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Terhal, P.A. (author), van Dommelen, P. (author), Le Merrer, M. (author), Zankl, A. (author), Simon, M.E. (author), Smithson, S.F. (author), Marcelis, C. (author), Kerr, B. (author), Kinning, E. (author), Mansour, S. (author), Hennekam, R.C. (author), van der Hout, A.H. (author), Cormier-Daire, V. (author), Lund, A.M. (author), Goodwin, L. (author), Mégarbané, A. (author), Lees, M. (author), Betz, R.C. (author), Tobias, E.S. (author), Coucke, P. (author), Mortier, G.R. (author)
From data collected via a large international collaborative study, we have constructed a growth chart for patients with molecularly confirmed congenital spondylo-epiphyseal dysplasia (SEDC) and other COL2A1 related dysplasias. The growth chart is based on longitudinal height measurements of 79 patients with glycine substitutions in the triple...
article 2012
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Banta, H.D. (author), Schersten, T. (author), Jonsson, E. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
The field of minimally invasive therapy (MIT) raises many important issues for the future of health care. It seems inevitable that MIT will replace much conventional surgery. This trend is good for society and good for patients. The health care system, however, may find the change disruptive. The need for hospital beds will shrink. Day surgery...
article 1993
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van Ree, J.H. (author), Gijbels, M.J.J. (author), van den Broek, W.J.A.A. (author), Hofker, M.H. (author), Havekes, L.M. (author), TNO Preventie en Gezondheid (author)
Apolipoprotein (apo) E-deficient mice were fed a hypercholesterolemic diet for 14 weeks. Mean serum cholesterol levels rose to 37.5 mM. Upon complete necroscopy, massive xanthomatous lesions were noticed in various tissues, with a predilection for subcutaneous and peritendinous tissues, while control animals on the same diet (3.4 mM serum...
article 1995
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te Velthuis- Wierik, E.J.M. (author), van den Berg, H. (author), Weststrate, J.A. (author), van het Hof, K.H. (author), de Graaf, C. (author), TNO Voeding (author)
Objective: Dietary fat intake is higher than recommended in most western countries and is associated with the prevalence of cardiovascular diseases, obesity and cancer. The growing public concern about the adverse effects of a high fat intake has led to an increased availability of 'reduced-fat' products. Consumption of reduced-fat products...
article 1996
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Walraven, P.L. (author), Instituut voor Zintuigfysiologie TNO (author)
THE Stiles–Crawford effect1,2, or the dependence of luminous efficiency on the eccentricity of the point of entry of the light in the pupil, is a function of the wavelength of the light. In Fig. 1 is given the inverse 1/ of the luminous efficiency as a function of wave-length at a distance of 3.5 mm from the point of maximum efficiency,...
article 1966
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McKee, R.H. (author), Lammers, J.H.C.M. (author), Hoogendijk, E.M.G. (author), Emmen, H.H. (author), Muijser, H. (author), Barsotti, D.A. (author), Owen, D.E. (author), Kulig, B.M. (author), TNO Kwaliteit van Leven (author)
As a preliminary step to evaluating the acute neurobehavioral effects of hydrocarbon solvents and to establish a working model for extrapolating animal test data to humans, joint neurobehavioral/toxicokinetic studies were conducted which involved administering ethanol to rats and volunteers. The specific objectives of the present studies were to...
article 2006
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de Hollander, E.L. (author), Zwart, L. (author), de Vries, S.I. (author), Wendel-Vos, W. (author)
Objective: To examine whether the "Short QUestionnaire to ASsess Health-enhancing physical activity" (SQUASH) and the "Injuries and Physical Activity in the Netherlands" questionnaire ("Ongevallen en Bewegen in Nederland," OBiN) were valid in assessing adherence to physical activity (PA) guidelines. Study Design and Setting: Participants (N =...
article 2012
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Thurlings, M.E. (author), Brouwer, A.M. (author), van Erp, J.B.F. (author), Blankertz, B. (author), Werkhoven, P.J. (author)
Event-related potential (ERP)-based brain–computer interfaces (BCIs) employ differences in brain responses to attended and ignored stimuli. Typically, visual stimuli are used. Tactile stimuli have recently been suggested as a gaze-independent alternative. Bimodal stimuli could evoke additional brain activity due to multisensory integration which...
