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Haider, A.W. (author), Andreotti, F. (author), Hackett, D.R. (author), Tousoulis, D. (author), Kluft, C. (author), Maseri, A. (author), Davies, G.J. (author), Gaubius Instituut TNO (author)Objectives. This study investigated the influence of early spontaneous intermittent reperfusion on the extent of myocardial damage and its relation to endogenous hemostatic activity, Background. In the early phase of acute myocardial infarction coronary occlusion is often intermittent, even before thrombolytic therapy is administered. The...article 1995
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Odink, J. (author), Zuiderwijk, P.B.M. (author), Schoen, E.D. (author), Gan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This study was designed to investigate local reactions after the intracutaneous (i.c.) administration of two human menopausal gonadotrophin preparations. For this purpose, 20 healthy female volunteers received six i.c. injections simultaneously, viz. three different batches of both Humegon (Organon, Oss, The Netherlands) and Pergonal (Serono,...article 1995
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Myrup, B. (author), Hansen, P.M. (author), Jensen, T. (author), Kofoed-Enevoldsen, A. (author), Feldt-Rasmussen, B. (author), Gram, J. (author), Kluft, C. (author), Jespersen, J. (author), Deckert, T. (author), Gaubius Instituut TNO (author)We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low...article 1995
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van Poppel, G. (author), Hospers, J. (author), Nieuwenhuizen, W. (author), Laterveer, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A high intake of β-carotene has been associated with a decreased risk for cardiovascular disease. To evaluate whether β-carotene may exert a protective effect through an impact on haemostasis a randomized, placebo-controlled trial was conducted in male smokers (n = 149) using 20 mg/day β-carotene for 14 weeks. For comparisons, haemostatic...article 1995
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Hirasing, R.A. (author), Verrips, G.H. (author), Burgmeijer, R.J.F. (author), Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author)Objective. To establish the participation in a number of effective prevention programmes for infants of Turkish, Maroccan, Chinese and Vietnamese inhabitants of the four major cities in the Netherlands. Design. Enquiry. Setting. Health centres in Amsterdam, Rotterdam, The Hague and Utrecht. Method. Health centre staff members in 1994 asked 194...article 1995
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Kardinaal, A.F.M. (author), Aro, A. (author), Kark, J.D. (author), Riemersma, R.A. (author), van 't Veer, P. (author), Gomez-Aracena, J. (author), Kohlmeier, L. (author), Ringstad, J. (author), Martin, B.C. (author), Mazaev, V.P. (author), Delgado-Rodriguez, M. (author), Thamm, M. (author), Huttunen, J.K. (author), Martin-Moreno, J.M. (author), Kok, F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Because antioxidants may play a role in the prevention of coronary heart disease by inhibiting the peroxidation of polyunsaturated fatty acids (PUFAs), the combined association of diet-derived antioxidants and PUFAs with acute myocardial infarction (MI) was investigated. This multicenter case- control study included 674 patients and 725 control...article 1995
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Theuns, H.M. (author), TNO Preventie en Gezondheid (author)In this article the importance of mineral suppletion for teeth and jawbone is explained in a step-wise manner. The steps discussed are the pre-eruptive phase of teeth and the growth, adult and ageing phase of the skeleton. Mineral suppletion should be seen as a measure to prevent dental caries (fluoride) and to ensure a maximal resistance...article 1995
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Velthuis-te Wierik, E.J.M. (author), van Leeuwen, R.E.W. (author), Hendriks, H.F.J. (author), Verhagen, H. (author), Loft, S. (author), Poulsen, H.E. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Restriction of energy intake (ER), without malnutrition of essential nutrients, has repeatedly been demonstrated to increase longevity in rodents. In the antioxidant theory of aging the lack of balance between the generation of free radicals and free radical scavenging was thought to be a main causal agent in the aging process. From this point...article 1995
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Otter, M. (author), Kuiper, J. (author), Rijken, D. (author), van Zonneveld, A.-J. (author), TNO Preventie en Gezondheid (author)To characterize the primary structure of rat Vn, a cDNA library constructed from freshly isolated rat hepatocytes, was screened with a human Vn cDNA probe. Comparison of the sequence of the obtained rat cDNA clone with the sequences of human, mouse and rabbit Vn cDNA's showed predominantly consensus in the somatomedin B domain, the RGD-sequence...article 1995
