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Bourgonje, A.R. (author), Offringa, A.K. (author), van Eijk, L.E. (author), Abdulle, A.E. (author), Hillebrands, J.L. (author), van der Voort, P.H.J. (author), van Goor, H. (author), van Hezik, E.J. (author)Significance: Hydrogen sulfide (H2S) is one of the three main gasotransmitters that are endogenously produced in humans and are protective against oxidative stress. Recent findings from studies focusing on coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), shifted our attention to a...article 2021
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Krishnan, S. (author), Vermeulen, R. (author), Pronk, A. (author), Gyori, B.M. (author), Bachman, J.A. (author), Vlaanderen, J. (author), Stierum, R. (author)BACKGROUND: Mechanistic data is increasingly used in hazard identification of chemicals. However, the volume of data is large, challenging the efficient identification and clustering of relevant data. OBJECTIVES: We investigated whether evidence identification for hazard assessment can become more efficient and informed through an automated...article 2022
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van Egmond, M.B. (author), Spini, G. (author), van der Galien, O. (author), IJpma, A. (author), Veugen, P.J.M. (author), Kaaij, W. (author), Sangers, A. (author), Rooijakkers, T. (author), Langenkamp, P. (author), Kamphorst, B. (author), van de L'Isle, N. (author), Kooij-Janic, M. (author)Background: Recent developments in machine learning have shown its potential impact for clinical use such as risk prediction, prognosis, and treatment selection. However, relevant data are often scattered across diferent stakehold ers and their use is regulated, e.g. by GDPR or HIPAA. As a concrete use-case, hospital Erasmus MC and health...article 2021
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TNO Kwaliteit van Leven (author), Boelsma, E. (author), Kloek, J. (author)Background. Milk derived peptides have been identified as potential antihypertensive agents. The primary objective was to investigate the effectiveness of IPP-rich milk protein hydrolysates (MPH) on reducing blood pressure (BP) as well as to investigate safety parameters and tolerability. The secondary objective was to confirm or falsify ACE...article 2010
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TNO Kwaliteit van Leven (author), de Vreede, P.L. (author), van Meeteren, N.L. (author), Samson, M.M. (author), Wittink, H.M. (author), Duursma, S.A. (author), Verhaar, H.J. (author)Background: Data regarding the effect of exercise programmes on older adults' health-related quality of life (HRQOL) and habitual physical activity are inconsistent. Objective: To determine whether a functional tasks exercise programme (enhances functional capacity) and a resistance exercise programme (increases muscle strength) have a different...article 2006
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Cavallera, V. (author), Lancaster, G. (author), Gladstone, M. (author), Black, M.M. (author), McCray, G. (author), Nizar, A. (author), Ahmed, S. (author), Dutta, A. (author), Anago, R.K.E. (author), Brentani, A. (author), Jiang, F. (author), Schönbeck, Y. (author), McCoy, D.C. (author), Kariger, P. (author), Weber, A.M. (author), Raikes, A. (author), Waldman, M. (author), van Buuren, S. (author), Kaur, R. (author), Pérez Maillard, M. (author), Nisar, M.I. (author), Khanam, R. (author), Sazawal, S. (author), Zongo, A. (author), Pacifico Mercadante, M. (author), Zhang, Y. (author), Roy, A.D. (author), Hepworth, K. (author), Fink, G. (author), Rubio-Codina, M. (author), Tofail, F. (author), Eekhout, I. (author), Seiden, J. (author), Norton, R. (author), Baqui, A.H. (author), Ali, J.K. (author), Zhao, J. (author), Holzinger, A. (author), Detmar, S. (author), Kembou, S.N. (author), Begum, F. (author), Ali, S.M. (author), Jehan, F. (author), Dua, T. (author), Janus, M. (author)Introduction Children's early development is affected by caregiving experiences, with lifelong health and well-being implications. Governments and civil societies need population-based measures to monitor children's early development and ensure that children receive the care needed to thrive. To this end, the WHO developed the Global Scales for...article 2023
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Gaubius instituut TNO (author), de Maat, M.P.M. (author), Jukema, J.W. (author), Ye, S. (author), Zwinderman, A.H. (author), Moghaddam, P.H. (author), Beekman, M. (author), Kastelein, J.J.P. (author), van Boven, A.J. (author), Bruschke, A.V.G. (author), Humphries, S.E. (author), Kluft, C. (author), Henney, A.M. (author)It has proved difficult to identify high-risk patients for atherosclerosis and to determine how they might respond to medication. Recently, a common promoter variant of the human stromelysin-1 gene has been reported, which has been shown to affect the transcription. We investigated whether this polymorphism had any impact on the risk of events,...article 1999
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TNO Preventie en Gezondheid NIA TNO (author), Miedema, H.S. (author), Chorus, A.M.J. (author), Wevers, C.W.J. (author), van der Linden, S. (author)Study Design. A follow-up study of a cohort of 444 patients aged 16 to 59 years who consulted with their general practitioners (GPs) in 1987-1988 for an incident episode of back pain. Objectives. To determine the proportion of patients with back pain in whom chronic back problems develop after a follow-up of 7 years, to compare health outcomes...article 1998
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Gaubius Instituut TNO (author), van der Mooren, M.J. (author), Gevers Leuven, J.A. (author), Rolland, R. (author)Objective: To study the possible changes in serum lipids and lipoproteins during hormone replacement therapy with special emphasis on the possible effects brought about by the progestogen. Design: Open-label randomized prospective comparative study. Setting: Gynecological outpatient department of a university hospital. Patients: Thirty-three...article 1994
