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van Doorn, M. (author), Vogels, J. (author), Tas, A. (author), van Hoogdalem, E.J. (author), Burggraaf, J. (author), Cohen, A. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
Aims: To explore the usefulness of metabolomics as a method to obtain a broad array of biomarkers for the pharmacological effects of rosiglitazone (RSG) in plasma and urine samples from patients with type 2 diabetes mellitus (T2DM) and healthy volunteers (HVs). Additionally, we explored the differences in metabolite concentrations between T2DM...
article 2007
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Brandt, E. (author), Buitendijk, S. (author), Vogels, T. (author), TNO Kwaliteit van Leven (author)
Moderne software en hardware; goede geautomatiseerde processen zijn daarbij onontbeerlijk. Maar tussen droom en daad staan wetten in de weg, en praktische bezwaren. In deze publicatie wordt openhartig gesproken over ict-projecten in de zorg van TNO, de Engelse National Health Service(NHS) en Kaiser Permanente, de grootste zorgaanbieder van de...
report 2007
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Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.P.H.T.M. (author), Horbach, G.J. (author), Smit, M.J. (author), Zandberg, P. (author), Mellema, J.R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)
1H nuclear magnetic resonance (NMR) spectroscopy of rat urine in combination with pattern recognition analysis was evaluated for early noninvasive detection of toxicity of investigational chemical entities. Bromobenzene (B) and paracetamol (P) were administered at five single oral dosages between 2 and 500 mg/kg and between 6 and 1800 mg/kg,...
article 2007
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Verrips, E. (author), Vogels, T. (author), Crone, M.R. (author), Wagenaar-Fischer, M.M. (author), van Velzen, H. (author), Buitendijk, S.E. (author), Hille, E. (author), van der Pal, K. (author), Ory, F. (author), van Buuren, S. (author), TNO Kwaliteit van Leven (author)
report 2007
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Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.-P.H.T.M. (author), Smit, M.J. (author), Zandberg, P. (author), Horbach, G.J. (author), Mellema, J.-R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)
A procedure of nuclear magnetic resonance (NMR) urinalysis using pattern recognition is proposed for early detection of toxicity of investigational compounds in rats. The method is applied to detect toxicity upon administration of 13 toxic reference compounds and one nontoxic control compound (mianserine) in rats. The toxic compounds are...
article 2007
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de Jonge, A. (author), Korfker, D.G. (author), Vogels, T. (author), van der Pal, S.M. (author), Vink, R.M. (author), Buitendijk, S.E. (author), van der Pal-de Bruin, K.M. (author), TNO Kwaliteit van Leven (author)
JGB, V&P. Kraamverzorgenden kunnen een belangrijke rol spelen bij het signaleren van jonge gezinnen die ondersteuning nodig hebben. Zij maken een gezin langer mee dan andere jeugdhulpverleners en kunnen daardoor in vroeg stadium signalen oppikken die mogelijk tot problemen voor het kind en het gezin kunnen leiden. Dat concluderen onderzoekers...
report 2007
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Grootenhuis, M.A. (author), Koopman, H.M. (author), Verrips, G.H.W. (author), Vogels, A.G.C. (author), Last, B.F. (author), TNO Kwaliteit van Leven (author)
In paediatric research, Health-Related Quality-of-Life (HRQoL) has received increasing recognition as an important health outcome. This study aimed to investigate the nature and prevalence of HRQoL problems in children with different chronic diseases. Data were available on 318 children aged 8-11 years with different diseases: congenital heart...
article 2007
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Fekkes, M. (author), Pijpers, F.I.M. (author), Fredriks, A.M. (author), Vogels, T. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)
OBJECTIVES. A number of studies have shown that victimization from bullying behavior is associated with substantial adverse effects on physical and psychological health, but it is unclear which comes first, the victimization or the health-related symptoms. In our present study, we investigated whether victimization precedes psychosomatic and...
article 2006
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Reijneveld, S.A. (author), Vogels, A.G.C. (author), Hoekstra, F. (author), Crone, M.R. (author), TNO Kwaliteit van Leven (author)
article 2006
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Vogels, A.G.C. (author), Jacobusse, G.W. (author), Chablani, R.K.K.R. (author), Rövekamp, A.J.M. (author), Hilgersom, M.J.C. (author), Reijneveld, S.A. (author), TNO Kwaliteit van Leven (author)
report 2006
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Vogels, A.G.C. (author), Crone, M.R. (author), Hoekstra, F. (author), Reijneveld, S.A. (author), TNO Kwaliteit van Leven (author)
report 2005
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Hille, E.T.M. (author), den Ouden, A.L. (author), Stuifbergen, M.C. (author), Verrips, G.H.W. (author), Vogels, A.G.C. (author), Brand, R. (author), Gravenhorst, J.B. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)
Aim: To assess whether attrition rate influences outcome in the follow-up of very preterm infants. Study design: In a national follow-up study of infants born alive in 1983 in the Netherlands with a gestational age less than 32 weeks and/or a birth weight less than 1500 g, outcome was assessed separately for adolescents who responded early or...
