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Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Although obesity is an established risk factor for endometrial cancer, evidence linking risk to height, weight change since age 20, and physical activity is limited. In this case-cohort study, 62 573 women from The Netherlands Cohort Study on Diet and Cancer were followed up from 1986 to 1995, and 226 endometrial cancer case patients were...article 2004
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Boere-Boonekamp, M.M. (author), L'Hoir, M.P. (author), Beltman, M. (author), Bruil, J. (author), Dijkstra, N. (author), Engelberts, A.C. (author), TNO Kwaliteit van Leven (author)Objective. Description of unhealthy behaviour and views regarding nutrition, physical exercise and education in families with young children, in relation to specific groups with a high risk of overweight. Design. Cross-sectional study. Method. In wellbaby clinics for infants and toddlers in various sites in the Netherlands 534 parents were...article 2008
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Dolhain, R.J.E.M. (author), ter Haar, N.T. (author), Hoefakker, S. (author), Tak, P.P. (author), de Ley, M. (author), Claassen, E. (author), Breedveld, F.C. (author), Miltenburg, A.M.M. (author), TNO Preventie en Gezondheid (author)Data concerning the presence of T-cell-derived cytokines in the rheumatic joint are conflicting, challenging the hypothesis that rheumatoid arthritis (RA) is a T-cell-mediated disease. In this study synovial tissue specimens of 11 patients with RA and eight patients with osteoarthritis (OA) were stained for interferon-gamma IFN-γ) and its...article 1996
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Brussaard, J.H. (author), van den Berg, H. (author), Hermus, R.J.J. (author), Walter, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To discuss the approach of the US Food and Nutrition Board (FNB) to daily nutrient requirements and its relevance for Europe. Setting: A workshop for experts from academia and regulatory bodies, together with members from the FNB Dietary Reference Intakes Subcommittee on Upper Reference Levels of Intake, and from the B-vitamins Expert...article 1999
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Feron, V.J. (author), Cassee, F.R. (author), Groten, J.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This paper reviews major activities outside the United States on human health issues related to chemical mixtures. In Europe an international study group on combination effects has been formed and has started by defining synergism and antagonism. Successful research programs in Europe include the development and application of statistically...article 1998
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Omboni, S. (author), Parati, G. (author), Castiglioni, P. (author), di Rienzo, M. (author), Imholz, B.P.M. (author), Langewouters, G.J. (author), Wesseling, K.H. (author), Mancia, G. (author), TNO Biomedical Instrumentation (author)Portapres is a noninvasive, beat-to-beat finger blood pressure (BP) monitor that has been shown to accurately estimate 24-hour intra-arterial BP at normal and high BPs. However, no information is available on the ability of this device to accurately track ambulatory BP variability. In 20 ambulatory normotensive and hypertensive subjects, we...article 1998
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Perenboom, R.J.M. (author), Davidse, W. (author), TNO Preventie en Gezondheid (author)Background. To increase the coverage of influenza vaccination in groups of patients at risk, an experiment was conducted in 1993, aimed at logistic support of general practitioners (GPs). Methods. Support was given to 56 GPs with 133 000 patients to select and invite patients at risk. The coverage of vaccination as a result of this experiment...article 1996
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van Spronsen, F.J. (author), Rijn, M. (author), Dorgelo, B. (author), Hoeksma, M. (author), Bosch, A.M. (author), Mulder, M.F. (author), de Klerk, J.B.C. (author), de Koning, T. (author), Rubio-Gozalbo, M.E. (author), de Vries, M. (author), Verkerk, P.H. (author)Background: The clinical severity of phenylalanine hydroxylase deficiency is usually defined by either pre-treatment phenylalanine (Phe) concentration or Phe tolerance at 5 years of age. So far, little is known about the course of Phe tolerance or the ability of both pre-treatment Phe and Phe tolerance at early age to predict Phe tolerance at...article 2009
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van Vliet, A.K. (author), van Thiel, G.C.F. (author), Naaktgeboren, N. (author), Cohen, L.H. (author), Gaubius Instituut TNO (author)Lovastatin and simvastatin are strong inhibitors of cholesterol synthesis in cultured human granulosa cells, as measured within 6 days after isolation, with IC50-values of respectively 27.0 and 18.2 nM obtained after 3.5 hours of incubation with the drugs. Pravastatin is a much weaker inhibitor of cholesterol synthesis (IC50-value of 977.8 nM)...article 1996
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de Jong, A.M. (author), Vink, P. (author), TNO Arbeid (author)This paper evaluates a step-by-step participatory approach to better work, applied in reducing the musculoskeletal workload in installation work. To arrive at a reduction in workload, a steering group led the project through the following steps: Introduction: defining the goal and informing all 7000 employees. Analysis: finding major loading...article 2002
