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document
Tooke, J.E. (author), Shore, A.C. (author), Cohen, R.A. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)
article 1996
document
Boelsma, E. (author), Brink, E.J. (author), Stafleu, A. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
The general feeling of wellness after food consumption may play an important role in regulating food intake. This exploratory study aimed at identifying and evaluating measures of such postprandial wellness, tentatively defined as subjective appreciation of life after food intake. The study had a randomized cross-over, double blind design....
article 2010
document
van Bergen, S. (author), Wang, M. (author), TNO Voeding (author)
article 2002
document
Punt, P.J. (author), Strauss, J. (author), Smit, R. (author), Kinghorn, J.R. (author), van den Hondel, C.A.M.J.J. (author), Scazzocchio, C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1995
document
Moerman, C.J. (author), TNO Preventie en gezondheid (author)
article 1996
document
Kaptein, A. (author), Roodenburg, L. (author), Princen, H.M.G. (author), Gaubius Institute TNO Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Addition of sodium butyrate to the culture medium of the human hepatoma cell line Hep G2 resulted in a time- and dose-dependent increase in the secretion of apolipoprotein A-I (apo A-I) and apolipoprotein B100 (apo B100). After a 24 h preincubation period, a 2.4- and 2.2-fold increase in the secretion of apo A-I and apo B100 respectively was...
article 1991
document
Foti, M.J. (author), Médici, R. (author), Ruijssenaars, H.J. (author)
Pseudomonas putida S12 was engineered for the production of monoethanolamine (MEA) from glucose via the decarboxylation of the central metabolite l-serine, which is catalyzed by the enzyme l-serine decarboxylase (SDC).The host was first evaluated for its tolerance towards MEA as well as its endogenous ability to degrade this alkanolamine. Growth...
article 2013
document
Visser, H. (author), Joosten, V. (author), Punt, P.J. (author), Gusakov, A.V. (author), Olson, P.T. (author), Joosten, R. (author), Bartels, J. (author), Visser, J. (author), Sinitsyn, A.P. (author), Emalfarb, M.A. (author), Verdoes, J.C. (author), Wery, J. (author)
The filamentous fungus C1 was developed into an expression platform for screening and production of diverse industrial enzymes. C1 shows a lowviscosity morphology in submerged culture, enabling the use of complex growth and production media. This morphology furthermore allowed C1 to be used as a host for high-throughput robotic screening of gene...
article 2011
document
Chen, C.-T. (author), Burton-Wurster, N. (author), Lust, G. (author), Bank, R.A. (author), Tekoppele, J.M. (author)
The first objective of this study was to determine if the cumulative effects of impact or smoothly arising compression would damage the matrix of articular cartilage. Canine cartilage explants were subjected to repeated impacts or to smoothly arising compressions of as much as 20 MPa at 0.3 Hz for as long as 120 minutes. An increase in the water...
article 1999
document
Hogervorst, J.G.F. (author), Baars, B.-J. (author), Schouten, L.J. (author), Konings, E.J.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Since 2002, it is known that the probable human carcinogen acrylamide is present in commonly consumed carbohydrate-rich foods, such as French fries and potato chips. In this review, the authors discuss the body of evidence on acrylamide carcinogenicity from both epidemiological and rodent studies, including variability, strengths and weaknesses,...
article 2010
document
Hooisma, J. (author), Dam, E.W. (author), Medisch Biologisch Laboratorium TNO (author)
Chemicals/CAS: 2 hexanone, 591-78-6; acetonylacetone, 110-13-4; hexane, 110-54-3
article 1981
document
Kitayama, K. (author), Nakai, D. (author), Kono, K. (author), van der Hoop, A.G. (author), Kurata, H. (author), de Wit, E.C. (author), Cohen, L.H. (author), Inaba, T. (author), Kohama, T. (author), TNO Preventie en Gezondheid (author)
1-{7-[(1-(3,5-Diethoxyphenyl)-3-{[(3,5-difluorophenyl)(ethyl)amino]carbo nyl}-4-oxo-1,4-dihydroquinolin-7-yl)oxy]heptyl}-1-methylpiperidinium bromide, R-146224, is a potent, specific ileum apical sodium-dependent bile acid transporter (ASBT) inhibitor; concentrations required for 50% inhibition of [3H]taurocholate uptake in human ASBT-expressing...
article 2006
document
de Vries, M.J. (author), Medisch Biologisch Laboratorium TNO (author)
article 1958
document
Blaauboer, M.E. (author), Emson, C.L. (author), Verschuren, L. (author), van Erk, M. (author), Turner, S.M. (author), Everts, V. (author), Hanemaaijer, R. (author), Stoop, R. (author)
Collagen deposition is a key process during idiopathic pulmonary fibrosis; however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily available and it is difficult to identify changes in collagen content, since standard collagen analyses do not...
article 2013
document
van der Schans, G.P. (author), Medisch Biologisch Laboratorium TNO (author)
The induction of single- and double-strand breaks in DNA by γ-rays has been measured. The maximum number of nucleotide paris (a) between two independently induced single-strand breaks in opposite strands of the DNA which cannot prevent the occurrence of a double-strand break was found to amount to about 16. This value did not differ...
article 1978
document
Voshol, P.J. (author), Rensen, P.C.N. (author), van Dijk, K.W. (author), Romijn, J.A. (author), Havekes, L.M. (author), TNO Kwaliteit van Leven (author)
The obesity epidemic is associated with an increased incidence of type 2 diabetes, cardiovascular morbidity and various types of cancer. A better insight into the molecular mechanisms that underlie adipogenesis and obesity may result in novel therapeutic handles to fight obesity and these associated diseases. Adipogenesis is determined by the...
article 2009
document
Boelens, M.H. (author), Boelens, H. (author), van Gemert, L.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1995
document
Atuonwu, J.C. (author), van Straten, G. (author), van Deventer, H.C. (author), van Boxtel, A.J.B. (author)
This work presents a mixed integer nonlinear programming (MINLP) formulation for the design of energy-efficient multistage adsorption dryers within constraints on product temperature and moisture content. Apart from optimizing temperatures and flows, the aim is to select the most efficient adsorbent per stage and product to air flow...
article 2012
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Wang, Y. (author), Xu, H. (author), Wei, X. (author), Chai, C. (author), Xiao, Y. (author), Zhang, Y. (author), Chen, B. (author), Xiao, G. (author), Ouwerkerk, P.B.F. (author), Wang, M. (author), Zhu, Z. (author), TNO Kwaliteit van Leven (author)
Monosaccharide transporters mediate the membrane transport of a variable range of monosaccharides, which plays a crucial role in sugar distribution throughout the plant. To investigate the significance of monosaccharide transporters for rice (Oryza sativa L.) seed development, cDNA of a new putative monosaccharide transporter gene OsMST4 was...
article 2007
document
Ahmadi-Abhari, S. (author), Woortman, A.J.J. (author), Hamer, R.J. (author), Oudhuis, A.A.C.M. (author), Loos, K. (author)
Starch is an omnipresent constituent which is used for its nutritional and structuring properties. Recently concerns have been raised since starch is a source of readily available glucose which is tightly correlated with diabetes type II and obesity. For this reason, the possibilities for modulating the digestibility of starch while preserving...
article 2013
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