article 2012
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Dominy, N.J. (author), Davoust, E. (author), Minekus, M. (author), TNO Voeding (author)
Despite occurring in a wide variety of taxa, deliberate soil consumption (geophagy) is a poorly understood behavior. In humans, geophagy is sometimes considered aberrant or a sign of metabolic dysfunction. However, geophagy is normally assigned an adaptive function in nonhuman primates and various other organisms. One hypothesis submits that...
article 2004
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Teune, M.J. (author), van Wassenaer, A.G. (author), van Dommelen, P. (author), Mol, B.W.J. (author), Opmeer, B.C. (author)
Objective: Many obstetric interventions are performed to improve long-term neonatal outcome. However, long-term neonatal outcome is usually not a primary outcome because it is time-consuming and expensive. The aim of this project was to identify different perinatal risk indicators and to develop prediction models for neurologic morbidity at 2...
article 2011
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Bunt, A.A. (author), Sanders, A.F. (author)
An experiment is reported on the effects of cognitive similarity on proactive and retroactive interference (PI, RI) in short term memory. To avoid confounding between cognitive and acoustic similarity, the materials - i.e. words and digits - were matched with respect to vowel pattern. Effects of both PI and RI were found on recall of words,...
article 1972
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Noorman, F. (author), Braat, E.A.M. (author), Rijken, D.C. (author), TNO Preventie en Gezondheid (author)
The balance of tissue-type plasminogen activator (t-PA) production and degradation determines its concentration in blood and tissues. Disturbance of this balance may result in either increased or decreased proteolysis. In the present study, we identified the receptor systems involved in the degradation of t-PA by human monocytes/macrophages in...
article 1995
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Instituut voor verouderings- en vaatziekten onderzoek TNO (author), van de Kar, N.C.A.J. (author), Monnens, L.A.H. (author), Karmali, M.A. (author), van Hinsbergh, V.W.M. (author)
The epidemic form of the hemolytic uremic syndrome (HUS), beginning with an acute gastroenteritis, has been associated with a verocytotoxin-producing Escherichia coli infection. The endothelial cell is believed to play an important role in the pathogenesis of HUS. Endothelial cell damage by verocytotoxin-1 (VT-1) in vitro is potentiated by the...
article 1992
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Zoetelief, J. (author), Eisenhauer, C.M. (author), Coyne, J.J. (author)
Displacement corrections for in-phantom measurements with ionisation cham- bers for the purpose of mammography are large and represent a major correction to consider for dose determinations. Experimental data on displacement corrections depend to a large degree on the model used to extrapolate to zero cavity radius. Calculations of displacement...
article 1990
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TNO Preventie en Gezondheid (author), Rietveld, M.J.H. (author), van der Valk, J.C. (author), Bongers, I.L. (author), Stroet, T.M. (author), Slagboom, P.E. (author), Boomsma, D.I. (author)
This study reports on zygosity determination in twins of childhood age. Parents responded to questionnaire items dealing with twin similarity in physical characteristics anti frequency of mistaking one twin for another by parents, relatives and strangers. The accuracy of zygosity diagnosis was evaluated across twins aged 6, 8, and 10 and across...
article 2000
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TNO Kwaliteit van Leven (author), Uitterlinden, E.J. (author), Jahr, H. (author), Koevoet, J.L.M. (author), Jenniskens, Y.M. (author), Bierma-Zeinstra, S.M.A. (author), de Groot, J. (author), Verhaar, J.A.N. (author), Weinans, H. (author), van Osch, G.J.V.M. (author)
Objective: To investigate the effect of glucosamine (GlcN) in a human osteoarthritic explant model on expression of genes involved in anabolic and catabolic activities of chondrocytes. Methods: Human osteoarthritic explants, obtained during knee arthroplasty surgery, were pre-cultured (3 days) and treated with glucosamine-hydrochloride (GlcN-HCl...
article 2006
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