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Gaubius Instituut TNO (author), van de Poll, S.W.E. (author), Delsing, D.J.M. (author), Jukema, J.W. (author), Princen, H.M.G. (author), Havekes, L.M. (author), Puppels, G.J. (author), van der Laarse, A. (author)Combined treatment of statins and calcium channel blockers has been suggested to be superior to statin therapy alone. We quantified the anti-atherosclerotic potential of amlodipine, atorvastatin and their combination on existing atherosclerotic plaques in the aorta of APOE*3-Leiden transgenic mice. Sixty-two mice were fed a high cholesterol...article 2003
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TNO Arbeid (author), Weiss, J.J. (author), Mulder, C.L. (author), Antoni, M.H. (author), Vroome, E.M.M.de (author), Garssen, B. (author), Goodkin, K. (author)Background: This study compared the effects of a supportive-expressive group intervention (GI) with an educational control condition (EC) on long-term psychosocial adjustment in gay men with HIV infection. Method: Subjects (n = 85) were randomized after stratification for disease stage and use of antiretroviral medication. GI consisted of 4...article 2003
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TNO Kwaliteit van Leven (author), Trion, A. (author), Maat, M.de (author), Jukema, W. (author), Maas, A. (author), Offerman, E. (author), Havekes, L. (author), Szalai, A. (author), Laarse, A.V.D. (author), Princen, H. (author), Emeis, J. (author)We investigated the pleiotropic effects of a calcium antagonist (amlodipine) on early atherosclerosis development in the presence and absence of an HMG-CoA-reductase inhibitor (atorvastatin) in apolipoprotein E*3-Leiden/human C-reactive protein (E3L/CRP) transgenic mice. Male E3L/CRP transgenic mice were fed a cholesterol-containing diet either...article 2006
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TNO Kwaliteit van Leven (author), Ceconi, C. (author), Fox, K.M. (author), Remme, W.J. (author), Simoons, M.L. (author), Bertrand, M. (author), Parrinello, G. (author), Kluft, C. (author), Blann, A. (author), Cokkinos, D. (author), Ferrari, R. (author)Objectives: EUropean trial on Reduction Of cardiac events with Perindopril in stable coronary Artery disease [EUROPA] demonstrates reduction in cardiovascular mortality and myocardial infarction for a possible vascular and antiatherosclerotic effect of angiotensin-converting enzyme (ACE) inhibition with perindopril. Our objective was to study...article 2007
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TNO Kwaliteit van Leven (author), Lemckert, A.A.C. (author), Grimbergen, J. (author), Smits, S. (author), Hartkoorn, E. (author), Holterman, L. (author), Berkhout, B. (author), Barouch, D.H. (author), Vogels, R. (author), Quax, P. (author), Goudsmit, J. (author), Havenga, M.J.E. (author)Recombinant adenoviral vectors based on type 5 (rAd5) show great promise as a vaccine carrier. However, neutralizing activity against Ad5 is prevalent and high-titred among human populations, and significantly dampens Ad5-based vaccine modalities. The generation of alternative adenoviral vectors with low seroprevalence thus receives much...article 2006
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TNO Kwaliteit van Leven (author), Steenvoorden, M.M.C. (author), Huizinga, T.W.J. (author), Verzijl, N. (author), Bank, R.A. (author), Ronday, H.K. (author), Luning, H.A.F. (author), Lafeber, F.P.J.G. (author), Toes, R.E.M. (author), de Groot, J. (author)Objective. The major risk factor for osteoarthritis (OA) is aging, but the mechanisms underlying this risk are only partly understood. Age-related accumulation of advanced glycation end products (AGEs) could be one of these mechanisms. We undertook this study to investigate the role of the receptor for AGEs (RAGE) in mediating the cellular...article 2006
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TNO Kwaliteit van Leven (author), Guimarães, A.H.C. (author), Barrett-Bergshoeff, M.M. (author), Criscuoli, M. (author), Evangelista, S. (author), Rijken, D.C. (author)In this study, the in-vitro fibrinolytic efficacy of Tenecteplase, Amediplase and scu-PA was investigated in different external lysis models by measuring the lysis of human plasma clots after the addition of the plasminogen activators (PAs) to the surrounding plasma. The effect of TAFI was examined for each PA by neutralising TAFIa with potato...article 2006
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TNO Preventie en Gezondheid (author), Buitendijk, S. (author), Zeitlin, J. (author), Cuttini, M. (author), Langhoff-Roos, J. (author), Bottu, J. (author)Objective: To assess the ability of the member states of the European Union to produce the indicators recommended by the PERISTAT project on perinatal health indicators and to provide an overview of fetal and infant health outcomes for these countries according to the information now available. Methods: We used data from the PERISTAT survey of...article 2003
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TNO Preventie en Gezondheid (author), Schuller, A.A. (author), Kalsbeek, H. (author)The purpose of this study was to study the effect of professionally applied topical fluoride on oral health status at the population level in adolescents with low socio-economic status. Adolescents attending dental clinics where professional fluoride application was a routine procedure (high-fluoride group) were compared to adolescents from...article 2003
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TNO Kwaliteit van Leven (author), Laurens, N. (author), Koolwijk, P. (author), de Maat, M.P. (author)Fibrinogen and fibrin play an important role in blood clotting, fibrinolysis, cellular and matrix interactions, inflammation, wound healing, angiogenesis, and neoplasia. The contribution of fibrin(ogen) to these processes largely depends not only on the characteristics of the fibrin(ogen) itself, but also on interactions between specific-binding...article 2006
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Terluin, B. (author), Terwee, C.B. (author), Eekhout, I. (author)Minimal clinically important difference (MCID) estimates are often used to interpret change scores from measurement instruments. Researchers debate how MCID values should be estimated. In a recent paper, Tenan et al1 recommended adjusting for baseline severity in the analysis to avoid biased MCID estimates due to regression to the mean (RTM)....article 2022