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Gopaul, V.S. (author), Pieterman, E.J. (author), Princen, H.M.G. (author), Bergenholm, L. (author), Lundborg, E. (author), Cavallin, A. (author), Johansson, M.J. (author), Hawthorne, G. (author), Björkbom, A. (author), Hammarberg, M. (author), Li, X. (author), Jarke, A. (author), Bright, J. (author), Svensson, L. (author), Jansson-Löfmark, R. (author), Abrahamsson, B. (author), Agrawal, R. (author), Hurt-Camejo, E. (author)We investigated the effects of mineral oil on statin pharmacokinetics and inflammatory markers in animal models. A new synthesis strategy produced regioisomers that facilitated the characterization of the main metabolite (M1) of atorvastatin, a lipophilic statin, in C57BL/6NCrl mice. The chemical structure of M1 in mice was confirmed as ortho...article 2021
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van der Ploeg, C.P.B. (author), Grevinga, M. (author), Eekhout, I. (author), Vlasblom, E. (author), Lanting, C.I. (author), van Minderhout, H.M. (author), Dijk-van der Poel, J. (author), van den Akker-van Marle, M.E. (author), Verkerk, P.H. (author)Comment on the article: Costs and effects of conventional vision screening and photoscreening in the Dutch preventive child health care system. We thank professor Simonsz for his comments, since it gives us the opportunity to clarify some of our findings. Indeed, with the price for the photoscreening device of €2.29 per child as calculated in...article 2021
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Klein Velderman, M. (author)Op de Dag van de Scheiding - 10 september 2021 - ontving ScheidingsATLAS de ZonMw Parel. Een ereprijs voor een bijzonder goed project, met grote maatschappelijke impact. De korte en laagdrempelige training steunt scheidende partners in hun rol als ouders.article 2021
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van Dommelen, P. (author), van Zoonen, R. (author), Vlasblom, E. (author), Wit, J.M. (author), Beltman, M. (author)Inleiding: Het doel van dit onderzoek was het ontwikkelen van een richtlijn voor Jeugdgezondheidszorg (JGZ)-professionals om aandoeningen die samenhangen met een kleine lengte (en/of trage groei) of een grote lengte (en/of snelle groei) vroegtijdig op te sporen. Methode: Op basis van literatuur en advies van een expertcommissie werd de vorige...article 2021
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van der Kooij, D.C. (author), de Ronde, R.W. (author), de Wilde, J.A. (author), Klein Veldermam, M. (author), Crone, M.R. (author)Inleiding: Eind 2019 werd de wereld opgeschrikt door COVID-19 (Corona Virus Disease-2019). Hoewel er veel onderzoek is gedaan, is weinig bekend over de invloed van COVID-19 op het leven en welzijn van adolescenten van 12 tot 18 jaar in Nederland. Methode: Dit mixed-methods, participatief onderzoek is uitgevoerd met behulp van zes adolescenten....article 2021
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Sentenac, M. (author), Benhammou, V. (author), Aden, U. (author), Ancel, P.Y. (author), Bakker, L.A. (author), Bakoy, H. (author), Barros, H. (author), Baumann, N. (author), Funck Bilsteen, J. (author), Boerch, K. (author), Croci, I. (author), Cuttini, M. (author), Draper, E. (author), Halvorsen, T. (author), Johnson, S. (author), Källén, K. (author), Land, T. (author), Lebeer, J. (author), Lehtonen, L. (author), Maier, R.F. (author), Marlow, N. (author), Morgan, A. (author), Ni, Y. (author), Raikkonen, K. (author), Rtimi, A. (author), Sarrechia, I. (author), Varendi, H. (author), Vollsaeter, M. (author), Wolke, D. (author), Ylijoki, M. (author), Zeitlin, J. (author)Background: Studies are sparse and inconclusive about the association between maternal education and cognitive development among children born very preterm (VPT). Although this association is well established in the general population, questions remain about its magnitude among children born VPT whose risks of medical and developmental...article 2021
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van Gemert, Y. (author), Kozijn, A.E. (author), Pouwer, M.G. (author), Kruisbergen, N.N.L. (author), van den Bosch, M.H.J. (author), Blom, A.B. (author), Pieterman, E.J. (author), Weinans, H. (author), Stoop, R. (author), Princen, H.M.G. (author), van Lent, P.L.E.M. (author)Objective: High systemic cholesterol levels have been associated with osteoarthritis (OA) development. Therefore, cholesterol lowering by statins has been suggested as a potential treatment for OA. We investigated whether therapeutic high-intensive cholesterol-lowering attenuated OA development in dyslipidemic APOE*3Leiden.CETP mice. Methods:...article 2021
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Vooijs, M. (author), Bossen, D. (author), Hoving, J.L. (author), Wind, H. (author), Frings-Dresen, M.H.W. (author)Background: A guideline for occupational health professionals (OHPs) is developed which provides them with knowledge and skills to optimize their guidance to people with a chronic disease. Objective: Developing a training programme to acquire and apply knowledge and skills provided by the guideline, through a bottom-up approach. Methods: First,...article 2021
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van Dijk, T. (author), Kater, A. (author), Jansen, M. (author), Dondorp, W.J. (author), Blom, M. (author), Kemp, S. (author), Langeveld, M. (author), Cornel, M.C. (author), van der Pal, S.M. (author), Henneman, L. (author)Neonatal bloodspot screening (NBS) aims to detect treatable disorders in newborns. The number of conditions included in the screening is expanding through technological and therapeutic developments, which can result in health gain for more newborns. NBS expansion, however, also poses healthcare, ethical and societal challenges. This qualitative...article 2021
