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Foti, M.J. (author), Médici, R. (author), Ruijssenaars, H.J. (author)Pseudomonas putida S12 was engineered for the production of monoethanolamine (MEA) from glucose via the decarboxylation of the central metabolite l-serine, which is catalyzed by the enzyme l-serine decarboxylase (SDC).The host was first evaluated for its tolerance towards MEA as well as its endogenous ability to degrade this alkanolamine. Growth...article 2013
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van der Greef, J. (author), van Wietmarschen, H. (author), van Ommen, B. (author), Verheij, E.R. (author)Metabolites have played an essential role in our understanding of life, health, and disease for thousands of years. This domain became much more important after the concept of metabolism was discovered. In the 1950s, mass spectrometry was coupled to chromatography and made the technique more application-oriented and allowed the development of...article 2013
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Visser, H. (author), Joosten, V. (author), Punt, P.J. (author), Gusakov, A.V. (author), Olson, P.T. (author), Joosten, R. (author), Bartels, J. (author), Visser, J. (author), Sinitsyn, A.P. (author), Emalfarb, M.A. (author), Verdoes, J.C. (author), Wery, J. (author)The filamentous fungus C1 was developed into an expression platform for screening and production of diverse industrial enzymes. C1 shows a lowviscosity morphology in submerged culture, enabling the use of complex growth and production media. This morphology furthermore allowed C1 to be used as a host for high-throughput robotic screening of gene...article 2011
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Könemann, R. (author), Bosch, T. (author), de Looze, M.P. (author)The design of a work station generally prescribes a global movement pattern of the operator, but also leaving some degrees of freedom regarding movement strategy. For a specific order picking work station, we studied the movement strategies, the underlying factors and its impact on performance. Eight subjects performed a task comprising, the...article 2012
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- Bekker, C. (author), Kuijpers, E. (author), Brouwer, D.H. (author), Vermeulen, R. (author), Fransman, W. (author) article 2015
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Robertson, M. (author), Vink, P. (author)There are many definitions of new ways of work, but working with a computer at another location than at the office or at the clients' location with Information Communication Technology as a support is becoming more prevalent. A new office having shared desks and facilitating informal meetings along with a changed leadership style is yet another...article 2012
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- Reijneveld, S.A. (author), de Meer, G. (author), Wiefferink, C.H. (author), Crone, M.R. (author), TNO Kwaliteit van Leven (author) article 2008
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Hafkamp-De Groen, E. (author), Mohangoo, A.D. (author), Landgraf, J.M. (author), de Jongste, J.C. (author), Duijts, L. (author), Moll, H.A. (author), Jaddoe, V.W.V. (author), Hofmane, A. (author), Raat, H. (author)We assessed whether dynamic preschool wheezing patterns affect health-related quality of life (HRQOL) at age 4 years. The study included 3878 children participating a prospective cohort study. Information on preschool wheezing was obtained by questionnaire and children were categorised into: never, early, late and persistent wheezing. At age 4...article 2013
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- Vlasveld, M.C. (author), van der Feltz-Cornelis, C.M. (author), Bültmann, U. (author), Beekman, A.T.F. (author), van Mechelen, W. (author), Hoedeman, R. (author), Anema, J.R. (author) article 2012
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Blaauboer, M.E. (author), Emson, C.L. (author), Verschuren, L. (author), van Erk, M. (author), Turner, S.M. (author), Everts, V. (author), Hanemaaijer, R. (author), Stoop, R. (author)Collagen deposition is a key process during idiopathic pulmonary fibrosis; however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily available and it is difficult to identify changes in collagen content, since standard collagen analyses do not...article 2013
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Meijer, C. (author), Timmer, A. (author), de Vries, E.G.E. (author), Groten, J.P. (author), Knol, A. (author), Zwart, N. (author), Dam, W.A. (author), Sleijfer, D.Th. (author), Mulder, N.H. (author)Cisplatin (CDDP) is an extremely active drug in the treatment of germ- cell tumours. Earlier, we found an unexpected inverse correlation between the total amount of sulfhydryl groups and CDDP sensitivity in a panel of 3 human germ-cell tumour and 3 colon-carcinoma cell lines. Major components of the sulfhydryl groups are glutathione and...article 2000
