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Kastelein, R.A. (author), van der Heul, S. (author), van der Veen, J. (author), Verboom, W.C. (author), Jennings, N. (author), de Haan, D. (author), Reijnders, P.J.H. (author), TNO Defensie en Veiligheid (author)World-wide many cetaceans drown incidentally in fishing nets. To reduce the unwanted bycatch in gillnets, pingers (acoustic alarms) have been developed that are attached to the nets. In the European Union, pingers will be made compulsory in some areas in 2005 and in others in 2007. However, pingers may effect non-target marine fauna such as fish...article 2007
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Kastelein, R. (author), Gransier, R. (author), van Mierlo, R. (author), Hoek, L. (author), de Jong, C.A.F. (author)To set safety criteria for levels of sounds produced during pile driving for offshore wind parks, temporary hearing threshold shifts sTTSsd were studied in a harbor porpoise and two harbor seals. A psychoacoustic behavioral technique was used to quantify TTS and hearing recovery in the animals exposed to underwater sounds swhite noise in a 1/1...article 2011
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TNO Preventie en Gezondheid (author), Sijbrands, E.J.G. (author), Westendorp, R.G.J. (author), Paola Lombardi, M. (author), Havekes, L.M. (author), Frants, R.R. (author), Kastelein, J.J.P. (author), Smelt, A.H.M. (author)Life expectancy of patients with familial hypercholesterolaemia is decreased. Some untreated patients reach a normal life span and, therefore, additional risk factors and the type of mutation in the low-density lipoprotein (LDL) receptor gene are likely to influence the clinical outcome. We determined all cause mortality in kindreds with the...article 2000
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Kastelein, R.A. (author), Rippe, H.T. (author), Vaughan, N. (author), Schooneman, N.M. (author), Verboom, W.C. (author), de Haan, D. (author), TNO Fysisch en Elektronisch Laboratorium (author)In an attempt to test the effectiveness of sounds in deterring harbor porpoises from nets and reducing porpoise bycatch in gill net fisheries, two harbor porpoises, kept in a large floating pen at Neeltje Jans, The Netherlands, were subjected to 3 different underwater sounds. The effect of each sound was judged by comparing the animals' behavior...article 2000
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- Stokman, G. (author), van den Hoek, A.M. (author), Denker Thorbekk, D. (author), Pieterman, E.J. (author), Skovgård Veidal, S. (author), Basta, B. (author), Iruarrizaga-Lejarreta, M. (author), van der Hoorn, J.W. (author), Verschuren, L. (author), Berbée, J.F.P. (author), Rensen, P.C.N. (author), Skjæret, T. (author), Alonso, C. (author), Feigh, M. (author), Kastelein, J.J.P. (author), Friedman, S.L. (author), Princen, H.M.G. (author), Fraser, D.A. (author) article 2020
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- Kastelein, M. (author), Davidse, W. (author), Bergsma, E.E. (author), van de Water, H.P.A. (author) article 1992
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- Kastelein, R.A. (author), von Benda-Beckmann, A.M. (author), Lam, F.-P.A. (author), Jansen, E. (author), de Jong, C.A.F. (author) article 2019
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- Kastelein, R.A. (author), Hoek, L. (author), de Jong, C.A.F. (author) article 2011
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Kastelein, R.A. (author), Jennings, N. (author), Verboom, W.C. (author), de Haan, D. (author), Schooneman, N.M. (author), TNO Defensie en Veiligheid (author)Small cetacean bycatch in gillnet fisheries may be reduced by deterring odontocetes from nets acoustically. However, different odontocete species may respond differently to acoustic signals from alarms. Therefore, in this study a striped dolphin and a harbour porpoise were subjected simultaneously to sounds produced by the XP-10 experimental...article 2006
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- Cnossen, H. (author), Kastelein, J. (author), Barendsz, T. (author), TNO Voeding (author) article 2003
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Kastelein, R.A. (author), Helder-Hoek, L. (author), van de Voorde, S. (author), von Von Benda-Beckmann, A.M. (author), Lam, F.P.A. (author), Jansen, E. (author), de Jong, C.A.F. (author), Ainslie, M.A. (author)In seismic surveys, reflected sounds from airguns are used under water to detect gas and oil below the sea floor. The airguns produce broadband high-amplitude impulsive sounds, which may cause temporary or permanent threshold shifts (TTS or PTS) in cetaceans. The magnitude of the threshold shifts and the hearing frequencies at which they occur...article 2017