article 2005
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Reijneveld, S.A. (author), Vogels, A.G.C. (author), TNO Kwaliteit van Leven (author)
bookPart 2005
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Detmar, S.B. (author), Hosli, E.J. (author), Chorus, A.M.J. (author), van Beekum, T. (author), Vogels, T. (author), Mourad-Baars, P.E.C. (author), Engelberts, A.C. (author), Groothuis - Oudshoorn, C.G.M. (author), Verrips, G.H.W. (author)
Introduction: This paper describes the development and initial psychometric evaluation of the Handicap Scale for Children (HSC). This questionnaire is based on the London Handicap Scale (LHS), a valid and reliable utility instrument for measuring social participation in adults. Methods: A multidisciplinary research group was involved in...
article 2005
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Vogels, A.G.C. (author), Crone, M.R. (author), Hoekstra, F. (author), Reijneveld, S.A. (author), TNO Kwaliteit van Leven (author)
report 2005
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Kamphuis, M. (author), Vliegen, H.W. (author), Verloove-Vanhorick, S.P. (author), Ottenkamp, J. (author), Vogels, T. (author)
Objective. To evaluate employment, career problems and job-related handicaps in adults with complex or mild congenital heart disease (CHD). Design. Cross-sectional. Method. Data were obtained from 76 patients with complex and 80 with mild CHD who were known to the Department of Paediatric Cardiology at the Leiden University Medical Center, the...
article 2005
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Clish, C.B. (author), Davidov, E. (author), Oresic, M. (author), Plasterer, T.N. (author), Lavine, G. (author), Londo, T. (author), Meys, M. (author), Snell, P. (author), Stochaj, W. (author), Adourian, A. (author), Zhang, X. (author), Morel, N. (author), Neumann, E. (author), Verheij, E. (author), Vogels, J.T.W.E. (author), Havekes, L.M. (author), Afeyan, N. (author), Regnier, F. (author), van der Greef, J. (author), Naylor, S. (author), TNO Preventie en Gezondheid (author)
Integrative (or systems biology) is a new approach to analyzing biological entities as integrated systems of genetic, genomic, protein, metabolite, cellular, and pathway events that are in flux and interdependent. Here, we demonstrate the application of intregrative biological analysis to a mammalian disease model, the apolipoprotein E3-Leiden ...
article 2004
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Bruil, J. (author), Fekkes, M. (author), Vogels, T. (author), Verrips, G.H.W. (author), TNO Preventie en Gezondheid (author)
Dit zijn de TACQOL bestanden >15 jaar. Behorende bij de vragenlijst TACQOL.
other 2004
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Orešič, M. (author), Clish, C.B. (author), Davidov, E.J. (author), Verheij, E. (author), Vogels, J. (author), Havekes, L.M. (author), Neumann, E. (author), Adourian, A. (author), Naylor, S. (author), van der Greef, J. (author), Plasterer, T. (author), TNO Preventie en Gezondheid (author)
Multifactorial diseases present a significant challenge for functional genomics. Owing to their multiple compartmental effects and complex biomolecular activities, such diseases cannot be adequately characterised by changes in single components, nor can pathophysiological changes be understood by observing gene transcripts alone. Instead, a...
article 2004
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Davidov, E. (author), Clish, C.B. (author), Oresic, M. (author), Meys, M. (author), Stochaj, W. (author), Snell, P. (author), Lavine, G. (author), Londo, T.R. (author), Adourian, A. (author), Zhang, X. (author), Johnston, M. (author), Morel, N. (author), Marple, E.W. (author), Plasterer, T.N. (author), Neumann, E. (author), Verheij, E. (author), Vogels, J.T.W.E. (author), Havekes, L.M. (author), van der Greef, J. (author), Naylor, S. (author), TNO Preventie en Gezondheid (author)
Multitiered quantitative analysis of biological systems is rapidly becoming the desired approach to study hierarchical functional interactions between proteins and metabolites. We describe here a novel systematic approach to analyze organisms with complex metabolic regulatory networks. By using precise analytical methods to measure biochemical...
article 2004
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