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Willems, N. (author), Yang, H.Y. (author), Langelaan, M.L.P. (author), Tellegen, A.R. (author), Grinwis, G.C.M. (author), Kranenburg, H.J.C. (author), Riemers, F.M. (author), Plomp, S.G.M. (author), Craenmehr, E.G.M. (author), Dhert, W.J.A. (author), Papen-Botterhuis, N.E. (author), Meij, B.P. (author), Creemers, L.B. (author), Tryfonidou, M.A. (author)Introduction: Chronic low back pain due to intervertebral disc (IVD) degeneration is associated with increased levels of inflammatory mediators. Current medical treatment consists of oral anti-inflammatory drugs to alleviate pain. In this study, the efficacy and safety of a novel thermoreversible poly-N-isopropylacrylamide MgFe-layered double...article 2015
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Atuonwu, J.C. (author), van Straten, G. (author), van Deventer, H.C. (author), van Boxtel, A.J.B. (author)This work presents a mixed integer nonlinear programming (MINLP) formulation for the design of energy-efficient multistage adsorption dryers within constraints on product temperature and moisture content. Apart from optimizing temperatures and flows, the aim is to select the most efficient adsorbent per stage and product to air flow...article 2012
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Ahmadi-Abhari, S. (author), Woortman, A.J.J. (author), Hamer, R.J. (author), Oudhuis, A.A.C.M. (author), Loos, K. (author)Starch is an omnipresent constituent which is used for its nutritional and structuring properties. Recently concerns have been raised since starch is a source of readily available glucose which is tightly correlated with diabetes type II and obesity. For this reason, the possibilities for modulating the digestibility of starch while preserving...article 2013
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- Iyer, V. (author) article 2013
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Bergmann Tiest, W.M. (author), Kosters, N.D. (author), Kappers, A.M.L. (author), Daanen, H.A.M. (author)Phase change materials (PCMs) are increasingly incorporated in textiles in order to serve as a thermal buffer when humans change from a hot to a cold environment and the reverse. Due to the absence of wetness sensors in the skin, cooling of the skin may be perceived as a sensation of wetness instead of cold. In order to investigate if this...article 2012
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Pannebakker, N.M. (author), Kocken, P.L. (author), Theunissen, M.H.C. (author), van Mourik, K. (author), Crone, M.R. (author), Numans, M.E. (author), Reijneveld, S.A. (author)Background Multiproblem families are multi-users of psychosocial and health care services, but little is known about factors associated with their care utilization in the general population. The aim of this study was to assess which factors were associated with the overall and psychosocial care use of two members—i.e., child and parent—of each...article 2018
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Drupsteen, L. (author), Hasle, P. (author)If organizations would be able to learn more effectively from incidents that occurred in the past, future incidents and consequential injury or damage can be prevented. To improve learning from incidents, this study aimed to identify limiting factors, i.e. the causes of the failure to effectively learn. In seven organizations focus groups were...article 2014
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van Lettow, B. (author), de Vries, H. (author), Burdorf, A. (author), Norman, P. (author), van Empelen, P. (author)Objective: Previous research has focused mostly on abstainer and/or general drinker prototypes. The present studies examined an abstainer, moderate drinker and heavy drinker prototype in relation to drinking behaviour. Design: Two studies among young adults aged 18–25 (paper-and-pencil, cross-sectional, N = 140; online, prospective, N = 451)...article 2013
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Steenstra, I.A. (author), Lee, H. (author), de Vroome, E.M.M. (author), Busse, J.W. (author), Hogg-Johnson, S.J. (author)Introduction Return-to-work (RTW) status is an often used outcome in work and health research. In low back pain, work is regarded as a normal activity a worker should return to in order to fully recover. Comparing outcomes across studies and even jurisdictions using different definitions of RTW can be challenging for readers in general and when...article 2012