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Baleiras Couto, M.M. (author), Vogels, J.T.W.E. (author), Hofstra, H. (author), Huis in 'tVeld, J.H.J. (author), van der Vossen, J.M.B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The random amplified polymorphic DNA (RAPD) assay and the restriction enzyme analysis of PCR amplified rDNA are compared for the identification of the common spoilage yeasts Zygosaccharomyces bailii, Z. rouxii, Saccharomyces cerevisiae, Candida valida and C. lipolytica. Both techniques proved to be adequate tools for yeast identification. Since...
article 1995
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van Boheemen, P.A. (author), van den Hoogen, N.M. (author), Koolwijk, N. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
Six murine monoclonal antibodies (MAbs) specific for urokinase-type plasminogen activator (u-PA) were tested for their ability to inhibit u-PA activity in three different assays with respect to amidolytic activity, plasminogen activation and fibrinolytic activity. Two of the MAbs were able to inhibit the amidolytic activity of u-PA. One MAb (LMW...
article 1995
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Noorman, F. (author), Braat, E.A.M. (author), Rijken, D.C. (author), TNO Preventie en Gezondheid (author)
The balance of tissue-type plasminogen activator (t-PA) production and degradation determines its concentration in blood and tissues. Disturbance of this balance may result in either increased or decreased proteolysis. In the present study, we identified the receptor systems involved in the degradation of t-PA by human monocytes/macrophages in...
article 1995
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Kocken, C.H.M. (author), Milek, R.L.B. (author), Lensen, T.H.W. (author), Kaslow, D.C. (author), Schoenmakers, J.G.G. (author), Konings, R.N.H. (author)
article 1995
document
Instituut voor Toegepaste Radiobiologie en Immunologie TNO (author), Schmidt, J. (author), Krump-Konvalinkova, V. (author), Luz, A. (author), Goralczyk, R. (author), Snell, G. (author), Wendel, S. (author), Dorn, S. (author), Pedersen, L. (author), Strauss, P.G. (author), Erfle, V. (author)
hMt-c-fos-LTR transgenic mice (U. Ruther, D. Komitowski, F.R. Schubert, and E.F. Wagner. Oncogene 4, 861-865, 1989) developed bone sarcomas in 20% (3/15) of females at 448±25 days and in 8% (1/12) of males at 523 days. After infection of newborns with Akv, an infectious retrovirus derived from the ecotropic provirus of the AKR mouse, 69% (20/28)...
article 1995
document
van Helden, H.P.M. (author), van der Wiel, H.J. (author), Zijlstra, J.J. (author), Melchers, B.P.C. (author), Busker, R.W. (author)
The oximes HI-6, HLo-7, HGG-12, HGG-42 and obidoxime were used in a previously developed rat model to evaluate the therapeutic effects of oximes other than acetylcholinesterase (AChE) reactivation (so-called 'nonreactivating effects'). To test this anaesthetized, atropinized and artificially ventilated rats (n = 8 or 16) were poisoned with a...
article 1994
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Instituut CIVO-Toxicologie en Voeding TNO (author), den Besten, C. (author), van Bladeren, P.J. (author), Duizer, E. (author), Vervoort, J. (author), Rietjens, I.M.C.M. (author)
In the present study the oxidative dehalogenation of a para-halogenated phenol was studied using pentafluorophenol and its non-para-halogenated analogue 2,3,5,6-tetrafluorophenol as model compounds. 19F NMR was used to characterize the metabolite patterns. In order to study the primary oxidation products of the microsomal cytochrome P450...
article 1993
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Instituut voor verouderings- en vaatziekten onderzoek TNO (author), van de Kar, N.C.A.J. (author), Monnens, L.A.H. (author), Karmali, M.A. (author), van Hinsbergh, V.W.M. (author)
The epidemic form of the hemolytic uremic syndrome (HUS), beginning with an acute gastroenteritis, has been associated with a verocytotoxin-producing Escherichia coli infection. The endothelial cell is believed to play an important role in the pathogenesis of HUS. Endothelial cell damage by verocytotoxin-1 (VT-1) in vitro is potentiated by the...
article 1992
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van Nesselrooij, J.H.J. (author), Bruijntjes, J.P. (author), Garderen van-Hoetmer, A. (author), Tillapaugh-Fay, G.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Estrogen-induced pituitary lesions in rats were studied in time-sequence experiments using magnetic resonance imaging (MRI), hormone determinations and light microscopy. The main purpose of the study was to evaluate the usefulness of MRI in comparison with conventional biochemical and histopathological methods for detecting the pituitary lesions...
article 1991
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't Hart, B.A. (author), Botman, C.A.D. (author), Bakker, N.P.M. (author)
Peripheral blood mononuclear cells (PBMC) from Rhesus monkeys previously immunized with bovine type II collagen to induce arthritis were cultured with the same antigen. Because the native protein is poorly soluble in culture medium a heating step is often used. The antigen in this form induced PBMC proliferation, but epitopes for the induction...
article 1991
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