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Kalsbeek, H. (author), van Tiel, J.P. (author), Verrips, G.H. (author), Poorterman, J.H. (author)In order to evaluate the results of Regional Institutions (RI's) for Youth Dentistry, an epidemiological study was performed on caries experience and oral hygiene habits of 5-, 8- and 11-year-olds, getting dental treatment in these institutions. In the big cities participants of the RI's appeared to be mostly from the lower social levels of...article 1994
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Smits, R.C.F. (author), Emmen, H.H. (author), Bertelmans, F.W. (author), Kulig, B.M. (author), van Loenen, A.C. (author), Polman, C.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could...article 1994
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Verrips, G.H. (author), Kalsbeek, H. (author), Frencken, J.E. (author), TNO Preventie en Gezondheid (author)Public Health insurance provision of dental care for patients with a physical, mental, dental or medical handicap has been reorganized in 1990. In order to evaluate this reorganization, general dental practitioners, dentists in hospital clinics or institutions for the handicapped as well as dentists employed as advisors to local health insurance...article 1994
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Nijhuis, E. (author), Hinloopen, B. (author), van Duijn, C. (author), Hofman, A. (author), Rozing, J. (author), Nagelkerken, L. (author), Section of Immunology, Inst. of Aging and Vascular Research, TNO, Leiden, Netherlands TNO Preventie en Gezondheid (author)Cortisol levels in patients with Alzheimer's disease (AD) are relatively unaffected by a challenge with dexamethasone (DEX) in vivo. The present study demonstrates that DEX is less inhibitory for phytohemagglutinin (PHA)-induced T cell proliferation in AD patients as compared to age-matched controls. Since no significant differences were found...article 1994
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Gaubius Instituut TNO (author), van der Mooren, M.J. (author), Gevers Leuven, J.A. (author), Rolland, R. (author)Objective: To study the possible changes in serum lipids and lipoproteins during hormone replacement therapy with special emphasis on the possible effects brought about by the progestogen. Design: Open-label randomized prospective comparative study. Setting: Gynecological outpatient department of a university hospital. Patients: Thirty-three...article 1994
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Verrips, G.H. (author), Kalsbeek, H. (author)This article reviews the literature on child dental caries in various ethnic groups in the Netherlands. Material from fifteen studies showed generally the dental health of five- to eleven-year-old children of parents born in Turkey or Morocco to be far worse than that of children of Dutch or Surinamese parents. The ethnic groups distinguished,...article 1993
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Verrips, G.H. (author), Kalsbeek, H. (author), Frencken, J.E. (author), ter Horst, G. (author), Filedt Kok-Weimar, T.L. (author)A previous study has shown five-year-old children of parents originating from Turkey or Morocco to have twice as much dmfs as children of parents from The Netherlands, Surinam or various other countries. In the present study, other risk indicators and factors for the prevalence of caries amongst these children were studied by interviewing their...article 1993
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- Verloove-Vanhorick, S.P. (author), TNO Preventie en Gezondheid (author) article 1993
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Meulmeester, J.F. (author), Hulshof, K.F.A.M. (author)Migration might have considerable implications for nutrition and consequently for health. Because of the higher demands of growth, children are especially vulnerable to changes in nutrition. In order to get an insight into the need for a special nutrition policy for Turkish ad Moroccan children, the dietary habits and food consumption of 8-year...article 1993
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Verrips, G.H. (author), Kalsbeek, H. (author), Eijkman, M.A. (author)The aim of this study was to assess differences in oral health and dental behaviour in a cohort of five-year-old children born in 1982 and a cohort of eleven-year-old children born in 1976, in different ethnic and socio-economic groups, in the period from 1987 to 1990. To this end a secondary analysis was performed on data collected in a study...article 1993
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Schuurs, A.H.B. (author), Verrips, G.H. (author), TNO Preventie en Gezondheid (author)Some information is given on the number of dentists in Turkey and Morocco and the dental condition of the inhabitants. This information concerns prevention, caries, periodontic diseases as well as other dental diseases and diseases of the mouth.article 1993