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Desprez, B. (author), Birk, B. (author), Blaauboer, B. (author), Boobis, A. (author), Carmichael, P. (author), Cronin, M.T.D. (author), Curie, R. (author), Daston, G. (author), Hubesch, B. (author), Jennings, P. (author), Klaric, M. (author), Kroese, D. (author), Mahony, C. (author), Ouédraogo, G. (author), Piersma, A. (author), Richarz, A.N. (author), Schwarz, M. (author), van Benthem, J. (author), van de Water, B. (author), Vinken, M. (author)
Repeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to chemicals. Non-animal approaches have gained importance in the last decades because of ethical considerations as well as due to scientific reasons calling for more human-based strategies. A critical aspect of this...
article 2019
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Vink, R.M. (author), van Dommelen, P. (author), van der Pal, S.M. (author), Eikhout, I. (author), Pannebakker, F.D. (author), Klein Velderman, M. (author), Haagmans, M. (author), Mulder, T. (author), Dekker, M. (author)
Background Adverse Childhood Experiences (ACEs) may have a life-long impact on mental health and are related to physical disease, such as diabetes and cardiovascular diseases in adulthood. Research on ACEs suffers from recall bias when performed with adults. Objective To estimate the prevalence of ACEs and the interrelationships between ACEs as...
article 2019
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Swuste, P. (author), Zwaard, W. (author), Groeneweg, J. (author), Guldenmund, F. (author)
The origin of occupational safety, as an area of main interest of the government, the industry, the unions, and scientists starts in the Netherlands at the end of the 19th century. Roughly in the same period occupational medicine becomes a separate domain. Only just after World War II are safety professionals organised in associations. Starting...
article 2019
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Goede, H.A. (author), McNally, K. (author), Gorce, J.P. (author), Marquart, H. (author), Warren, N.D. (author), Fransman, W. (author), Tischer, M. (author), Schinkel, J. (author)
This article describes the development of a mechanistic model for underpinning the dermal Advanced REACH Tool (dART), an extension of the existing ART model and its software platform. It was developed for hand exposure to low volatile liquids (vapour pressure ≤ 10 Pa at 20°C) including solids-in-liquid products. The model is based on an existing...
article 2019
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Kuiper, O.X. (author), Bos, J.E. (author), Diels, C. (author), Cammaerts, K. (author)
We investigated whether motion sickness analogous to carsickness can be studied in a moving base simulator, despite the limited motion envelope. Importantly, to avoid simulator sickness, vision outside the simulator cabin was restricted. Participants (N = 16) were exposed blindfolded to 15-min lateral sinusoidal motion at 0.2 Hz and 0.35 Hz on...
article 2019
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Zeitlin, J. (author), Alexander, S. (author), Barros, H. (author), Blondel, B. (author), Delnord, M. (author), Durox, M. (author), Gissler, M. (author), Hindori-Mohangoo, A.D. (author), Hocquette, A. (author), Szamotulska, K. (author), Macfarlane, A. (author)
In November 2018, the Euro-Peristat collaboration published a new European Perinatal Health Report based on national-level indicators of mothers’ and babies’ health in 2015 in current EU member states and Iceland, Norway, and Switzerland, a total of 31 countries with over five million births.1 Euro-Peristat’s indicator set includes ten core and...
article 2019
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Bouwhuis, S. (author), Geuskens, G.A. (author), van der Beek, A.J. (author), Boot, C.R.L. (author)
We are writing in regards to the review by Koranyi et al (1) on precarious employment and occupational accidents and injuries. In the review, multiple-job holding was classified as a type of precarious employment. In this letter, we argue multiple-job holding should not be considered a type of precarious employment and that multiple-job holders...
article 2019
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Pannebakker, N.M. (author), Fleuren, M.A.H. (author), Vlasblom, E. (author), Numans, M.E. (author), Reijneveld, S.A. (author), Kocken, P.L. (author)
Background: The aim of this study is to understand the determinants of adherence to wrap-around care (WAC) by professional care providers working in child and family services. WAC is a care coordination method targeting families with complex needs. The core components of WAC involve activating family members and the social network, integrating...
article 2019
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Huijs, J.J.J.M. (author), Houtman, I.L.D. (author), Taris, T.W. (author), Blonk, R.W.B. (author)
Background The present study aimed to investigate the effects of a stepwise, bottom-up participatory program with a tailor-made intervention process addressing the level of mental retirement in a sample of Dutch employees. Mental retirement refers to feelings of being disconnected from your work and your organization. Prevention of mental...
article 2019
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Tielman, M.L. (author), Neerincx, M.A. (author), Pagliari, C. (author), Rizzo, A. (author), Brinkman, W.P. (author)
Background: Digital health interventions can fill gaps in mental healthcare provision. However, autonomous e-mental health (AEMH) systems also present challenges for effective risk management. To balance autonomy and safety, AEMH systems need to detect risk situations and act on these appropriately. One option is sending automatic alerts to...