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Kater-Kuipers, A. (author), van Dijk, T. (author), Wins, S. (author), van der Pal, S.M. (author), Henneman, L. (author)Met de hielprik wordt het bloed onderzocht op een aantal ziektes. Dit zijn ziektes die niet veel baby’s hebben, maar die wel ernstig zijn. Als deze ziektes tijdig worden ontdekt, kan de behandeling snel starten. De gevolgen van de ziekte zijn dan minder erg. De ZonMw PANDA-studie heeft onderzocht wat ouders en professionals van de huidige...other 2021
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de Mooij, B. (author), Fekkes, M. (author), Scholte, R.H.J. (author), Overbeek, G. (author)Social skills training (SST) programs for nonclinical children and adolescents are known to have positive effects on social skills, but it remains unclear how distinct training components are related to program effects. This multilevel meta-analysis examines how psychoeducation (i.e., exercises aimed at the transfer of knowledge), psychophysical...article 2020
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Vink, R. (author), de Wolff, M. (author), Broerse, A. (author), Kamphuis, M. (author)Ook de richtlijn Kindermishandeling is geactualiseerd. Sinds de eerste publicatie van de richtlijn in 2016 is er veel veranderd in de aanpak van kindermishandeling. De richtlijn is aangevuld met nieuwe onderzoeksresultaten en nieuwe interventies. Verder hebben ervaringen met het gebruik van de richtlijn geleid tot verbeteringen. Deze richtlijn...report 2020
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van der Valk, M.A. (author), Schuller, A.A. (author), Reyners, A.K.L. (author)In this questionnaire study, the attitude of dentists and students regarding the provision of oral care to palliative patients was investigated. The extent to which they would like to be involved in the care for this patient group was also investigated. The results showed that both research groups had relatively little affinity with palliative...article 2020
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van Vianen, A.E.M. (author), de Pater, I.E. (author), Preenen, P.T.Y. (author)The changing labour market and unpredictability of careers necessitate employees to adopt non-traditional norms of career success and assess their career in terms of employability. We propose that employees could promote their employability specifically through engagement in challenging work experiences. High quality jobs provide employees with...bookPart 2020
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Schuller, A.A. (author), Vermaire, J.H. (author), Verrips, G.H.W. (author)In this third article in a series of 5 in the context of the 2017 Kies-voor-Tanden Study, the results for the 11-year-olds are presented. The study was conducted among 11-year-olds who lived in Alphen aan den Rijn, Gouda, Breda or Den Bosch and consisted of a clinical oral examination and a questionnaire completed by both them and their parents....article 2020
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Schuller, A.A. (author), Vermaire, J.H. (author), Verrips, G.H.W. (author)This fifth and final in a series of 5 articles in the context of the 2017 Kies-voor-Tanden study presents the results for 23-year-olds. 21% of the 23-year-olds had flawless permanent teeth. In 2017, there were still differences in oral health among the socio-economic (SES) groups, to the advantage of the high SES group. The oral health of the...article 2020
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van Kesteren, N. (author), Wildeman, I. (author), Oprins-van Liempd, F. (author), van Harten, L. (author)Binnen de jeugdgezondheidszorg (JGZ) stijgt de vraag naar digitale zorg en hulpverlening (eHealth). Een voorbeeld hiervan is blended care, wat verwijst naar een combinatie van online en offline behandelingen en contacten. Na beperkte resultaten in het gebruik van blended care-modules rondom excessief huilen en pesten is onderzocht welke...article 2020
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Vink, R. (author), de Wolff, M. (author), Broerse, A. (author), Kamphuis, M. (author)Deze richtlijn is niet zomaar een richtlijn. Kindermishandeling is een complex probleem zonder één duidelijke oorzaak en zonder één duidelijke oplossing. Als jeugdprofessional werk je met ouders samen en ben je er voor de veiligheid van jeugdigen. Toch moet je ouders soms ook vertellen dat je je over die veiligheid heel erg zorgen maakt. En dat...report 2020
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Koopman, A.S. (author), Kingma, I. (author), de Looze, M.P. (author), van Dieën, J.H. (author)Low-back pain is the number one cause of disability in the world, with mechanical loading as one of the major risk factors. Exoskeletons have been introduced in the workplace to reduce low back loading. During static forward bending, exoskeletons have been shown to reduce back muscle activity by 10% to 40%. However, effects during dynamic...article 2020
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Pouwer, M.G. (author), Pieterman, E.J. (author), Worms, N. (author), Keijzer, N. (author), Jukema, J.W. (author), Gromada, J. (author), Gusarova, V. (author), Princen, H.M.G. (author)Atherosclerosis-related cardiovascular disease causes nearly 20 million deaths annually. Most patients are treated after plaques develop, so therapies must regress existing lesions. Current therapies reduce plaque volume, but targeting all apoB-containing lipoproteins with intensive combinations that include alirocumab or evinacumab-monoclonal...article 2020