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- Bank, R.A. (author), Jansen, E.J. (author), Beekman, B. (author), te Koppele, J.M. (author), Gaubius Instituut TNO (author) article 1996
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Pronk, A. (author), Preller, L. (author), Doekes, G. (author), Wouters, I.M. (author), Rooijackers, J. (author), Lammers, J.-W. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Associations have been observed between exposure to isocyanates, consisting mainly of oligomers, and respiratory symptoms and isocyanate specific sensitisation in spray painters. The aim of the present study was to assess associations between isocyanate exposure and more objective respiratory effect measures such as bronchial hyperresponsiveness...article 2009
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Kluft, C. (author), Meijer, P. (author), LaGuardia, K.D. (author), Fisher, A.C. (author), TNO Kwaliteit van Leven (author)Purpose: The aim of this study was to compare effects of the transdermal contraceptive patch, a desogestrel/ethinyl estradiol (EE)-containing, monophasic combination oral contraceptive (COC) and a levonorgestrel/EE-containing, triphasic COC on hemostasis variables. Study Design: This was a randomized, open-label study of 104 young women who...article 2008
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Lanting, C.I. (author), van Tijn, D.A. (author), Loeber, J.G. (author), Vulsma, T. (author), de Vijlder, J.J.M. (author), Verkerk, P.H. (author), TNO Preventie en Gezondheid (author)Context. Since the introduction of screening for congenital hypothyroidism (CH) in 1974, the optimal laboratory strategy has been the subject of debate. Objective. To assess the clinical effectiveness and cost-effectiveness of various types of thyroxine (T4)-based strategies to screen for CH. Design, Setting, and Participants. In the Netherlands...article 2005
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Verzijl, N. (author), Bank, R.A. (author), TeKoppele, J.M. (author), de Groot, J. (author), TNO Preventie en Gezondheid Gaubius instituut TNO (author)Purpose of review: Across the world, osteoarthritis is the most commonly occurring musculoskeletal disease of the elderly, affecting more than 25% of the population older than 60 years of age. By far the single greatest risk factor for the development of osteoarthritis is age, but a mechanism to explain this relation has not yet been identified....article 2003
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Bos, J.E. (author), Bles, W. (author), TNO Technische Menskunde (author)In an attempt to predict the amount of motion sickness given any kind of motion stimulus, we describe a model using explicit knowledge of the vestibular system. First, the generally accepted conflict theory is restated in terms of a conflict between a vertical as perceived by the sense organs like the vestibular system, and the subjective...article 1998
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Wenczl, E. (author), Pool, S. (author), Timmerman, A.J. (author), van der Schans, G.P. (author), Roza, L. (author), Schothorst, A.A. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)An immunochemical assay, i.e. sandwich enzyme-linked immunosorbent assay, has been modified to detect UV-induced damage in cellular DNA of monolayer-grown human melanocytes. The method is based on the binding of a monoclonal antibody to single-stranded DNA. The melanocytes derived from human foreskin of skin type II individuals were suspended...article 1997
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van Noort, J.M. (author), TNO Preventie en Gezondheid (author)The pathogenesis of multiple sclerosis (MS), the major neurological disease of young adults in the Western world, is still poorly understood, and no effective therapy to block MS is available as yet. The clinical symptoms of MS result from inflammatory damage to the insulating myelin sheath of axons in the CNS and - at later stages - to axons...article 1996
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Hueber-Becker, F. (author), Nohynek, G.J. (author), Meuling, W.J.A. (author), Benech-Kieffer, F. (author), Toutain, H. (author), TNO Voeding (author)We investigated the absorption of a commercial [14C]-PPD- containing oxidative dark-shade hair dye in human volunteers as well as in vitro using human or pig ear skin. The hair of eight male volunteers was cut to a standard length, dyed, washed, dried, clipped and collected. Hair, washing water, materials used in the study and a 24-h scalp wash...article 2004
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Lu, Z.F. (author), Doulabi, B.Z. (author), Huang, C.L. (author), Bank, R.A. (author), Helder, M.N. (author), TNO Kwaliteit van Leven (author)β1 integrins play a controversial role during chondrogenesis. Since the maturation of chondrocytes relies on a signaling switch from cell-cell to cell-matrix interactions, we hypothesized that β1 integrins play a different role at the earlier (mainly cell-cell interaction) from the later stage (mainly cell-matrix interaction) of chondrogenesis....article 2008