article 2019
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van der Veer, C. (author), Hertzberger, R.Y. (author), Bruisten, S.M. (author), Tytgat, H.L.P. (author), Swanenburg, J. (author), de Kat Angelino-Bart, A. (author), Schuren, F. (author), Molenaar, D. (author), Reid, G. (author), de Vries, H. (author), Kort, R. (author)
Background: A vaginal microbiota dominated by lactobacilli (particularly Lactobacillus crispatus) is associated with vaginal health, whereas a vaginal microbiota not dominated by lactobacilli is considered dysbiotic. Here we investigated whether L. crispatus strains isolated from the vaginal tract of women with Lactobacillus-dominated vaginal...
article 2019
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Gerrett, N. (author), Kingma, B.R.M. (author), Sluijter, R. (author), Daanen, H.A.M. (author)
The Tokyo Olympics and Paralympic games in 2020 will be held in hot and humid conditions. Heat acclimation (in a climatic chamber) or heat acclimatization (natural environment) is essential to prepare the (endurance) athletes and reduce the performance loss associated with work in the heat. Based on the 1990-2018 hourly meteorological data of...
article 2019
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van der Veen, D.J. (author), Döpp, C.M. (author), Siemonsma, P.C. (author), Nijhuis-van der Sanden, M.W.G. (author), de Swart, B.J.M. (author), Steultjens, E.M. (author)
Background: Stroke has a major impact on survivors and their social environment. Care delivery is advocated to become more client-centered and home-based because of their positive impact on client outcomes. The objective of this study was to explore professionals' perspectives on the provision of Home-Based Stroke Rehabilitation (HBSR) in the...
article 2019
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Vesela, S. (author), Kingma, B.R.M. (author), Frijns, A.J.H. (author), van Marken Lichtenbelt, W.D. (author)
The quality of local skin temperature prediction by thermophysiological models depends on the local skin blood flow (SBF) control functions. These equations were derived for low activity levels (0.8-1 met ) and mostly in sitting or supine position. This study validates and discusses the prediction of foot SBF during activities of 1-3 met in male...
article 2019
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Bouwhuis, S. (author), Geuskens, G.A. (author), Boot, C.R.L. (author), van der Beek, A.J. (author), Bongers, P.M. (author)
Introduction Precarious employment is associated with poor health. Among employees in precarious employment, those with multiple jobs may face additional health risks, e.g. due to combining work schedules and job roles. Our research question is: do differences in health exist between multiple and single job holders in precarious employment?...
article 2019
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de Lijster, G.P.A. (author), Kok, G. (author), Kocken, P.L. (author)
Background. The development of school-based programs for preventing adolescent sexual harassment often lacks an evidence-based approach and use of proper theories. Appropriate stakeholders are often not involved in the development process. To help improve this process, we used the Intervention Mapping framework to retrospectively evaluate the...
article 2019
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van Til, J.A. (author), Groothuis-Oudshoorn, C.G.M. (author), Vlasblom, E. (author), Kocken, P.L. (author), Boere-Boonekamp, M.M. (author)
Objective. As part of the Models of Child Health Appraised (MOCHA) project, this study aimed to answer the following research questions: 1) How do European citizens perceive the quality of primary health care provided for children? And 2) What are their priorities with respect to quality assessment of primary health care aimed at satisfying...
article 2019
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Huijs, J.J.J.M. (author), Houtman, I.L.D. (author), Blonk, R.W.B. (author)
Background. The aim of this study is to develop a new measure for the concept of mental retirement and test the construct validity of the measure. Employees who are ‘mentally retired’ are present at their work physically, but have already said their goodbyes mentally. Mental retirement has a three-factor structure: developmental proactivity,...
article 2019
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Verhoeckx, K. (author), Bogh, K.L. (author), Dupont, D. (author), Egger, L. (author), Gadermaier, G. (author), Larre, C. (author), Mackie, A. (author), Menard, O. (author), Adel-Patient, K. (author), Picariello, G. (author), Portmann, R. (author), Smit, J. (author), Turner, P. (author), Untersmayr, E. (author), Epstein, M.M. (author)
The current allergenicity assessment of novel proteins is based on the EFSA GMO guidance. Recently, EFSA launched a new guidance document on allergenicity assessment of GM plants (2017). This document describes, amongst other topics, the new scientific and regulatory developments on in vitro protein digestibility tests. The EFSA GMO Panel stated...
article 2019
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Spini, G. (author), van Heesch, M.P.P. (author), Veugen, P.J.M. (author), Chatterjea, S. (author)
Optimizing the workflow of a complex organization such as a hospital is a difficult task. An accurate option is to use a real-time locating system to track locations of both patients and staff. However, privacy regulations forbid hospital management to assess location data of their staff members. In this exploratory work, we propose a secure...
article 2019
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