this relation, using both immunohistochemistry and...article 1999
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Schuurman, A.G. (author), Zeegers, M.P.A. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)We investigated the risk of prostate cancer in relation to a family history of prostate cancer in 58,279 men ages 55-69 years. We found 704 incident cases after 6.3 years of follow-up. Rate ratios and 95% confidence intervals for having an affected vs nonaffected father and brother were, respectively 1.44 (0.80-2.58) and 5.57 (1.61-19.26). We...article 1999
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Schuurman, A.G. (author), van den Brandt, P.A. (author), Dorant, E. (author), Brants, H.A.M. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)BACKGROUND. The roles of energy and fat intake as risk factors for prostate carcinoma are still questionable. Therefore, these factors were evaluated in the Netherlands Cohort Study described in this article.article 1999
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van de Vijver, L.P.L. (author), Kardinaal, A.F.M. (author), van Duyvenvoorde, W. (author), Kruijssen, D.A.C.M. (author), Grobbee, D.E. (author), van Poppel, G. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years of age. The ankle-arm index was calculated for...article 1999
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Dirx, M.J.M. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Lumey, L.H. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Objectives: In The Netherlands, part of the population experienced food restriction and severe famine during World War II. The purpose of this study was to study the effects of severe undernutrition during adolescence on the risk of breast cancer later in life. Methods: We examined the hypothesis in the Netherlands Cohort Study on diet and...article 1999
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), Schuurman, A.G. (author), van den Brandt, P.A. (author), Dorant, E. (author), Goldbohm, R.A. (author)Prostate cancer risk in relation to consumption of animal products, and intake of calcium and protein was investigated in the Netherlands Cohort Study. At baseline in 1986, 58,279 men aged 55-69 years completed a self-administered 150-item food frequency questionnaire and a questionnaire on other risk factors for cancer. After 6.3 years of...article 1999
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Botterweck, A.A.M. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The association between vegetable and fruit consumption and stomach cancer risk was investigated in the Netherlands Cohort Study among 120,852 men and women aged 55-69 years at the start in September 1986. Analyses were based on 282 incident stomach cancer cases after 6.3 years of follow-up. Age- and sex-adjusted rate ratios of stomach cancer in...article 1998