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Kastelein, R.A. (author), Verboom, W.C. (author), Jennings, N. (author), de Haan, D. (author), TNO Defensie en Veiligheid (author)The use of ultrasonic sounds in alarms for gillnets may be advantageous, but the deterring effects of ultrasound on porpoises are not well understood. Therefore a harbor porpoise in a large floating pen was subjected to a continuous 50 kHz pure tone with a source level of 122 +/- 3dB (re 1uPa, rms). When the test signal was switched on during...article 2008
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Gaubius Instituut TNO (author), Lombardi, P. (author), Sijbrands, E.J.G. (author), van de Giessen, K. (author), Smelt, A.H.M. (author), Kastelein, J.J.P. (author), Frants, R.R. (author), Havekes, L.M. (author)Familial hypercholesterolemia (FH) results from mutations in the low density lipoprotein receptor (LDLR) gene. We applied denaturing gradient gel electrophoresis (DGGE) to screen for sequence variations in the coding and splice site consensus sequences of the LDLR gene. For amplification of each exon by the polymerase chain reaction (PCR),...article 1995
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- TNO Bouw (author), Ham, P.J. (author), Kastelein, J. (author) article 1999
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- Kastelein, R.A. (author), Steen, N. (author), Gransier, R. (author), de Jong, C.A.F. (author) article 2013
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- Kastelein, R.A. (author), de Jong, C.A.F. (author), Tougaard, J. (author), Helder-Hoek, L. (author), Defillet, L.N. (author) article 2022
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von Benda-Beckmann, A.M. (author), Ketten, D.R. (author), Lam, F.P.A. (author), de Jong, C.A.F. (author), Muller, R.A.J. (author), Kastelein, R.A. (author)Application of a kurtosis correction to frequency-weighted sound exposure level (SEL) improved predictions of risk of hearing damage in humans and terrestrial mammals for sound exposures with different degrees of impulsiveness. To assess whether kurtosis corrections may lead to improved predictions for marine mammals, corrections were applied to...article 2022
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TNO Kwaliteit van Leven (author), Monraats, P.S. (author), Rana, J.S. (author), Nierman, M.C. (author), Pires, N.M.M. (author), Zwinderman, A.H. (author), Kastelein, J.J.P. (author), Kuivenhoven, J.A. (author), de Maat, M.P.M. (author), Rittersma, S.Z.H. (author), Schepers, A. (author), Doevendans, P.A.F. (author), de Winter, R.J. (author), Tio, R.A. (author), Frants, R.R. (author), Quax, P.H.A. (author), van der Laarse, A. (author), van der Wall, E.E. (author), Jukema, J.W. (author)OBJECTIVES: We sought to identify polymorphisms in genes that predispose to restenosis. BACKGROUND: Variations in the lipoprotein lipase (LPL) gene have been implicated in a number of pathophysiologic conditions associated with coronary heart disease. The present study examines the impact of polymorphisms in the LPL gene on restenosis (defined...article 2005
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Gaubius instituut TNO (author), de Maat, M.P.M. (author), Jukema, J.W. (author), Ye, S. (author), Zwinderman, A.H. (author), Moghaddam, P.H. (author), Beekman, M. (author), Kastelein, J.J.P. (author), van Boven, A.J. (author), Bruschke, A.V.G. (author), Humphries, S.E. (author), Kluft, C. (author), Henney, A.M. (author)It has proved difficult to identify high-risk patients for atherosclerosis and to determine how they might respond to medication. Recently, a common promoter variant of the human stromelysin-1 gene has been reported, which has been shown to affect the transcription. We investigated whether this polymorphism had any impact on the risk of events,...article 1999
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von Benda-Beckmann, A.M. (author), Ketten, D.R. (author), Lam, F.P.A. (author), de Jong, C.A.F. (author), Müller, R.A.J. (author), Kastelein, R.A. (author)An error was found in Table I of the original paper (von Benda-Beckman et al., 2022), where the two kurtosis values for intermittent and continuous sonar signals at 6.5 kHz were inadvertently interchanged. The correct values were used in the analysis and, thus, the error in Table I did not affect our results. A corrected version of Table I is...article 2022